CRCGN014_HEPG2_3H:J16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description CH-223191 21.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

158 genes differentially expressed following the CRCGN014_HEPG2_3H:J16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 7.46286
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 7.44372
CARMIL1 capping protein regulator and myosin 1 linker 1 5.06096
EVL Enah/Vasp-like 4.69134
AMDHD2 amidohydrolase domain containing 2 4.68
CSK c-src tyrosine kinase 4.42719
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.94543
CCP110 centriolar coiled coil protein 110kDa 3.89572
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 3.55528
SNAP25 synaptosomal-associated protein, 25kDa 3.36333
USP6NL USP6 N-terminal like 3.29929
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.16284
PPARG peroxisome proliferator-activated receptor gamma 3.13683
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.1297
HDGFL3 HDGF like 3 3.08765
DYNLT3 dynein, light chain, Tctex-type 3 3.05906
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.98502
ZBTB18 zinc finger and BTB domain containing 18 2.93292
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.84235
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.65222
ANO1 anoctamin 1, calcium activated chloride channel 2.60617
EPN2 epsin 2 2.58488
SSBP2 single-stranded DNA binding protein 2 2.51328
CEP57 centrosomal protein 57kDa 2.47843
FHL2 four and a half LIM domains 2 2.46832
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.4386
SYNE2 spectrin repeat containing, nuclear envelope 2 2.41872
PDE1A phosphodiesterase 1A, calmodulin-dependent 2.40415
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2.36021
PCCB propionyl CoA carboxylase, beta polypeptide 2.35687
PRDX1 peroxiredoxin 1 2.33706
FAM50A family with sequence similarity 50, member A 2.31294
RAMP1 receptor (G protein-coupled) activity modifying protein 1 2.30311
HDAC5 histone deacetylase 5 2.28726
PCNT pericentrin 2.24142
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.22977
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 2.22765
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 2.21423
RHCG Rh family, C glycoprotein 2.21397
TYK2 tyrosine kinase 2 2.20297
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.18828
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 2.18657
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma 2.18284
LY6D lymphocyte antigen 6 complex, locus D 2.17624
GTPBP6 GTP binding protein 6 (putative) 2.14096
CNPY3 canopy FGF signaling regulator 3 2.11877
TEX10 testis expressed 10 2.10316
XPA xeroderma pigmentosum, complementation group A 2.10298
KDM5A lysine (K)-specific demethylase 5A 2.09992
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.09299
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.09114
TACC2 transforming, acidic coiled-coil containing protein 2 2.08382
PFKL phosphofructokinase, liver 2.06876
LOC124907090 ankyrin repeat domain-containing protein SOWAHC-like 2.06806
GPER1 G protein-coupled estrogen receptor 1 2.06031
CHMP4B charged multivesicular body protein 4B 2.05909
BAG3 BCL2-associated athanogene 3 2.02595

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -6.45186
CCNB2 cyclin B2 -6.20783
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.05631
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.48977
TCEAL4 transcription elongation factor A (SII)-like 4 -3.90223
VAT1 vesicle amine transport 1 -3.88173
SLC35F2 solute carrier family 35, member F2 -3.7838
COG7 component of oligomeric golgi complex 7 -3.57942
DNM1L dynamin 1-like -3.39663
PCNA proliferating cell nuclear antigen -3.10563
ZNF586 zinc finger protein 586 -3.10163
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.06243
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.03334
NT5DC2 5'-nucleotidase domain containing 2 -3.00499
AHDC1 AT hook, DNA binding motif, containing 1 -3.00328
EDN1 endothelin 1 -2.99258
PRTN3 proteinase 3 -2.91535
DEFA4 defensin, alpha 4, corticostatin -2.84541
RAI14 retinoic acid induced 14 -2.83915
DENND2D DENN/MADD domain containing 2D -2.74161
