CRCGN014_HEPG2_3H:J18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description kepone 21.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

322 genes differentially expressed following the CRCGN014_HEPG2_3H:J18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 10.0
HSPA1A heat shock 70kDa protein 1A 10.0
FOS FBJ murine osteosarcoma viral oncogene homolog 8.33615
EGR1 early growth response 1 8.01888
UBQLN2 ubiquilin 2 7.43271
CXCL2 chemokine (C-X-C motif) ligand 2 7.15397
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 7.07774
PPARG peroxisome proliferator-activated receptor gamma 6.63098
H2BC12 H2B clustered histone 12 6.16856
JUN jun proto-oncogene 6.13581
TERT telomerase reverse transcriptase 5.89906
BAG3 BCL2-associated athanogene 3 5.59836
ZFP36 ZFP36 ring finger protein 5.52165
DDIT4 DNA-damage-inducible transcript 4 5.42545
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.42032
SHB Src homology 2 domain containing adaptor protein B 5.37992
GADD45B growth arrest and DNA-damage-inducible, beta 4.56745
KIFBP kinesin family binding protein 4.53412
FOSL1 FOS-like antigen 1 4.45401
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.4476
HSPA1B heat shock 70kDa protein 1B 4.13818
ATF3 activating transcription factor 3 4.0013
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.99298
UBE2L6 ubiquitin-conjugating enzyme E2L 6 3.83974
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.79202
TRAPPC6A trafficking protein particle complex 6A 3.78914
TRIB1 tribbles pseudokinase 1 3.77402
FCHO1 FCH domain only 1 3.70744
GHR growth hormone receptor 3.64555
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.58927
IER2 immediate early response 2 3.50785
RAI14 retinoic acid induced 14 3.48144
IER3 immediate early response 3 3.48005
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.41259
EPHA3 EPH receptor A3 3.3897
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.36376
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.33798
NFIL3 nuclear factor, interleukin 3 regulated 3.27355
PPP1R15A protein phosphatase 1, regulatory subunit 15A 3.25106
CORO1A coronin, actin binding protein, 1A 3.19425
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.15753
HEBP1 heme binding protein 1 3.13241
PEX11A peroxisomal biogenesis factor 11 alpha 3.12024
IER5 immediate early response 5 3.08994
TRIM13 tripartite motif containing 13 3.07319
HTRA1 HtrA serine peptidase 1 3.0631
DUSP6 dual specificity phosphatase 6 3.01793
RTN2 reticulon 2 3.00462
SOCS2 suppressor of cytokine signaling 2 2.98571
ADGRG1 adhesion G protein-coupled receptor G1 2.96849
PTK2B protein tyrosine kinase 2 beta 2.96178
KLF6 Kruppel-like factor 6 2.9155
CLDN14 claudin 14 2.9106
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.89398
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.87151
HOXA10 homeobox A10 2.86893
IL1B interleukin 1, beta 2.86368
LOC102724023 ES1 protein homolog, mitochondrial 2.85991
CTSD cathepsin D 2.72042
PELI1 pellino E3 ubiquitin protein ligase 1 2.70744
ICAM1 intercellular adhesion molecule 1 2.7042
CIAO3 cytosolic iron-sulfur assembly component 3 2.69482
TESK1 testis-specific kinase 1 2.68579
PRR15L proline rich 15-like 2.68508
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 2.66152
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.64878
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.63549
IFNAR1 interferon (alpha, beta and omega) receptor 1 2.63548
INPP1 inositol polyphosphate-1-phosphatase 2.63121
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.62552
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.62539
CBR1 carbonyl reductase 1 2.61562
TSC22D3 TSC22 domain family, member 3 2.61169
PRKCD protein kinase C, delta 2.6004
BTG1 B-cell translocation gene 1, anti-proliferative 2.58965
LPL lipoprotein lipase 2.57452
PTMS parathymosin 2.56757
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 2.54731
