CRCGN014_HEPG2_3H:J17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxymetholone 40.4 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

103 genes differentially expressed following the CRCGN014_HEPG2_3H:J17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HSPA1A heat shock 70kDa protein 1A 10.0
DDIT4 DNA-damage-inducible transcript 4 9.85498
HMOX1 heme oxygenase 1 8.11374
CYCS cytochrome c, somatic 7.24188
ABHD4 abhydrolase domain containing 4 6.10696
BAG3 BCL2-associated athanogene 3 5.07278
HSPA1B heat shock 70kDa protein 1B 4.2272
TATDN2 TatD DNase domain containing 2 4.05935
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 3.73325
ADRB2 adrenoceptor beta 2, surface 3.69465
STIMATE STIM activating enhancer 3.65362
CHMP6 charged multivesicular body protein 6 3.36113
TXNRD1 thioredoxin reductase 1 3.32198
GPATCH8 G patch domain containing 8 3.30665
GPER1 G protein-coupled estrogen receptor 1 3.28625
LCN2 lipocalin 2 3.28064
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.25876
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.25142
LAGE3 L antigen family, member 3 3.22976
STAP2 signal transducing adaptor family member 2 3.22122
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.11934
EAPP E2F-associated phosphoprotein 3.11862
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.06036
GCC1 GRIP and coiled-coil domain containing 1 2.97741
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.95985
E2F2 E2F transcription factor 2 2.85341
SNAP25 synaptosomal-associated protein, 25kDa 2.80773
HOXA10 homeobox A10 2.75802
CGRRF1 cell growth regulator with ring finger domain 1 2.75764
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.73569
AARS1 alanyl-tRNA synthetase 1 2.64341
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.57821
GOLGA4 golgin A4 2.57371
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.55358
LOC128125814 uncharacterized LOC128125814 2.53387
BLMH bleomycin hydrolase 2.48291
RFC2 replication factor C (activator 1) 2, 40kDa 2.43805
KEAP1 kelch-like ECH-associated protein 1 2.41585
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.39548
TRIB3 tribbles pseudokinase 3 2.3412
PHF21A PHD finger protein 21A 2.33809
FKBP14 FK506 binding protein 14, 22 kDa 2.30172
TOGARAM1 TOG array regulator of axonemal microtubules 1 2.2981
HYOU1 hypoxia up-regulated 1 2.28194
SQSTM1 sequestosome 1 2.28154
ELOVL6 ELOVL fatty acid elongase 6 2.2434
COL4A1 collagen, type IV, alpha 1 2.24299
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 2.19309
CEP57 centrosomal protein 57kDa 2.15906
HSPA6 heat shock 70kDa protein 6 (HSP70B') 2.15051
RPP38 ribonuclease P/MRP 38kDa subunit 2.14694
EMC3 ER membrane protein complex subunit 3 2.1241
STYXL1 serine/threonine/tyrosine interacting-like 1 2.12239
MNS1 meiosis-specific nuclear structural 1 2.10109
DIPK1A divergent protein kinase domain 1A 2.09303
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.06616
LOC122526780 uncharacterized LOC122526780 2.05227
BIRC2 baculoviral IAP repeat containing 2 2.04497
MCUR1 mitochondrial calcium uniporter regulator 1 2.04468
GOLT1A golgi transport 1A 2.04415
CCP110 centriolar coiled coil protein 110kDa 2.04324
DEF8 differentially expressed in FDCP 8 homolog (mouse) 2.04284
DDB2 damage-specific DNA binding protein 2, 48kDa 2.04171
CCDC92 coiled-coil domain containing 92 2.03898
ENDOG endonuclease G 2.03825
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 2.03171
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.02874
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 2.01259
IRAK4 interleukin-1 receptor-associated kinase 4 2.00306
DBF4B DBF4 zinc finger B 2.00054

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.83558
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -6.6567
CCNB2 cyclin B2 -6.06939
IER3 immediate early response 3 -5.73274
DUSP6 dual specificity phosphatase 6 -5.16036
ELAC2 elaC ribonuclease Z 2 -4.4174
GRWD1 glutamate-rich WD repeat containing 1 -4.23933
INPP1 inositol polyphosphate-1-phosphatase -3.94012
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -3.653
FGFR4 fibroblast growth factor receptor 4 -3.65272
PCNA proliferating cell nuclear antigen -3.54224
C2CD5 C2 calcium-dependent domain containing 5 -3.52406
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.10237
TLR4 toll-like receptor 4 -3.08911
TLCD3A TLC domain containing 3A -3.07526
EDN1 endothelin 1 -2.76904
SNX11 sorting nexin 11 -2.67946
GNAS GNAS complex locus -2.6271
CYBRD1 cytochrome b reductase 1 -2.58527
CCDC86 coiled-coil domain containing 86 -2.45338
ISOC1 isochorismatase domain containing 1 -2.32005
POLR2H polymerase (RNA) II (DNA directed) polypeptide H -2.31916
TUBB6 tubulin, beta 6 class V -2.29503
TRIB1 tribbles pseudokinase 1 -2.23772
RPIA ribose 5-phosphate isomerase A -2.18665
GRK3 G protein-coupled receptor kinase 3 -2.14801
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -2.12148
NISCH nischarin -2.05016
CTNND1 catenin (cadherin-associated protein), delta 1 -2.04246
SDC2 syndecan 2 -2.02891
OXA1L oxidase (cytochrome c) assembly 1-like -2.02648
SDAD1 SDA1 domain containing 1 -2.02611
HEG1 heart development protein with EGF-like domains 1 -2.00466