CRCGN014_HEPG2_3H:J24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description potassium 1h-indol-3-yl sulfate 21.71 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

55 genes differentially expressed following the CRCGN014_HEPG2_3H:J24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 6.92053
CIAO3 cytosolic iron-sulfur assembly component 3 6.22294
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.20714
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.62736
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.80086
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.3909
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.33214
RAP1GAP RAP1 GTPase activating protein 3.32251
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.05323
MAMLD1 mastermind-like domain containing 1 2.95713
PPARG peroxisome proliferator-activated receptor gamma 2.88621
CCDC86 coiled-coil domain containing 86 2.84572
CXCL2 chemokine (C-X-C motif) ligand 2 2.73116
TXNRD1 thioredoxin reductase 1 2.7133
AMDHD2 amidohydrolase domain containing 2 2.58031
CDC25B cell division cycle 25B 2.56685
INPP1 inositol polyphosphate-1-phosphatase 2.54243
UBQLN2 ubiquilin 2 2.5225
SAA2 serum amyloid A2 2.50353
MAP7 microtubule-associated protein 7 2.49936
E2F2 E2F transcription factor 2 2.44752
ABHD6 abhydrolase domain containing 6 2.44059
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.40718
PTK2 protein tyrosine kinase 2 2.37305
CYTH1 cytohesin 1 2.33446
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 2.32368
HPS4 Hermansky-Pudlak syndrome 4 2.15742
CYCS cytochrome c, somatic 2.13493
HEXB hexosaminidase B (beta polypeptide) 2.06777
POLR1D polymerase (RNA) I polypeptide D, 16kDa 2.01325
UGDH UDP-glucose 6-dehydrogenase 2.01324
LOC122526780 uncharacterized LOC122526780 2.00247
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.00173

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
CCNB2 cyclin B2 -6.92819
ZNF586 zinc finger protein 586 -5.96311
ARID5B AT rich interactive domain 5B (MRF1-like) -4.79926
OXA1L oxidase (cytochrome c) assembly 1-like -4.52319
TRIB3 tribbles pseudokinase 3 -3.90242
NT5DC2 5'-nucleotidase domain containing 2 -3.80707
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.39115
BPHL biphenyl hydrolase-like (serine hydrolase) -3.16976
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.06245
GNAS GNAS complex locus -2.98275
TLR4 toll-like receptor 4 -2.6842
YME1L1 YME1-like 1 ATPase -2.3402
VAT1 vesicle amine transport 1 -2.22694
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -2.18493
RAI14 retinoic acid induced 14 -2.14218
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.08128
RPL3L ribosomal protein L3-like -2.07685
COL17A1 collagen, type XVII, alpha 1 -2.07551
DENND2A DENN/MADD domain containing 2A -2.07349
HLA-DMA major histocompatibility complex, class II, DM alpha -2.05446
TDP1 tyrosyl-DNA phosphodiesterase 1 -2.042