CRCGN014_HEPG2_3H:K15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description succinic anhydride 40.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN014_HEPG2_3H:K15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 6.54975
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.25764
GSTZ1 glutathione S-transferase zeta 1 5.00625
ADRB2 adrenoceptor beta 2, surface 4.10722
E2F2 E2F transcription factor 2 4.10107
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.83756
DENND2D DENN/MADD domain containing 2D 3.76755
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.73934
CXCL2 chemokine (C-X-C motif) ligand 2 3.61371
MAMLD1 mastermind-like domain containing 1 3.5096
PPARG peroxisome proliferator-activated receptor gamma 3.16675
MAP7 microtubule-associated protein 7 2.85828
NOTCH1 notch 1 2.77257
BAX BCL2-associated X protein 2.72066
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.63988
EPN2 epsin 2 2.49833
ABHD6 abhydrolase domain containing 6 2.42285
WASF3 WAS protein family, member 3 2.40067
UBE2A ubiquitin-conjugating enzyme E2A 2.35705
PFKL phosphofructokinase, liver 2.31391
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.30339
CORO1A coronin, actin binding protein, 1A 2.27966
MTA2 metastasis associated 1 family, member 2 2.2257
SATB1 SATB homeobox 1 2.21964
ANO10 anoctamin 10 2.16526
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.14963
CEP57 centrosomal protein 57kDa 2.14542
LASP1 LIM and SH3 protein 1 2.12972
ZNF589 zinc finger protein 589 2.0622
TESK1 testis-specific kinase 1 2.04231

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -6.82113
FAIM Fas apoptotic inhibitory molecule -6.72945
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -6.47555
ADI1 acireductone dioxygenase 1 -6.41187
PRPF4 pre-mRNA processing factor 4 -5.61367
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.74143
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -3.65937
LDHD lactate dehydrogenase D -3.55283
CDC20 cell division cycle 20 -3.15878
TLR4 toll-like receptor 4 -3.15503
KDM3A lysine (K)-specific demethylase 3A -2.90786
MAPK13 mitogen-activated protein kinase 13 -2.82106
PCNA proliferating cell nuclear antigen -2.25289
HOOK3 hook microtubule-tethering protein 3 -2.19415
RFC2 replication factor C (activator 1) 2, 40kDa -2.11696
TLCD3A TLC domain containing 3A -2.09901
CCNB2 cyclin B2 -2.03845
HEATR1 HEAT repeat containing 1 -2.00891