CRCGN014_HEPG2_3H:J13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclosporin-a 19.96 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

87 genes differentially expressed following the CRCGN014_HEPG2_3H:J13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 10.0
CIAO3 cytosolic iron-sulfur assembly component 3 6.3173
CYCS cytochrome c, somatic 5.29647
LPAR2 lysophosphatidic acid receptor 2 3.92116
LCN2 lipocalin 2 3.78145
HYOU1 hypoxia up-regulated 1 3.65624
CXCL2 chemokine (C-X-C motif) ligand 2 3.28628
CCNF cyclin F 3.2545
RPL39L ribosomal protein L39-like 3.20357
SATB1 SATB homeobox 1 3.02603
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.97346
TRIB3 tribbles pseudokinase 3 2.95733
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.90044
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.79255
HOOK2 hook microtubule-tethering protein 2 2.79162
PLSCR3 phospholipid scramblase 3 2.72124
PRKCQ protein kinase C, theta 2.61485
ZNF430 zinc finger protein 430 2.55917
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.55786
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.52339
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.51356
NOSIP nitric oxide synthase interacting protein 2.50538
GOLT1B golgi transport 1B 2.50016
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 2.49687
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.48807
CCDC90B coiled-coil domain containing 90B 2.48412
PLIN3 perilipin 3 2.47527
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.45111
SCRN1 secernin 1 2.43703
GSTZ1 glutathione S-transferase zeta 1 2.42873
SLC35B1 solute carrier family 35, member B1 2.4018
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.37396
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.34527
TIAM1 T-cell lymphoma invasion and metastasis 1 2.31925
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.31701
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.24751
OSMR oncostatin M receptor 2.22244
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.21401
LOC128125814 uncharacterized LOC128125814 2.17575
ZNF446 zinc finger protein 446 2.14124
AARS1 alanyl-tRNA synthetase 1 2.13044
IGHMBP2 immunoglobulin mu binding protein 2 2.12269
BCAT1 branched chain amino-acid transaminase 1, cytosolic 2.10185
UFM1 ubiquitin-fold modifier 1 2.09629
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.0952
CLBA1 clathrin binding box of aftiphilin containing 1 2.09342
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 2.09023
EGR1 early growth response 1 2.0653
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.05263
TAOK1 TAO kinase 1 2.03238
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like 2.01797
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.01382

decreased expression

Symbol Name Standardized Value
FASTKD5 FAST kinase domains 5 -7.7829
SPAG4 sperm associated antigen 4 -6.48121
MAPK13 mitogen-activated protein kinase 13 -5.22285
CDC20 cell division cycle 20 -4.65409
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -3.50735
CCNB1 cyclin B1 -3.28978
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.17367
GDF15 growth differentiation factor 15 -2.97174
SNX6 sorting nexin 6 -2.94257
FGFR4 fibroblast growth factor receptor 4 -2.87963
TLCD3A TLC domain containing 3A -2.85585
DSG2 desmoglein 2 -2.77015
OXA1L oxidase (cytochrome c) assembly 1-like -2.75994
KDM3A lysine (K)-specific demethylase 3A -2.73858
TLR4 toll-like receptor 4 -2.63432
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.62327
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.44418
LDHD lactate dehydrogenase D -2.42751
GNAS GNAS complex locus -2.3005
RGS2 regulator of G-protein signaling 2 -2.29973
ELAC2 elaC ribonuclease Z 2 -2.27939
CCNH cyclin H -2.272
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.26724
IFT70A intraflagellar transport 70A -2.23846
GFI1B growth factor independent 1B transcription repressor -2.16854
ZBED1 zinc finger, BED-type containing 1 -2.14872
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 -2.11671
SSX1 synovial sarcoma, X breakpoint 1 -2.08282
SSX4B synovial sarcoma, X breakpoint 4B -2.07323
TRIM58 tripartite motif containing 58 -2.07141
GCHFR GTP cyclohydrolase I feedback regulator -2.06289
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) -2.03777
SSX2 synovial sarcoma, X breakpoint 2 -2.03128
ESRP2 epithelial splicing regulatory protein 2 -2.02008
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -2.01646