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.52984
CHN1 chimerin 1 2.52835
LRIT1 leucine-rich repeat, immunoglobulin-like and transmembrane domains 1 2.52793
HSPA6 heat shock 70kDa protein 6 (HSP70B') 2.52101
LYN LYN proto-oncogene, Src family tyrosine kinase 2.51931
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.51694
H2BC3 H2B clustered histone 3 2.50465
BARX1 BARX homeobox 1 2.49989
PTK2 protein tyrosine kinase 2 2.48748
PNRC1 proline-rich nuclear receptor coactivator 1 2.48652
PTPRK protein tyrosine phosphatase, receptor type, K 2.47494
DENND1B DENN/MADD domain containing 1B 2.46042
MAMLD1 mastermind-like domain containing 1 2.45291
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.44866
GADD45A growth arrest and DNA-damage-inducible, alpha 2.44662
TBPL1 TBP-like 1 2.43147
DGKB diacylglycerol kinase, beta 90kDa 2.42907
NOTCH1 notch 1 2.39895
IPO13 importin 13 2.38229
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.35381
ERI3 ERI1 exoribonuclease family member 3 2.35362
C2CD2L C2CD2-like 2.35231
ARL4C ADP-ribosylation factor-like 4C 2.35204
BTBD2 BTB (POZ) domain containing 2 2.3429
ALAS1 5'-aminolevulinate synthase 1 2.33896
GDI1 GDP dissociation inhibitor 1 2.33641
KLF2 Kruppel-like factor 2 2.32248
TCEAL9 transcription elongation factor A like 9 2.31852
NVL nuclear VCP-like 2.31367
CCNA1 cyclin A1 2.3047
CYSLTR1 cysteinyl leukotriene receptor 1 2.29767
POU4F3 POU class 4 homeobox 3 2.28517
MYNN myoneurin 2.28366
THSD4 thrombospondin, type I, domain containing 4 2.27806
PTCD2 pentatricopeptide repeat domain 2 2.26927
GAS6 growth arrest-specific 6 2.25592
CAPN1 calpain 1, (mu/I) large subunit 2.25361
ZNF140 zinc finger protein 140 2.24488
DEPP1 DEPP autophagy regulator 1 2.23823
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.21829
GJD3 gap junction protein, delta 3, 31.9kDa 2.20497
BACE1 beta-site APP-cleaving enzyme 1 2.19838
GARRE1 granule associated Rac and RHOG effector 1 2.1969
CCKAR cholecystokinin A receptor 2.19577
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.18464
HOXD10 homeobox D10 2.18251
NNAT neuronatin 2.17933
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.16623
MEST mesoderm specific transcript 2.1648
MOCS1 molybdenum cofactor synthesis 1 2.16299
FBXO28 F-box protein 28 2.15991
CRABP2 cellular retinoic acid binding protein 2 2.1522
STK10 serine/threonine kinase 10 2.15011
KLHDC3 kelch domain containing 3 2.14686
JCAD junctional cadherin 5 associated 2.13919
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.13506
H2BC9 H2B clustered histone 9 2.13466
CNPY3 canopy FGF signaling regulator 3 2.13068
NR4A1 nuclear receptor subfamily 4, group A, member 1 2.1272
H2BC4 H2B clustered histone 4 2.12021
DUSP5 dual specificity phosphatase 5 2.1173
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 2.10645
BFSP1 beaded filament structural protein 1, filensin 2.09252
ATP11B ATPase, class VI, type 11B 2.08679
BPHL biphenyl hydrolase-like (serine hydrolase) 2.08468
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.07279
SCN8A sodium channel, voltage gated, type VIII alpha subunit 2.06811
PLSCR3 phospholipid scramblase 3 2.06571
EGR3 early growth response 3 2.05806
BAX BCL2-associated X protein 2.0534
H2BC14 H2B clustered histone 14 2.05328
ADIRF adipogenesis regulatory factor 2.03926
CEP15 centrosomal protein 15 2.03882
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.0354
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa 2.03446
IGFBP5 insulin-like growth factor binding protein 5 2.03289
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.03204
HPCAL1 hippocalcin-like 1 2.03007
BHLHE40 basic helix-loop-helix family, member e40 2.02971
FAM13A family with sequence similarity 13, member A 2.02911
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.02791
RTL8C retrotransposon Gag like 8C 2.02539
H1-4 H1.4 linker histone, cluster member 2.02296
ZNF804A zinc finger protein 804A 2.01931
