| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | alpha-methyldopa sesquihydrate 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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54 genes differentially expressed following the CRCGN014_HEPG2_3H:J20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 5.21137 |
| ADRB2 | adrenoceptor beta 2, surface | 4.96592 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 4.72576 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 4.64566 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.48286 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 3.67841 |
| HOXA10 | homeobox A10 | 3.66549 |
| VGLL4 | vestigial-like family member 4 | 3.39253 |
| COPS7A | COP9 signalosome subunit 7A | 3.33105 |
| MYLK | myosin light chain kinase | 2.70517 |
| MX2 | MX dynamin-like GTPase 2 | 2.64825 |
| ALDOC | aldolase C, fructose-bisphosphate | 2.6131 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 2.60384 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.53517 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 2.49297 |
| CHN1 | chimerin 1 | 2.47662 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.3357 |
| STXBP2 | syntaxin binding protein 2 | 2.32871 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 2.32035 |
| UBQLN2 | ubiquilin 2 | 2.30196 |
| RNF144A | ring finger protein 144A | 2.24681 |
| FRAT1 | frequently rearranged in advanced T-cell lymphomas 1 | 2.19126 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.1499 |
| MXRA5 | matrix-remodelling associated 5 | 2.11291 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 2.08511 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 2.06145 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.03857 |
| MAGEA12 | melanoma antigen family A12 | 2.01467 |
| Symbol | Name | Standardized Value |
|---|---|---|
| OXA1L | oxidase (cytochrome c) assembly 1-like | -5.23615 |
| SMNDC1 | survival motor neuron domain containing 1 | -5.02435 |
| FASTKD5 | FAST kinase domains 5 | -4.9792 |
| LDHD | lactate dehydrogenase D | -4.88534 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.70493 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -4.70479 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -4.42518 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -3.17785 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -2.96592 |
| REEP5 | receptor accessory protein 5 | -2.89997 |
| WASHC4 | WASH complex subunit 4 | -2.7613 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -2.58182 |
| VAT1 | vesicle amine transport 1 | -2.58115 |
| TRIB3 | tribbles pseudokinase 3 | -2.5448 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -2.50721 |
| MRPS2 | mitochondrial ribosomal protein S2 | -2.46506 |
| TXNDC9 | thioredoxin domain containing 9 | -2.40507 |
| MAD2L1BP | MAD2L1 binding protein | -2.36925 |
| SARAF | store-operated calcium entry-associated regulatory factor | -2.22425 |
| PLK1 | polo-like kinase 1 | -2.22053 |
| GTF2H1 | general transcription factor IIH, polypeptide 1, 62kDa | -2.11166 |
| HJURP | Holliday junction recognition protein | -2.10085 |
| GIN1 | gypsy retrotransposon integrase 1 | -2.0505 |
| PCNA | proliferating cell nuclear antigen | -2.03288 |
| SYF2 | SYF2 pre-mRNA-splicing factor | -2.02935 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | -2.00727 |
