CRCGN014_HEPG2_3H:K08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-thiodianiline 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN014_HEPG2_3H:K08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 7.43805
CXCL2 chemokine (C-X-C motif) ligand 2 6.54394
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.93805
MYLK myosin light chain kinase 4.4207
GSTZ1 glutathione S-transferase zeta 1 4.0556
INTS3 integrator complex subunit 3 3.91623
CYCS cytochrome c, somatic 3.82276
BACE2 beta-site APP-cleaving enzyme 2 3.69813
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.58662
ADRB2 adrenoceptor beta 2, surface 3.40293
PRKCH protein kinase C, eta 3.29954
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.77662
TBP TATA box binding protein 2.76572
BAX BCL2-associated X protein 2.7631
EVL Enah/Vasp-like 2.73217
ANO1 anoctamin 1, calcium activated chloride channel 2.68962
MAMLD1 mastermind-like domain containing 1 2.63282
STXBP2 syntaxin binding protein 2 2.55074
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.54235
GOLGA7 golgin A7 2.44449
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.40054
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.36455
NPDC1 neural proliferation, differentiation and control, 1 2.36318
TPD52L2 tumor protein D52-like 2 2.32092
LGALSL lectin, galactoside-binding-like 2.24667
ARID4B AT rich interactive domain 4B (RBP1-like) 2.23219
TULP4 tubby like protein 4 2.21305
EGF epidermal growth factor 2.11082
GLO1 glyoxalase I 2.07534
TIAM1 T-cell lymphoma invasion and metastasis 1 2.05862
MCUR1 mitochondrial calcium uniporter regulator 1 2.04746

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -8.49841
GOLT1B golgi transport 1B -6.2484
CCNB2 cyclin B2 -4.75843
EIF5 eukaryotic translation initiation factor 5 -3.81988
OXA1L oxidase (cytochrome c) assembly 1-like -3.6226
CCNB1 cyclin B1 -3.23395
FBXL12 F-box and leucine-rich repeat protein 12 -3.22004
CCNH cyclin H -3.17288
TRIB3 tribbles pseudokinase 3 -3.12661
PRPF4 pre-mRNA processing factor 4 -3.02851
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.84646
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.8369
BIRC2 baculoviral IAP repeat containing 2 -2.50745
LRRC47 leucine rich repeat containing 47 -2.23662
HSPA8 heat shock 70kDa protein 8 -2.22502
HLA-DMA major histocompatibility complex, class II, DM alpha -2.11718
OGN osteoglycin -2.10876
ICAM3 intercellular adhesion molecule 3 -2.09242
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma -2.02238
SEC24B SEC24 family member B -2.00372