CRCGN014_HEPG2_3H:K02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-amino-3-oxo-3h-phenoxazine-1,9-dicarboxylic acid 19.98 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

217 genes differentially expressed following the CRCGN014_HEPG2_3H:K02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 7.13482
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 7.09978
ABHD4 abhydrolase domain containing 4 6.49178
RPL39L ribosomal protein L39-like 5.60882
UBQLN2 ubiquilin 2 5.55104
ANO1 anoctamin 1, calcium activated chloride channel 5.46925
HMOX1 heme oxygenase 1 4.99741
TXNRD1 thioredoxin reductase 1 4.9584
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 4.95285
STK10 serine/threonine kinase 10 4.86364
E2F2 E2F transcription factor 2 4.79553
CDPF1 cysteine-rich, DPF motif domain containing 1 4.47125
FOSL1 FOS-like antigen 1 4.41112
MAP7 microtubule-associated protein 7 4.11898
HSPA1A heat shock 70kDa protein 1A 3.91361
NANOS3 nanos homolog 3 (Drosophila) 3.87763
RALGDS ral guanine nucleotide dissociation stimulator 3.80847
CCL2 chemokine (C-C motif) ligand 2 3.80716
BACE2 beta-site APP-cleaving enzyme 2 3.7513
GAA glucosidase, alpha; acid 3.70253
LCN2 lipocalin 2 3.69772
ADGRE5 adhesion G protein-coupled receptor E5 3.67162
CXCL2 chemokine (C-X-C motif) ligand 2 3.52496
SCYL3 SCY1-like 3 (S. cerevisiae) 3.38516
HOXA10 homeobox A10 3.3414
EGR1 early growth response 1 3.29459
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.22585
CD19 CD19 molecule 3.22415
TAC4 tachykinin 4 (hemokinin) 3.18112
MEF2C myocyte enhancer factor 2C 3.17822
AOC2 amine oxidase, copper containing 2 (retina-specific) 3.16488
PARP1 poly (ADP-ribose) polymerase 1 3.10399
DDIT4 DNA-damage-inducible transcript 4 3.09677
KLHL21 kelch-like family member 21 3.0577
IER3 immediate early response 3 3.05309
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.03244
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 3.01251
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.00168
C2CD2 C2 calcium-dependent domain containing 2 2.94432
PPARG peroxisome proliferator-activated receptor gamma 2.92732
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.90495
MOK MOK protein kinase 2.9013
UBE2A ubiquitin-conjugating enzyme E2A 2.89015
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.85238
CCDC85B coiled-coil domain containing 85B 2.84738
NPDC1 neural proliferation, differentiation and control, 1 2.82775
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.81979
INSIG1 insulin induced gene 1 2.81143
CRTAP cartilage associated protein 2.80094
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.76211
PLSCR1 phospholipid scramblase 1 2.74731
TIAM1 T-cell lymphoma invasion and metastasis 1 2.72073
TRIB1 tribbles pseudokinase 1 2.69575
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.68769
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 2.68356
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.66639
BTK Bruton agammaglobulinemia tyrosine kinase 2.66305
STX1A syntaxin 1A (brain) 2.64815
KEAP1 kelch-like ECH-associated protein 1 2.60823
VAV1 vav 1 guanine nucleotide exchange factor 2.55455
TERT telomerase reverse transcriptase 2.55031
PYGM phosphorylase, glycogen, muscle 2.54175
ATP11B ATPase, class VI, type 11B 2.53615
CD72 CD72 molecule 2.50278
ALDOC aldolase C, fructose-bisphosphate 2.48599
FSTL4 follistatin-like 4 2.48054
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 2.44222
TCTA T-cell leukemia translocation altered 2.4406
TWF2 twinfilin actin binding protein 2 2.42468
HBA1 hemoglobin, alpha 1 2.42009
PFKL phosphofructokinase, liver 2.41233
IL12A interleukin 12A 2.40688
DUSP5 dual specificity phosphatase 5 2.39895
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.39017
MARCHF3 membrane associated ring-CH-type finger 3 2.36857
ZNF267 zinc finger protein 267 2.35684
DUSP2 dual specificity phosphatase 2 2.34273
FFAR1 free fatty acid receptor 1 2.3401
NABP1 nucleic acid binding protein 1 2.33789
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.3129
SH2B2 SH2B adaptor protein 2 2.3091
BCL2 B-cell CLL/lymphoma 2 2.29419
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.28499
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.27748
OXCT1 3-oxoacid CoA transferase 1 2.27414
FKBP14 FK506 binding protein 14, 22 kDa 2.26507
TEC tec protein tyrosine kinase 2.25603
CCDC81 coiled-coil domain containing 81 2.2478
KCTD11 potassium channel tetramerization domain containing 11 2.24276
BLMH bleomycin hydrolase 2.23711
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.23092
NUP153 nucleoporin 153kDa 2.21601
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.21427
RTP4 receptor (chemosensory) transporter protein 4 2.21228
FDXR ferredoxin reductase 2.21179
LPAR2 lysophosphatidic acid receptor 2 2.20999
CLIP2 CAP-GLY domain containing linker protein 2 2.20716
JADE2 jade family PHD finger 2 2.20705
BCAS4 breast carcinoma amplified sequence 4 2.20344
HOXA1 homeobox A1 2.20109
DPF3 D4, zinc and double PHD fingers, family 3 2.15523
CYCS cytochrome c, somatic 2.13847
MAPKBP1 mitogen-activated protein kinase binding protein 1 2.12679
JMJD1C jumonji domain containing 1C 2.12122
RCVRN recoverin 2.11068
IL19 interleukin 19 2.10591
CEMIP2 cell migration inducing hyaluronidase 2 2.08561
SETX senataxin 2.08418
AK8 adenylate kinase 8 2.08111