TIMP2 TIMP metallopeptidase inhibitor 2 2.01805
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.01703
SDC1 syndecan 1 2.01558
HABP2 hyaluronan binding protein 2 2.00901
LPAR3 lysophosphatidic acid receptor 3 2.00491
INSIG1 insulin induced gene 1 2.00418
DUSP4 dual specificity phosphatase 4 2.00225
SREK1IP1 SREK1-interacting protein 1 2.00101
CRIP2 cysteine-rich protein 2 2.00005

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -7.13386
HAT1 histone acetyltransferase 1 -7.11693
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -7.07364
BLCAP bladder cancer associated protein -6.4813
ETFB electron-transfer-flavoprotein, beta polypeptide -5.91731
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -5.80947
B4GAT1 beta-1,4-glucuronyltransferase 1 -5.78213
UBE3C ubiquitin protein ligase E3C -5.56543
FASTKD5 FAST kinase domains 5 -5.23892
SLC35F2 solute carrier family 35, member F2 -5.06809
CDC20 cell division cycle 20 -4.98393
CCNB2 cyclin B2 -4.91045
TXNRD1 thioredoxin reductase 1 -4.88046
CD58 CD58 molecule -4.79019
PROS1 protein S (alpha) -4.38499
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.28146
GET1 guided entry of tail-anchored proteins factor 1 -4.15721
LDHD lactate dehydrogenase D -4.1117
CD320 CD320 molecule -4.0862
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.96537
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -3.85976
LBR lamin B receptor -3.74382
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -3.71737
KLHL21 kelch-like family member 21 -3.6739
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.62992
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.61814
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.60949
MACF1 microtubule-actin crosslinking factor 1 -3.56414
COG7 component of oligomeric golgi complex 7 -3.537
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.48284
ZNF586 zinc finger protein 586 -3.43234
TXLNA taxilin alpha -3.36384
OXA1L oxidase (cytochrome c) assembly 1-like -3.3626
IGF2R insulin-like growth factor 2 receptor -3.31807
MLEC malectin -3.29561
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.27922
TLCD3A TLC domain containing 3A -3.22699
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -3.21645
PGM1 phosphoglucomutase 1 -3.18598
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.17957
IQGAP2 IQ motif containing GTPase activating protein 2 -3.03664
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.03405
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -3.01289
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.00682
LGMN legumain -3.00268
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.99707
ACOT9 acyl-CoA thioesterase 9 -2.99064
SPAG4 sperm associated antigen 4 -2.98319
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta -2.97991
HEATR1 HEAT repeat containing 1 -2.97544
STMN1 stathmin 1 -2.95531
CTR9 CTR9, Paf1/RNA polymerase II complex component -2.95317
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -2.93699
MVP major vault protein -2.88374
CHPT1 choline phosphotransferase 1 -2.88209
GNAS GNAS complex locus -2.86219
DSG2 desmoglein 2 -2.83496
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.83084
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.78686
SKIC2 SKI2 subunit of superkiller complex -2.77585
USP6NL USP6 N-terminal like -2.77363
HDAC1 histone deacetylase 1 -2.76044
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.7477
UGDH UDP-glucose 6-dehydrogenase -2.73453
TM9SF3 transmembrane 9 superfamily member 3 -2.71879
CLTC clathrin, heavy chain (Hc) -2.70376
FBXO7 F-box protein 7 -2.67705
EED embryonic ectoderm development -2.67121
BCL7B B-cell CLL/lymphoma 7B -2.61841
PARP1 poly (ADP-ribose) polymerase 1 -2.60134
GAA glucosidase, alpha; acid -2.59939
PGAM4 phosphoglycerate mutase family member 4 -2.59319
CRYZ crystallin, zeta (quinone reductase) -2.5761
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.56699
