CRCGN014_HEPG2_3H:K20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cupferron 39.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

106 genes differentially expressed following the CRCGN014_HEPG2_3H:K20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 7.7692
STIMATE STIM activating enhancer 6.16081
TERT telomerase reverse transcriptase 5.66151
SFTPB surfactant protein B 5.48644
GPER1 G protein-coupled estrogen receptor 1 4.80301
PPARG peroxisome proliferator-activated receptor gamma 4.7856
TXNRD1 thioredoxin reductase 1 4.62932
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.54431
CIAO3 cytosolic iron-sulfur assembly component 3 4.52316
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.41143
E2F2 E2F transcription factor 2 4.14081
HMOX1 heme oxygenase 1 4.07131
ABHD4 abhydrolase domain containing 4 3.91607
CXCL2 chemokine (C-X-C motif) ligand 2 3.61522
CSK c-src tyrosine kinase 3.57401
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.54945
HSPA1A heat shock 70kDa protein 1A 3.35175
PRKCH protein kinase C, eta 3.31799
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.25986
CCL2 chemokine (C-C motif) ligand 2 3.16308
ARID4B AT rich interactive domain 4B (RBP1-like) 2.95038
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 2.87946
ATP11B ATPase, class VI, type 11B 2.83515
HLA-DRA major histocompatibility complex, class II, DR alpha 2.67632
WDTC1 WD and tetratricopeptide repeats 1 2.65336
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.58958
PRR15L proline rich 15-like 2.57902
GEMIN8 gem (nuclear organelle) associated protein 8 2.5631
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.51069
PCBP3 poly(rC) binding protein 3 2.46827
GSTZ1 glutathione S-transferase zeta 1 2.45203
TEX10 testis expressed 10 2.44565
EPHX3 epoxide hydrolase 3 2.43075
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 2.42282
CTSE cathepsin E 2.4119
AVPR1B arginine vasopressin receptor 1B 2.4107
GUCA1B guanylate cyclase activator 1B (retina) 2.38364
FGF6 fibroblast growth factor 6 2.36839
GPATCH8 G patch domain containing 8 2.34643
SOX21 SRY (sex determining region Y)-box 21 2.32329
OR1D4 olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene) 2.30291
TEX28 testis expressed 28 2.29526
TEC tec protein tyrosine kinase 2.26025
ADRB2 adrenoceptor beta 2, surface 2.25674
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene) 2.24335
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.2413
GFRA4 GDNF family receptor alpha 4 2.22636
RAB1B RAB1B, member RAS oncogene family 2.22182
ACRV1 acrosomal vesicle protein 1 2.21785
CHRM4 cholinergic receptor, muscarinic 4 2.21688
XKR8 XK, Kell blood group complex subunit-related family, member 8 2.2144
ODAD2 outer dynein arm docking complex subunit 2 2.16285
PRAMEF26 PRAME family member 26 2.15576
IL25 interleukin 25 2.14998
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4 2.14369
H2AP H2A.P histone 2.14364
AFF2 AF4/FMR2 family, member 2 2.13962
FOXN1 forkhead box N1 2.1346
CAPN11 calpain 11 2.12509
AGO4 argonaute RISC catalytic component 4 2.12474
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 2.12165
FKBP14 FK506 binding protein 14, 22 kDa 2.11895
DRD1 dopamine receptor D1 2.10859
CD200R1 CD200 receptor 1 2.10736
BTG4 B-cell translocation gene 4 2.09373
GJA9 gap junction protein, alpha 9, 59kDa 2.08801
CCKAR cholecystokinin A receptor 2.08493
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.07525
KEAP1 kelch-like ECH-associated protein 1 2.06951
OR2H1 olfactory receptor, family 2, subfamily H, member 1 2.0656
ZNRF4 zinc and ring finger 4 2.05481
SRY sex determining region Y 2.04196
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2.04048
FGF3 fibroblast growth factor 3 2.03745
NDE1 nudE neurodevelopment protein 1 2.03737
PLA2G2E phospholipase A2, group IIE 2.03527
CST8 cystatin 8 (cystatin-related epididymal specific) 2.03166
SMCP sperm mitochondria-associated cysteine-rich protein 2.02213
TAS2R1 taste receptor, type 2, member 1 2.01943
KCMF1 potassium channel modulatory factor 1 2.01877
SCN10A sodium channel, voltage gated, type X alpha subunit 2.01772
RGSL1 regulator of G-protein signaling like 1 2.01683
XCR1 chemokine (C motif) receptor 1 2.0079
FAM90A1 family with sequence similarity 90, member A1 2.00635

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -8.08187
PCNA proliferating cell nuclear antigen -7.98233
HAT1 histone acetyltransferase 1 -6.03443
GOLT1B golgi transport 1B -4.60775
ADI1 acireductone dioxygenase 1 -4.20955
COG2 component of oligomeric golgi complex 2 -4.00608
FAIM Fas apoptotic inhibitory molecule -3.97365
TBC1D31 TBC1 domain family, member 31 -3.53281
NRIP1 nuclear receptor interacting protein 1 -3.49339
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.37179
DDIT4 DNA-damage-inducible transcript 4 -3.19641
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.09406
NGRN neugrin, neurite outgrowth associated -2.82492
UGDH UDP-glucose 6-dehydrogenase -2.61812
ZNF586 zinc finger protein 586 -2.60334
WASHC4 WASH complex subunit 4 -2.46513
HSPA13 heat shock protein 70kDa family, member 13 -2.34081
GRWD1 glutamate-rich WD repeat containing 1 -2.25774
FBXL12 F-box and leucine-rich repeat protein 12 -2.25358
LYRM2 LYR motif containing 2 -2.14336
OXA1L oxidase (cytochrome c) assembly 1-like -2.04174
MYL9 myosin, light chain 9, regulatory -2.01141