CRCGN014_HEPG2_3H:J19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description norethindrone 20.56 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

106 genes differentially expressed following the CRCGN014_HEPG2_3H:J19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 5.54479
CBR3 carbonyl reductase 3 5.36767
MYLK myosin light chain kinase 4.43936
KIFBP kinesin family binding protein 4.24289
MYC v-myc avian myelocytomatosis viral oncogene homolog 4.10421
EGR1 early growth response 1 4.00812
CHN1 chimerin 1 3.93623
IGFBP3 insulin-like growth factor binding protein 3 3.61719
ZNF589 zinc finger protein 589 3.46449
CCL2 chemokine (C-C motif) ligand 2 3.3279
JADE2 jade family PHD finger 2 3.20677
PRKCD protein kinase C, delta 3.17165
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.11355
CRTAP cartilage associated protein 3.05085
PPARG peroxisome proliferator-activated receptor gamma 2.99319
LOC128125814 uncharacterized LOC128125814 2.92564
HOXA10 homeobox A10 2.89114
TEX10 testis expressed 10 2.83495
TIMP2 TIMP metallopeptidase inhibitor 2 2.74291
CHMP6 charged multivesicular body protein 6 2.71981
ZBTB18 zinc finger and BTB domain containing 18 2.69263
CIAO3 cytosolic iron-sulfur assembly component 3 2.66339
AARS1 alanyl-tRNA synthetase 1 2.66337
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.64664
IER3 immediate early response 3 2.64462
TRIB3 tribbles pseudokinase 3 2.6387
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.59638
CCP110 centriolar coiled coil protein 110kDa 2.57088
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.56442
RPL39L ribosomal protein L39-like 2.50141
FCHO1 FCH domain only 1 2.46832
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.46534
MBD5 methyl-CpG binding domain protein 5 2.43682
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.42231
CYCS cytochrome c, somatic 2.34474
NOSIP nitric oxide synthase interacting protein 2.33197
HDGFL3 HDGF like 3 2.33156
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.3195
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.30355
GSAP gamma-secretase activating protein 2.29563
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.29129
SCRN1 secernin 1 2.28892
BACE2 beta-site APP-cleaving enzyme 2 2.28649
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.28124
C2CD2 C2 calcium-dependent domain containing 2 2.28097
XPOT exportin, tRNA 2.28016
ZFP36 ZFP36 ring finger protein 2.23163
KLHL21 kelch-like family member 21 2.22236
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.22179
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.2063
CEPT1 choline/ethanolamine phosphotransferase 1 2.1728
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.15318
CNIH3 cornichon family AMPA receptor auxiliary protein 3 2.13162
KDM5D lysine (K)-specific demethylase 5D 2.08301
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.07618
TERF2IP telomeric repeat binding factor 2, interacting protein 2.05642
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.04759
RFC2 replication factor C (activator 1) 2, 40kDa 2.02636
MAST2 microtubule associated serine/threonine kinase 2 2.01233

decreased expression

Symbol Name Standardized Value
FASTKD5 FAST kinase domains 5 -8.21679
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -7.88361
LDHD lactate dehydrogenase D -7.10455
LOC124907782 dual specificity protein phosphatase 22 -5.99453
NGRN neugrin, neurite outgrowth associated -4.85049
TLR4 toll-like receptor 4 -4.21481
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.18239
LAP3 leucine aminopeptidase 3 -4.14321
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.94706
ISOC1 isochorismatase domain containing 1 -3.64075
CD320 CD320 molecule -3.53855
CCNB2 cyclin B2 -3.51878
KHDC4 KH domain containing 4, pre-mRNA splicing factor -3.1368
VAT1 vesicle amine transport 1 -3.05742
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.86188
PSRC1 proline/serine-rich coiled-coil 1 -2.84008
PCNA proliferating cell nuclear antigen -2.83907
DERA deoxyribose-phosphate aldolase (putative) -2.81896
OXA1L oxidase (cytochrome c) assembly 1-like -2.77104
SNX11 sorting nexin 11 -2.70809
SLC35F2 solute carrier family 35, member F2 -2.62758
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.51625
TLR1 toll-like receptor 1 -2.45147
ANKEF1 ankyrin repeat and EF-hand domain containing 1 -2.37519
SLC25A44 solute carrier family 25, member 44 -2.32352
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -2.24283
MARCHF2 membrane associated ring-CH-type finger 2 -2.24227
MSH6 mutS homolog 6 -2.23556
ATG4A autophagy related 4A, cysteine peptidase -2.23466
MRFAP1L1 Morf4 family associated protein 1-like 1 -2.22257
BPHL biphenyl hydrolase-like (serine hydrolase) -2.21935
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.20686
TCTN1 tectonic family member 1 -2.17733
SUCO SUN domain containing ossification factor -2.14343
ADAR adenosine deaminase, RNA-specific -2.12854
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) -2.12687
SYNPO synaptopodin -2.12358
RGS2 regulator of G-protein signaling 2 -2.11166
ANKRD10 ankyrin repeat domain 10 -2.10975
DOCK4 dedicator of cytokinesis 4 -2.1032
BLCAP bladder cancer associated protein -2.09108
MARCHF8 membrane associated ring-CH-type finger 8 -2.08299
XK X-linked Kx blood group -2.0804
PRDM4 PR domain containing 4 -2.04288
UCN urocortin -2.04065
CST5 cystatin D -2.02579
IL18 interleukin 18 -2.00266