HDAC2 histone deacetylase 2 -2.5499
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.53841
TRIB3 tribbles pseudokinase 3 -2.52671
NISCH nischarin -2.51217
CDK4 cyclin-dependent kinase 4 -2.50108
CRTAP cartilage associated protein -2.49619
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.45149
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -2.45135
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.44429
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.43429
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.42872
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -2.41712
GLOD4 glyoxalase domain containing 4 -2.41402
CCNB1 cyclin B1 -2.38747
TBC1D16 TBC1 domain family, member 16 -2.38015
KDM1A lysine (K)-specific demethylase 1A -2.37983
HMOX1 heme oxygenase 1 -2.37245
TOP2B topoisomerase (DNA) II beta 180kDa -2.35798
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.35243
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 -2.35136
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.33877
ZDHHC6 zinc finger, DHHC-type containing 6 -2.3188
PRCP prolylcarboxypeptidase (angiotensinase C) -2.3142
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.31216
PIGH phosphatidylinositol glycan anchor biosynthesis, class H -2.30835
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.30181
FAM168B family with sequence similarity 168, member B -2.3013
NAT10 N-acetyltransferase 10 (GCN5-related) -2.29724
MRPS7 mitochondrial ribosomal protein S7 -2.29408
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -2.28611
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.27988
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.26839
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.25175
GTF2A2 general transcription factor IIA, 2, 12kDa -2.2402
SLC35B1 solute carrier family 35, member B1 -2.23682
NAP1L4 nucleosome assembly protein 1-like 4 -2.21853
LARS2 leucyl-tRNA synthetase 2, mitochondrial -2.19896
CDC123 cell division cycle 123 -2.19505
PRDX1 peroxiredoxin 1 -2.18223
GALE UDP-galactose-4-epimerase -2.17869
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 -2.16611
TRAPPC4 trafficking protein particle complex 4 -2.15973
NOP56 NOP56 ribonucleoprotein -2.15795
ATP13A2 ATPase type 13A2 -2.15456
KCTD7 potassium channel tetramerization domain containing 7 -2.14837
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.14582
FUCA1 fucosidase, alpha-L- 1, tissue -2.14411
JARID2 jumonji, AT rich interactive domain 2 -2.14401
CYTH1 cytohesin 1 -2.12432
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.12321
TBX2 T-box 2 -2.11668
CSE1L CSE1 chromosome segregation 1-like (yeast) -2.11512
RBM14-RBM4 RBM14-RBM4 readthrough -2.11
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.1088
WASHC4 WASH complex subunit 4 -2.09977
PYCR1 pyrroline-5-carboxylate reductase 1 -2.09497
ADO 2-aminoethanethiol (cysteamine) dioxygenase -2.08963
MYLK myosin light chain kinase -2.08562
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -2.08098
ATG9A autophagy related 9A -2.0793
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -2.07882
MPZL1 myelin protein zero-like 1 -2.07847
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 -2.07176
MARCKSL1 MARCKS-like 1 -2.07013
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.06186
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.05577
PLIN3 perilipin 3 -2.05028
STARD3 StAR-related lipid transfer (START) domain containing 3 -2.04826
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.04765
TCTA T-cell leukemia translocation altered -2.04082
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.04058
NCK2 NCK adaptor protein 2 -2.03749
GRWD1 glutamate-rich WD repeat containing 1 -2.03556
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) -2.02453
NLRP2B NLR family pyrin domain containing 2B -2.01852
NASP nuclear autoantigenic sperm protein (histone-binding) -2.00953
WDR37 WD repeat domain 37 -2.00872