FLRT1 fibronectin leucine rich transmembrane protein 1 2.07925
CFAP46 cilia and flagella associated protein 46 2.06713
PAX7 paired box 7 2.06326
MYOZ3 myozenin 3 2.06119
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 2.05767
ZNF507 zinc finger protein 507 2.05275
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 2.04649
AIM2 absent in melanoma 2 2.04544
TRHR thyrotropin-releasing hormone receptor 2.03545
SEC31B SEC31 homolog B (S. cerevisiae) 2.03288
ZBTB44 zinc finger and BTB domain containing 44 2.03176
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.03168
TECPR2 tectonin beta-propeller repeat containing 2 2.03079
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 2.02695
EDA2R ectodysplasin A2 receptor 2.02204
LDAF1 lipid droplet assembly factor 1 2.02114
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 2.00792
IFI44L interferon-induced protein 44-like 2.00613

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -6.60006
PECR peroxisomal trans-2-enoyl-CoA reductase -6.03946
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -5.76774
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.65634
GNAS GNAS complex locus -4.61387
PSRC1 proline/serine-rich coiled-coil 1 -4.37507
CD320 CD320 molecule -4.28924
CBR1 carbonyl reductase 1 -4.25077
HAT1 histone acetyltransferase 1 -4.13481
TSEN2 TSEN2 tRNA splicing endonuclease subunit -4.04572
OXA1L oxidase (cytochrome c) assembly 1-like -3.80397
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.66758
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.66406
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -3.5112
ARID5B AT rich interactive domain 5B (MRF1-like) -3.4424
TRAPPC3 trafficking protein particle complex 3 -3.43821
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.35407
SCAND1 SCAN domain containing 1 -3.34614
DPH2 DPH2 homolog (S. cerevisiae) -3.13819
TUBB6 tubulin, beta 6 class V -3.13732
COG2 component of oligomeric golgi complex 2 -3.12661
VAT1 vesicle amine transport 1 -3.08473
SARS1 seryl-tRNA synthetase 1 -2.98061
TNIP1 TNFAIP3 interacting protein 1 -2.97986
MCOLN1 mucolipin 1 -2.94097
DDA1 DET1 and DDB1 associated 1 -2.9077
HAX1 HCLS1 associated protein X-1 -2.86241
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.80129
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.78
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.73362
ZMIZ1 zinc finger, MIZ-type containing 1 -2.69905
TLR4 toll-like receptor 4 -2.65596
TMEM109 transmembrane protein 109 -2.6473
TOR1A torsin family 1, member A (torsin A) -2.63944
ILK integrin-linked kinase -2.62663
TCEAL4 transcription elongation factor A (SII)-like 4 -2.58006
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.50794
EDN3 endothelin 3 -2.4975
ZNF205 zinc finger protein 205 -2.4837
NR1H2 nuclear receptor subfamily 1, group H, member 2 -2.46773
DHPS deoxyhypusine synthase -2.40064
PDZD2 PDZ domain containing 2 -2.39584
RNF41 ring finger protein 41, E3 ubiquitin protein ligase -2.33584
GABARAP GABA(A) receptor-associated protein -2.33521
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.32626
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I -2.32569
TLN1 talin 1 -2.30294
PYCR1 pyrroline-5-carboxylate reductase 1 -2.30113
WDR7 WD repeat domain 7 -2.28191
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.27147
HPCA hippocalcin -2.27044
LOC102724560 cystathionine beta-synthase -2.26749
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.26536
MLF2 myeloid leukemia factor 2 -2.26417
SCN3A sodium channel, voltage gated, type III alpha subunit -2.25784
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.22565
CDK11A cyclin-dependent kinase 11A -2.18572
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.17864
ZNF586 zinc finger protein 586 -2.17531
SLC35E2B solute carrier family 35, member E2B -2.17252
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A -2.15448
RNF5 ring finger protein 5, E3 ubiquitin protein ligase -2.15422
TMEM184C transmembrane protein 184C -2.15377
ARPP19 cAMP-regulated phosphoprotein, 19kDa -2.15284
SSR4 signal sequence receptor, delta -2.13859
MRPL34 mitochondrial ribosomal protein L34 -2.1282
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.12763
PFDN1 prefoldin subunit 1 -2.12711
FABP1 fatty acid binding protein 1, liver -2.12081
LIMD2 LIM domain containing 2 -2.10301
MED21 mediator complex subunit 21 -2.10127
BEX3 brain expressed X-linked 3 -2.09846
MELK maternal embryonic leucine zipper kinase -2.09543
SKIC2 SKI2 subunit of superkiller complex -2.09412
INTS12 integrator complex subunit 12 -2.08396
MARCHF2 membrane associated ring-CH-type finger 2 -2.07454
SNX4 sorting nexin 4 -2.0692
ALOX5AP arachidonate 5-lipoxygenase-activating protein -2.06707
CNBP CCHC-type zinc finger, nucleic acid binding protein -2.06298
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit -2.05759
RNF130 ring finger protein 130 -2.04219
LAGE3 L antigen family, member 3 -2.03876
NUP42 nucleoporin 42 -2.03303
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa -2.0298
RPRD1A regulation of nuclear pre-mRNA domain containing 1A -2.02846
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 -2.02294
ARPP21 cAMP-regulated phosphoprotein, 21kDa -2.02179
PLD3 phospholipase D family, member 3 -2.01682
MYH10 myosin, heavy chain 10, non-muscle -2.00962
ANGPTL3 angiopoietin-like 3 -2.00926