CRCGN014_HEPG2_3H:K05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description geldanamycin 10.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

146 genes differentially expressed following the CRCGN014_HEPG2_3H:K05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 10.0
HSPA1A heat shock 70kDa protein 1A 9.8258
BAG3 BCL2-associated athanogene 3 6.62227
MAMLD1 mastermind-like domain containing 1 6.28616
MAP7 microtubule-associated protein 7 5.90056
PEX11A peroxisomal biogenesis factor 11 alpha 5.37481
KDM5A lysine (K)-specific demethylase 5A 4.68135
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 4.67454
HSPA1B heat shock 70kDa protein 1B 4.55424
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 4.54391
VGLL4 vestigial-like family member 4 4.36794
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.21067
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.14936
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.78374
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.76305
AARS1 alanyl-tRNA synthetase 1 3.6545
VAV3 vav 3 guanine nucleotide exchange factor 3.48389
HYOU1 hypoxia up-regulated 1 3.38125
ZNF589 zinc finger protein 589 3.3184
HSPA1L heat shock 70kDa protein 1-like 3.28697
HPRT1 hypoxanthine phosphoribosyltransferase 1 3.20595
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 3.1898
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.14977
CFAP44 cilia and flagella associated protein 44 3.01016
ADRB2 adrenoceptor beta 2, surface 3.008
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.00781
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 2.97119
NUCB2 nucleobindin 2 2.92337
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.9125
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.91037
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.85875
ABHD4 abhydrolase domain containing 4 2.82496
NOSIP nitric oxide synthase interacting protein 2.81524
HSPB1 heat shock 27kDa protein 1 2.80905
SLC35B1 solute carrier family 35, member B1 2.77711
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.75491
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.73287
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.70583
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.6483
FZD2 frizzled class receptor 2 2.64536
TIAM1 T-cell lymphoma invasion and metastasis 1 2.623
HSPA6 heat shock 70kDa protein 6 (HSP70B') 2.60878
CPEB3 cytoplasmic polyadenylation element binding protein 3 2.58068
EVL Enah/Vasp-like 2.56607
SFTPB surfactant protein B 2.53532
GPATCH8 G patch domain containing 8 2.51182
MINDY1 MINDY lysine 48 deubiquitinase 1 2.50857
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.41849
CINP cyclin-dependent kinase 2 interacting protein 2.37921
KLHL12 kelch-like family member 12 2.37896
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 2.36021
EDDM3B epididymal protein 3B 2.35565
WDR33 WD repeat domain 33 2.33657
TAS2R10 taste receptor, type 2, member 10 2.32756
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.31826
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 2.31533
TTBK2 tau tubulin kinase 2 2.30083
PRKCH protein kinase C, eta 2.28971
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 2.28255
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.27977
PRR15L proline rich 15-like 2.27032
ZNF442 zinc finger protein 442 2.235
NOTCH1 notch 1 2.22728
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 2.22423
MTM1 myotubularin 1 2.22316
RBBP5 retinoblastoma binding protein 5 2.19403
TGFBI transforming growth factor, beta-induced, 68kDa 2.18151
NLK nemo-like kinase 2.18111
VPS50 VPS50 subunit of EARP/GARPII complex 2.17976
ZNF263 zinc finger protein 263 2.14737
GRB10 growth factor receptor-bound protein 10 2.14655
TOP6BL TOP6B like initiator of meiotic double strand breaks 2.14641
TRIM58 tripartite motif containing 58 2.13241
AKAP17A A kinase (PRKA) anchor protein 17A 2.1307
OR1A1 olfactory receptor, family 1, subfamily A, member 1 2.12679
ADAM10 ADAM metallopeptidase domain 10 2.11954
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2.11829
USP53 ubiquitin specific peptidase 53 2.11523
SYTL2 synaptotagmin-like 2 2.09789
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 2.07808
MAGEB4 melanoma antigen family B4 2.07724
TBC1D10C TBC1 domain family, member 10C 2.06875
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2.0438
SRD5A3 steroid 5 alpha-reductase 3 2.04369
ANKRD36C ankyrin repeat domain 36C 2.04315
MAGEH1 melanoma antigen family H1 2.04174
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 2.03588
SCRN3 secernin 3 2.03423
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 2.03355
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.02775
CXCL2 chemokine (C-X-C motif) ligand 2 2.02598
EGF epidermal growth factor 2.0246
MFSD6 major facilitator superfamily domain containing 6 2.02271
MAGIX MAGI family member, X-linked 2.02053
CCNO cyclin O 2.01552
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) 2.01225
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 2.00334

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.5076
HAT1 histone acetyltransferase 1 -5.25305
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.19414
MAPK13 mitogen-activated protein kinase 13 -5.0889
PCNA proliferating cell nuclear antigen -4.52376
ZMIZ1 zinc finger, MIZ-type containing 1 -4.42846
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.36916
ZDHHC6 zinc finger, DHHC-type containing 6 -4.05976
ELAC2 elaC ribonuclease Z 2 -3.79446
DNM1L dynamin 1-like -3.73182
VDAC1 voltage-dependent anion channel 1 -3.3302
FASTKD5 FAST kinase domains 5 -3.27161
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.25211
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.17329
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -3.16397
ETFB electron-transfer-flavoprotein, beta polypeptide -3.13214
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.76899
VAT1 vesicle amine transport 1 -2.75903
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.73482
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.71161
GLOD4 glyoxalase domain containing 4 -2.66968
RPIA ribose 5-phosphate isomerase A -2.55305
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.50502
CCNB1 cyclin B1 -2.49941
KREMEN2 kringle containing transmembrane protein 2 -2.46339
CDC20 cell division cycle 20 -2.43849
CD248 CD248 molecule, endosialin -2.42855
EMILIN1 elastin microfibril interfacer 1 -2.3816
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.37925
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.33481
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.31305
CLEC11A C-type lectin domain family 11, member A -2.27478
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.25079
CCNB2 cyclin B2 -2.17239
PCCB propionyl CoA carboxylase, beta polypeptide -2.14385
PGAM4 phosphoglycerate mutase family member 4 -2.12863
CDCA3 cell division cycle associated 3 -2.0962
DENND10 DENN domain containing 10 -2.08119
PENK proenkephalin -2.07801
LRP3 low density lipoprotein receptor-related protein 3 -2.0772
PLK1 polo-like kinase 1 -2.06711
TCEAL4 transcription elongation factor A (SII)-like 4 -2.06475
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.05318
CIDEA cell death-inducing DFFA-like effector a -2.04148
CCNH cyclin H -2.03879
THAP11 THAP domain containing 11 -2.02598
SMNDC1 survival motor neuron domain containing 1 -2.01936
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.0177
PHOX2A paired-like homeobox 2a -2.00261