CRCGN014_HEPG2_3H:J15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethyl 2-{(3z)-6-(ethylamino)-3-[(z)-ethylimino]-2,7-dimethyl-3h-xanthen-9-yl}benzoate hydrochloride 20.46 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

107 genes differentially expressed following the CRCGN014_HEPG2_3H:J15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HSPA1A heat shock 70kDa protein 1A 10.0
EGR1 early growth response 1 6.67415
DDIT4 DNA-damage-inducible transcript 4 6.41218
BAG3 BCL2-associated athanogene 3 6.40842
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.30854
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 6.05686
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 5.77932
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 5.64887
GADD45B growth arrest and DNA-damage-inducible, beta 5.43528
JUN jun proto-oncogene 5.15264
HSPA1B heat shock 70kDa protein 1B 5.08419
MAP7 microtubule-associated protein 7 4.58756
HSPB1 heat shock 27kDa protein 1 4.24537
PRR15L proline rich 15-like 3.93881
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.85733
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 3.79381
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.79291
JMJD6 jumonji domain containing 6 3.75743
JADE2 jade family PHD finger 2 3.73106
PNKP polynucleotide kinase 3'-phosphatase 3.72084
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.64083
GSTZ1 glutathione S-transferase zeta 1 3.5395
MAMLD1 mastermind-like domain containing 1 3.37385
ZFP36 ZFP36 ring finger protein 3.37171
IRX5 iroquois homeobox 5 3.04797
FRS2 fibroblast growth factor receptor substrate 2 2.99165
ATF3 activating transcription factor 3 2.93389
FOXO3 forkhead box O3 2.84984
CSK c-src tyrosine kinase 2.64745
TXNL4B thioredoxin-like 4B 2.64618
CYCS cytochrome c, somatic 2.56921
GADD45A growth arrest and DNA-damage-inducible, alpha 2.53954
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.45388
CFLAR CASP8 and FADD-like apoptosis regulator 2.42755
TUBB6 tubulin, beta 6 class V 2.41568
SORBS3 sorbin and SH3 domain containing 3 2.41566
HOXA5 homeobox A5 2.41529
EGF epidermal growth factor 2.40995
IER2 immediate early response 2 2.40857
HSPA6 heat shock 70kDa protein 6 (HSP70B') 2.40662
SOX4 SRY (sex determining region Y)-box 4 2.39962
FOXO4 forkhead box O4 2.39454
DUSP2 dual specificity phosphatase 2 2.3941
DUSP8 dual specificity phosphatase 8 2.39288
FOSL1 FOS-like antigen 1 2.38158
IER5 immediate early response 5 2.36103
TESK1 testis-specific kinase 1 2.34433
BTG2 BTG family, member 2 2.33602
PIH1D1 PIH1 domain containing 1 2.31941
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.30785
RHOB ras homolog family member B 2.29217
PTCD2 pentatricopeptide repeat domain 2 2.27825
EGR3 early growth response 3 2.21474
INPP1 inositol polyphosphate-1-phosphatase 2.19529
BAMBI BMP and activin membrane-bound inhibitor 2.16018
ZBTB10 zinc finger and BTB domain containing 10 2.1441
RGS2 regulator of G-protein signaling 2 2.13623
MEF2C myocyte enhancer factor 2C 2.12937
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 2.09781
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.09625
TICAM1 toll-like receptor adaptor molecule 1 2.05239
SKIC8 SKI8 subunit of superkiller complex 2.04264
PPY pancreatic polypeptide 2.034
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 2.02645
VGLL4 vestigial-like family member 4 2.02418

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.90839
PCNA proliferating cell nuclear antigen -6.58562
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.72884
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.94056
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.426
TRIB3 tribbles pseudokinase 3 -3.7891
GET1 guided entry of tail-anchored proteins factor 1 -3.70835
LDHD lactate dehydrogenase D -3.66601
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.66277
COG7 component of oligomeric golgi complex 7 -3.65088
C2CD5 C2 calcium-dependent domain containing 5 -3.56509
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.4223
CD58 CD58 molecule -3.41164
TXNRD1 thioredoxin reductase 1 -3.24145
CDC20 cell division cycle 20 -3.19439
TLR4 toll-like receptor 4 -3.18655
CCNB2 cyclin B2 -3.1001
ZMIZ1 zinc finger, MIZ-type containing 1 -2.95185
DCK deoxycytidine kinase -2.72683
SLC35F2 solute carrier family 35, member F2 -2.68921
EXT1 exostosin glycosyltransferase 1 -2.65193
HEATR1 HEAT repeat containing 1 -2.62747
RAP1GAP RAP1 GTPase activating protein -2.61816
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -2.51527
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.49328
ETFB electron-transfer-flavoprotein, beta polypeptide -2.48573
GNAS GNAS complex locus -2.37144
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.37005
KLHDC2 kelch domain containing 2 -2.29445
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon -2.28922
OXA1L oxidase (cytochrome c) assembly 1-like -2.28247
MAPK13 mitogen-activated protein kinase 13 -2.25164
TES testin LIM domain protein -2.24951
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.17294
LOC124907782 dual specificity protein phosphatase 22 -2.1714
CTNNBIP1 catenin, beta interacting protein 1 -2.16491
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 -2.14223
DSG2 desmoglein 2 -2.08544
GOLT1B golgi transport 1B -2.02607
MSH6 mutS homolog 6 -2.02123
KIF15 kinesin family member 15 -2.00403
SNX11 sorting nexin 11 -2.0002