CRCGN014_HEPG2_3H:K11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzo(a)pyrene 20.18 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

96 genes differentially expressed following the CRCGN014_HEPG2_3H:K11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 7.38014
CEP57 centrosomal protein 57kDa 5.03249
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.57306
ADGRE5 adhesion G protein-coupled receptor E5 4.4618
EPHB2 EPH receptor B2 4.01657
TREM1 triggering receptor expressed on myeloid cells 1 3.87396
ABHD6 abhydrolase domain containing 6 3.75217
UBQLN2 ubiquilin 2 3.68681
PPARG peroxisome proliferator-activated receptor gamma 3.64056
CBR3 carbonyl reductase 3 3.55487
CIAO3 cytosolic iron-sulfur assembly component 3 3.51069
GPER1 G protein-coupled estrogen receptor 1 3.47305
AMDHD2 amidohydrolase domain containing 2 3.35823
BAMBI BMP and activin membrane-bound inhibitor 3.30483
CARMIL1 capping protein regulator and myosin 1 linker 1 3.20691
PRKCH protein kinase C, eta 3.06682
TIAM1 T-cell lymphoma invasion and metastasis 1 2.84257
ANKRD49 ankyrin repeat domain 49 2.73728
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.68435
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 2.65173
DIPK1A divergent protein kinase domain 1A 2.63981
FSD1 fibronectin type III and SPRY domain containing 1 2.63101
ZNF528 zinc finger protein 528 2.56655
ADGRB1 adhesion G protein-coupled receptor B1 2.56319
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C 2.5393
DYNLT3 dynein, light chain, Tctex-type 3 2.52746
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.51865
KIF20A kinesin family member 20A 2.46766
GPATCH8 G patch domain containing 8 2.43081
SPDEF SAM pointed domain containing ETS transcription factor 2.38803
PHAF1 phagosome assembly factor 1 2.33002
MAP3K10 mitogen-activated protein kinase kinase kinase 10 2.32238
TCTN2 tectonic family member 2 2.2912
WDTC1 WD and tetratricopeptide repeats 1 2.26875
FGF6 fibroblast growth factor 6 2.26846
VWA7 von Willebrand factor A domain containing 7 2.26821
GAST gastrin 2.26496
ZNF747 zinc finger protein 747 2.25945
CBY1 chibby homolog 1 (Drosophila) 2.25903
MXD3 MAX dimerization protein 3 2.22239
SNX15 sorting nexin 15 2.20693
CCL24 chemokine (C-C motif) ligand 24 2.19788
MUC6 mucin 6, oligomeric mucus/gel-forming 2.18034
JRKL JRK-like 2.17443
FEV FEV (ETS oncogene family) 2.17441
RAP1GAP RAP1 GTPase activating protein 2.16233
CHEK2 checkpoint kinase 2 2.1465
GBX1 gastrulation brain homeobox 1 2.14294
KLHL1 kelch-like family member 1 2.14276
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 2.13831
LMX1B LIM homeobox transcription factor 1, beta 2.1365
YIPF1 Yip1 domain family, member 1 2.11244
GRK1 G protein-coupled receptor kinase 1 2.1099
ALX4 ALX homeobox 4 2.10303
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 2.10119
HEYL hes-related family bHLH transcription factor with YRPW motif-like 2.07138
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 2.07013
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 2.06603
NPY neuropeptide Y 2.05385
HAND1 heart and neural crest derivatives expressed 1 2.05074
RAX retina and anterior neural fold homeobox 2.0498
A4GALT alpha 1,4-galactosyltransferase 2.0469
STRA6 stimulated by retinoic acid 6 2.0344
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase 2.03264
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.03123
FBXO31 F-box protein 31 2.01201
DEFA6 defensin, alpha 6, Paneth cell-specific 2.0102
SIGLEC15 sialic acid binding Ig-like lectin 15 2.0099
POMT2 protein-O-mannosyltransferase 2 2.00856

decreased expression

Symbol Name Standardized Value
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -8.61033
ACAA1 acetyl-CoA acyltransferase 1 -4.75728
LAP3 leucine aminopeptidase 3 -4.45436
PCCB propionyl CoA carboxylase, beta polypeptide -4.01314
LDHD lactate dehydrogenase D -3.92236
PCNA proliferating cell nuclear antigen -3.61223
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -3.55135
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.50849
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.46536
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.04444
MAPK13 mitogen-activated protein kinase 13 -2.93433
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.86407
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.73517
EIF5 eukaryotic translation initiation factor 5 -2.65035
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.47448
TRIB3 tribbles pseudokinase 3 -2.47281
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.41484
TLCD3A TLC domain containing 3A -2.37621
TUBB6 tubulin, beta 6 class V -2.36879
ZNF586 zinc finger protein 586 -2.29825
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.20762
ZNF146 zinc finger protein 146 -2.18602
LCAT lecithin-cholesterol acyltransferase -2.17448
OXA1L oxidase (cytochrome c) assembly 1-like -2.09653
HSPA8 heat shock 70kDa protein 8 -2.07319
EXOC3 exocyst complex component 3 -2.0378
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.01332