DEFA3 defensin, alpha 3, neutrophil-specific -2.72152
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -2.71852
CA7 carbonic anhydrase VII -2.68717
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.67123
MAPK13 mitogen-activated protein kinase 13 -2.63347
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 -2.63154
KCTD13 potassium channel tetramerization domain containing 13 -2.60595
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -2.56982
IFNAR1 interferon (alpha, beta and omega) receptor 1 -2.54766
NOTCH1 notch 1 -2.51876
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 -2.48396
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) -2.47361
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.46847
OXA1L oxidase (cytochrome c) assembly 1-like -2.46113
GJA1 gap junction protein, alpha 1, 43kDa -2.45298
BPI bactericidal/permeability-increasing protein -2.45218
ELANE elastase, neutrophil expressed -2.42764
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 -2.41913
SLFN12 schlafen family member 12 -2.39986
HMG20B high mobility group 20B -2.39231
PSG5 pregnancy specific beta-1-glycoprotein 5 -2.39174
JHY junctional cadherin complex regulator -2.38934
SDC3 syndecan 3 -2.38143
FKBP4 FK506 binding protein 4, 59kDa -2.37619
THSD4 thrombospondin, type I, domain containing 4 -2.33854
CACTIN cactin, spliceosome C complex subunit -2.32204
DAAM2 dishevelled associated activator of morphogenesis 2 -2.32109
LRRC15 leucine rich repeat containing 15 -2.29436
SPMAP2 sperm microtubule associated protein 2 -2.29406
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 -2.27473
GALP galanin-like peptide -2.27216
PTPRK protein tyrosine phosphatase, receptor type, K -2.27114
PSRC1 proline/serine-rich coiled-coil 1 -2.26867
ACLY ATP citrate lyase -2.24665
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.24119
CYBRD1 cytochrome b reductase 1 -2.21769
AZU1 azurocidin 1 -2.21141
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.20298
FAIM Fas apoptotic inhibitory molecule -2.19824
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.18956
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 -2.1769
ONECUT2 one cut homeobox 2 -2.17484
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.16771
ANTXR1 anthrax toxin receptor 1 -2.14945
ZBTB7C zinc finger and BTB domain containing 7C -2.14714
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 -2.14539
LRIT1 leucine-rich repeat, immunoglobulin-like and transmembrane domains 1 -2.14127
TLX3 T-cell leukemia homeobox 3 -2.13787
ODF1 outer dense fiber of sperm tails 1 -2.13545
PRKCE protein kinase C, epsilon -2.13242
TRIM46 tripartite motif containing 46 -2.13174
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -2.12664
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.12625
GATA1 GATA binding protein 1 (globin transcription factor 1) -2.11933
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 -2.11446
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.11427
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 -2.10248
CAV1 caveolin 1, caveolae protein, 22kDa -2.10163
ZNF208 zinc finger protein 208 -2.09727
TFDP3 transcription factor Dp family, member 3 -2.09374
PEG10 paternally expressed 10 -2.08751
GJA5 gap junction protein, alpha 5, 40kDa -2.08017
FOXF2 forkhead box F2 -2.07446
ADGRG3 adhesion G protein-coupled receptor G3 -2.07082
CNTRL centriolin -2.06573
TLR3 toll-like receptor 3 -2.06417
DAGLA diacylglycerol lipase, alpha -2.05725
CD320 CD320 molecule -2.05148
PLA2G2F phospholipase A2, group IIF -2.04938
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 -2.04752
RTL8A retrotransposon Gag like 8A -2.04327
PSG6 pregnancy specific beta-1-glycoprotein 6 -2.04206
FZD1 frizzled class receptor 1 -2.03814
CTSD cathepsin D -2.03711
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -2.03622
HSPA4 heat shock 70kDa protein 4 -2.03568
MMP13 matrix metallopeptidase 13 -2.02804
DNAAF8 dynein axonemal assembly factor 8 -2.02064
CD69 CD69 molecule -2.01993
CXCL9 chemokine (C-X-C motif) ligand 9 -2.01251
CAMK1G calcium/calmodulin-dependent protein kinase IG -2.00967