CRCGN014_HEPG2_3H:K12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-nitro-o-phenylenediamine 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

52 genes differentially expressed following the CRCGN014_HEPG2_3H:K12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD4 abhydrolase domain containing 4 5.49178
MAP7 microtubule-associated protein 7 5.44185
HMOX1 heme oxygenase 1 5.182
CHMP6 charged multivesicular body protein 6 5.04277
TXNRD1 thioredoxin reductase 1 4.95595
LCN2 lipocalin 2 4.52028
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.41531
GPER1 G protein-coupled estrogen receptor 1 4.2747
ATP11B ATPase, class VI, type 11B 3.81078
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.68416
STK10 serine/threonine kinase 10 3.67289
MINDY1 MINDY lysine 48 deubiquitinase 1 3.53779
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.30394
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.18685
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.97812
CSK c-src tyrosine kinase 2.86559
SQSTM1 sequestosome 1 2.78456
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.75741
H2BC21 H2B clustered histone 21 2.73609
STIMATE STIM activating enhancer 2.72499
EPHA3 EPH receptor A3 2.55113
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.52927
KEAP1 kelch-like ECH-associated protein 1 2.47742
TERT telomerase reverse transcriptase 2.45492
TIAM1 T-cell lymphoma invasion and metastasis 1 2.44233
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.29545
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.29257
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.21678
ABHD6 abhydrolase domain containing 6 2.18593
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.14353
RAB31 RAB31, member RAS oncogene family 2.13651
KLHL21 kelch-like family member 21 2.11418
KLHL9 kelch-like family member 9 2.01225
FOSL1 FOS-like antigen 1 2.00704

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -6.73661
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.5828
ZNF586 zinc finger protein 586 -5.34096
PCCB propionyl CoA carboxylase, beta polypeptide -4.08267
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.73183
PCNA proliferating cell nuclear antigen -3.69669
C2CD5 C2 calcium-dependent domain containing 5 -3.5624
CDC20 cell division cycle 20 -3.27525
FAIM Fas apoptotic inhibitory molecule -3.1339
CCNB2 cyclin B2 -2.79942
GLOD4 glyoxalase domain containing 4 -2.63642
ACOT9 acyl-CoA thioesterase 9 -2.61694
HAT1 histone acetyltransferase 1 -2.57789
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.46962
YME1L1 YME1-like 1 ATPase -2.45216
GNAS GNAS complex locus -2.30027
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.27983
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.14962