CRCGN014_HEPG2_3H:K19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-nitrosoazocane 21.1 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN014_HEPG2_3H:K19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 8.22645
SQOR sulfide quinone oxidoreductase 4.82652
MYLK myosin light chain kinase 4.81385
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.35891
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.35812
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.31809
UBQLN2 ubiquilin 2 4.23645
LYN LYN proto-oncogene, Src family tyrosine kinase 4.23091
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.80115
PRKCH protein kinase C, eta 3.55903
CHN1 chimerin 1 3.43736
JADE2 jade family PHD finger 2 3.10497
LPAR2 lysophosphatidic acid receptor 2 3.00775
NPDC1 neural proliferation, differentiation and control, 1 2.92796
GPER1 G protein-coupled estrogen receptor 1 2.89206
SMIM29 small integral membrane protein 29 2.78451
NOTCH1 notch 1 2.73093
SFTPB surfactant protein B 2.70028
CREB1 cAMP responsive element binding protein 1 2.65118
KIF14 kinesin family member 14 2.57328
KIF20A kinesin family member 20A 2.52618
DIPK1A divergent protein kinase domain 1A 2.46068
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.45675
CYCS cytochrome c, somatic 2.37877
HSPA1A heat shock 70kDa protein 1A 2.32886
FCHO1 FCH domain only 1 2.25533
CHMP6 charged multivesicular body protein 6 2.19907
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.1714
TXNL4B thioredoxin-like 4B 2.13002
YIPF5 Yip1 domain family, member 5 2.11645
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 2.00877

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
PCNA proliferating cell nuclear antigen -6.12254
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.39748
CCNB2 cyclin B2 -4.21427
NRIP1 nuclear receptor interacting protein 1 -3.71765
UBE3C ubiquitin protein ligase E3C -3.49212
DNM1L dynamin 1-like -3.22241
CDC25B cell division cycle 25B -3.07354
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.97595
OXA1L oxidase (cytochrome c) assembly 1-like -2.93977
ICAM3 intercellular adhesion molecule 3 -2.83261
SNX11 sorting nexin 11 -2.83155
RGS2 regulator of G-protein signaling 2 -2.74967
MACF1 microtubule-actin crosslinking factor 1 -2.63445
NGRN neugrin, neurite outgrowth associated -2.45895
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.45143
WDR7 WD repeat domain 7 -2.26509
KLHDC8A kelch domain containing 8A -2.13554
PRPF4 pre-mRNA processing factor 4 -2.02474
ACOT8 acyl-CoA thioesterase 8 -2.01063