CRCGN014_HEPG2_3H:K06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description geldanamycin 5.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

128 genes differentially expressed following the CRCGN014_HEPG2_3H:K06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 10.0
HSPA1A heat shock 70kDa protein 1A 9.00099
BAG3 BCL2-associated athanogene 3 8.077
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 5.69686
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.42727
HSPA1B heat shock 70kDa protein 1B 4.38653
TIAM1 T-cell lymphoma invasion and metastasis 1 4.32236
TBC1D10C TBC1 domain family, member 10C 4.04514
AARS1 alanyl-tRNA synthetase 1 3.96417
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.78536
CXCL2 chemokine (C-X-C motif) ligand 2 3.63085
SLC35B1 solute carrier family 35, member B1 3.52835
STIMATE STIM activating enhancer 3.45273
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.30794
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.25281
HYOU1 hypoxia up-regulated 1 3.1597
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.14307
TRIB3 tribbles pseudokinase 3 3.08229
UBQLN2 ubiquilin 2 3.0572
FRS2 fibroblast growth factor receptor substrate 2 3.04718
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.92427
ZBTB18 zinc finger and BTB domain containing 18 2.91935
ADGRE5 adhesion G protein-coupled receptor E5 2.89889
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.88285
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.85516
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.81208
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.78406
JMJD6 jumonji domain containing 6 2.75786
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 2.75467
GOLT1B golgi transport 1B 2.6487
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.51194
ABHD4 abhydrolase domain containing 4 2.4783
HSPB1 heat shock 27kDa protein 1 2.41773
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.38772
CYCS cytochrome c, somatic 2.37679
MED17 mediator complex subunit 17 2.35825
HSPH1 heat shock 105kDa/110kDa protein 1 2.35726
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.34117
TP53 tumor protein p53 2.34057
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.33637
BTK Bruton agammaglobulinemia tyrosine kinase 2.29735
MAP7 microtubule-associated protein 7 2.29195
RBM15B RNA binding motif protein 15B 2.28618
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.28392
NT5C2 5'-nucleotidase, cytosolic II 2.2645
MCUR1 mitochondrial calcium uniporter regulator 1 2.24165
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.23003
CEP57 centrosomal protein 57kDa 2.21553
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.21224
ACBD3 acyl-CoA binding domain containing 3 2.2036
RPP30 ribonuclease P/MRP 30kDa subunit 2.18803
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.17042
YARS1 tyrosyl-tRNA synthetase 1 2.14595
SAA2 serum amyloid A2 2.14266
TM9SF3 transmembrane 9 superfamily member 3 2.13109
TARS1 threonyl-tRNA synthetase 1 2.12865
XPOT exportin, tRNA 2.12752
MANF mesencephalic astrocyte-derived neurotrophic factor 2.12681
NUCB2 nucleobindin 2 2.11135
LOC128125814 uncharacterized LOC128125814 2.07584
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 2.07064
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.06222
LPAR2 lysophosphatidic acid receptor 2 2.05547
TATDN2 TatD DNase domain containing 2 2.03305
STXBP2 syntaxin binding protein 2 2.03032
SEC16A SEC16 homolog A (S. cerevisiae) 2.02657
COPG1 coatomer protein complex, subunit gamma 1 2.01933
GARS1 glycyl-tRNA synthetase 1 2.00984

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
VAT1 vesicle amine transport 1 -6.61242
LDHD lactate dehydrogenase D -6.4009
PCNA proliferating cell nuclear antigen -4.48548
CASP3 caspase 3, apoptosis-related cysteine peptidase -4.4691
EIF5 eukaryotic translation initiation factor 5 -4.07757
CCDC86 coiled-coil domain containing 86 -3.90697
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.37363
GRWD1 glutamate-rich WD repeat containing 1 -3.35866
DNM1L dynamin 1-like -3.31701
CCNB2 cyclin B2 -3.29277
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.21394
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.96903
TLR4 toll-like receptor 4 -2.93252
RAI14 retinoic acid induced 14 -2.87332
CDC25B cell division cycle 25B -2.83933
NT5DC2 5'-nucleotidase domain containing 2 -2.68028
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.59906
MAPK13 mitogen-activated protein kinase 13 -2.59501
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -2.58401
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.51743
THSD7A thrombospondin, type I, domain containing 7A -2.48418
HADH hydroxyacyl-CoA dehydrogenase -2.44605
BPHL biphenyl hydrolase-like (serine hydrolase) -2.40919
GNAS GNAS complex locus -2.39813
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 -2.39091
FAM234B family with sequence similarity 234 member B -2.36333
MAP3K11 mitogen-activated protein kinase kinase kinase 11 -2.35841
OXA1L oxidase (cytochrome c) assembly 1-like -2.34198
SLC35F2 solute carrier family 35, member F2 -2.32515
GET1 guided entry of tail-anchored proteins factor 1 -2.28208
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.27778
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.25549
TBC1D31 TBC1 domain family, member 31 -2.25255
CSK c-src tyrosine kinase -2.22202
PEX11A peroxisomal biogenesis factor 11 alpha -2.21555
TNK1 tyrosine kinase, non-receptor, 1 -2.18732
AUH AU RNA binding protein/enoyl-CoA hydratase -2.17411
CBR4 carbonyl reductase 4 -2.15672
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -2.15664
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.13134
TRAPPC13 trafficking protein particle complex 13 -2.12827
ZNF280D zinc finger protein 280D -2.12311
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 -2.12141
CHP2 calcineurin-like EF-hand protein 2 -2.12096
GIPC2 GIPC PDZ domain containing family, member 2 -2.11078
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 -2.09705
PARP16 poly (ADP-ribose) polymerase family, member 16 -2.09652
ACLY ATP citrate lyase -2.09309
C2CD2 C2 calcium-dependent domain containing 2 -2.08928
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.08452
ERCC5 excision repair cross-complementation group 5 -2.0836
ELAC2 elaC ribonuclease Z 2 -2.08046
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.07528
TAGLN3 transgelin 3 -2.05039
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -2.0406
PCCA propionyl CoA carboxylase, alpha polypeptide -2.03141
SLC35E2B solute carrier family 35, member E2B -2.02476
CLCA1 chloride channel accessory 1 -2.01877
NUP205 nucleoporin 205kDa -2.00093