CRCGN014_HEPG2_3H:K09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (2s)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid 20.17 um perturbation at 3 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

92 genes differentially expressed following the CRCGN014_HEPG2_3H:K09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.50304
CXCL2 chemokine (C-X-C motif) ligand 2 6.32551
SNAP25 synaptosomal-associated protein, 25kDa 5.74202
CCL2 chemokine (C-C motif) ligand 2 5.03455
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.60478
ATP11B ATPase, class VI, type 11B 4.247
CGRRF1 cell growth regulator with ring finger domain 1 4.00167
PMM2 phosphomannomutase 2 3.57595
CHMP6 charged multivesicular body protein 6 3.53062
TREM1 triggering receptor expressed on myeloid cells 1 3.46953
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.41296
CSK c-src tyrosine kinase 3.38915
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.38195
CARMIL1 capping protein regulator and myosin 1 linker 1 3.27211
MAMLD1 mastermind-like domain containing 1 3.25048
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.15437
KIFBP kinesin family binding protein 3.08809
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.94137
ADRB2 adrenoceptor beta 2, surface 2.82323
RAP1GAP RAP1 GTPase activating protein 2.69082
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.68482
LOC122526780 uncharacterized LOC122526780 2.63441
CYCS cytochrome c, somatic 2.61735
STIMATE STIM activating enhancer 2.61602
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.6102
EVL Enah/Vasp-like 2.57136
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.56018
RXYLT1 ribitol xylosyltransferase 1 2.54216
CDC25B cell division cycle 25B 2.42004
TEX10 testis expressed 10 2.39471
FZD7 frizzled class receptor 7 2.36024
CEP57 centrosomal protein 57kDa 2.3489
VGLL4 vestigial-like family member 4 2.32854
FCHO1 FCH domain only 1 2.3078
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.30716
SV2C synaptic vesicle glycoprotein 2C 2.27561
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.26995
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 2.26665
PLSCR1 phospholipid scramblase 1 2.24258
GPATCH8 G patch domain containing 8 2.23429
VAT1 vesicle amine transport 1 2.20551
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 2.18177
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.17536
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 2.17218
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 2.16846
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 2.15159
SAA2 serum amyloid A2 2.13663
ABHD6 abhydrolase domain containing 6 2.13217
OCA2 oculocutaneous albinism II 2.11323
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 2.0983
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.09615
KDM4D lysine (K)-specific demethylase 4D 2.07572
ICMT isoprenylcysteine carboxyl methyltransferase 2.06749
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 2.06737
GRM6 glutamate receptor, metabotropic 6 2.05109
MAP7 microtubule-associated protein 7 2.03026
SORBS3 sorbin and SH3 domain containing 3 2.00665

decreased expression

Symbol Name Standardized Value
CASP7 caspase 7, apoptosis-related cysteine peptidase -6.26861
CDC20 cell division cycle 20 -5.86627
OXA1L oxidase (cytochrome c) assembly 1-like -5.30123
PRPF4 pre-mRNA processing factor 4 -4.60797
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.86736
LAP3 leucine aminopeptidase 3 -3.8149
ZNF586 zinc finger protein 586 -3.51034
COG2 component of oligomeric golgi complex 2 -3.36412
CCNB2 cyclin B2 -3.32613
ZMIZ1 zinc finger, MIZ-type containing 1 -3.3241
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.26004
TRIB3 tribbles pseudokinase 3 -3.10778
GOLT1B golgi transport 1B -3.07403
DNM1L dynamin 1-like -3.0535
DCK deoxycytidine kinase -3.03642
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.79857
NGRN neugrin, neurite outgrowth associated -2.76705
NVL nuclear VCP-like -2.64618
FADS2 fatty acid desaturase 2 -2.56476
RNF167 ring finger protein 167 -2.38772
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.38746
BCL2L2 BCL2-like 2 -2.37775
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.25514
CTSD cathepsin D -2.22594
WDR7 WD repeat domain 7 -2.1999
VEGFA vascular endothelial growth factor A -2.16807
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -2.15127
CLIP2 CAP-GLY domain containing linker protein 2 -2.15005
SH3GLB2 SH3-domain GRB2-like endophilin B2 -2.12404
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.06235
MED28 mediator complex subunit 28 -2.05957
YME1L1 YME1-like 1 ATPase -2.05713
ELOVL1 ELOVL fatty acid elongase 1 -2.05376
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.05095
EHBP1L1 EH domain binding protein 1-like 1 -2.0405