CRCGN014_HEPG2_3H:K14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-chloroaniline 40.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

35 genes differentially expressed following the CRCGN014_HEPG2_3H:K14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 7.39801
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 7.34102
NOTCH1 notch 1 5.35816
CARMIL1 capping protein regulator and myosin 1 linker 1 5.21115
MAP7 microtubule-associated protein 7 4.88265
DYNLT3 dynein, light chain, Tctex-type 3 4.04209
CXCL2 chemokine (C-X-C motif) ligand 2 3.90043
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.77679
RPP38 ribonuclease P/MRP 38kDa subunit 3.61024
CHN1 chimerin 1 3.51939
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.48846
JADE2 jade family PHD finger 2 3.37692
BTK Bruton agammaglobulinemia tyrosine kinase 3.26679
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.1971
MYLK myosin light chain kinase 2.88335
GARRE1 granule associated Rac and RHOG effector 1 2.47736
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.40958
WFS1 Wolfram syndrome 1 (wolframin) 2.29732
CEP57 centrosomal protein 57kDa 2.19833
CHEK2 checkpoint kinase 2 2.16162
SSBP2 single-stranded DNA binding protein 2 2.12244
POMP proteasome maturation protein 2.11489
PRDX1 peroxiredoxin 1 2.09312
EGF epidermal growth factor 2.04396
SIRT3 sirtuin 3 2.04022
TPCN1 two pore segment channel 1 2.00193

decreased expression

Symbol Name Standardized Value
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -6.04975
CCNB2 cyclin B2 -3.60968
TRIB3 tribbles pseudokinase 3 -2.94089
MXI1 MAX interactor 1, dimerization protein -2.42282
UGDH UDP-glucose 6-dehydrogenase -2.41121
VAT1 vesicle amine transport 1 -2.20526
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 -2.09303
NALF2 NALCN channel auxiliary factor 2 -2.04524
ZNF586 zinc finger protein 586 -2.04035