| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | geldanamycin 2.5 um perturbation at 3 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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147 genes differentially expressed following the CRCGN014_HEPG2_3H:K23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DDIT4 | DNA-damage-inducible transcript 4 | 10.0 |
| HSPA1A | heat shock 70kDa protein 1A | 10.0 |
| BAG3 | BCL2-associated athanogene 3 | 7.95047 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 6.5571 |
| PPARG | peroxisome proliferator-activated receptor gamma | 6.47755 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 6.13653 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 5.58082 |
| LPAR2 | lysophosphatidic acid receptor 2 | 4.33568 |
| PNKP | polynucleotide kinase 3'-phosphatase | 4.00035 |
| HSPA1B | heat shock 70kDa protein 1B | 3.80458 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 3.70819 |
| LCN2 | lipocalin 2 | 3.6645 |
| GPATCH8 | G patch domain containing 8 | 3.63664 |
| AARS1 | alanyl-tRNA synthetase 1 | 3.60742 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 3.5191 |
| HYOU1 | hypoxia up-regulated 1 | 3.48239 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 3.47994 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 3.4714 |
| TRIB3 | tribbles pseudokinase 3 | 3.46361 |
| JADE2 | jade family PHD finger 2 | 3.43831 |
| UBQLN2 | ubiquilin 2 | 3.24478 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 3.12899 |
| RPL39L | ribosomal protein L39-like | 3.09454 |
| SFTPB | surfactant protein B | 3.08192 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 3.02521 |
| CYCS | cytochrome c, somatic | 3.01007 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.98743 |
| NUCB2 | nucleobindin 2 | 2.96504 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | 2.92916 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 2.85647 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 2.7365 |
| FZD2 | frizzled class receptor 2 | 2.67493 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 2.65118 |
| SCRN1 | secernin 1 | 2.63496 |
| HSPB1 | heat shock 27kDa protein 1 | 2.62536 |
| CEP57 | centrosomal protein 57kDa | 2.62094 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 2.61702 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 2.60665 |
| TRIP6 | thyroid hormone receptor interactor 6 | 2.45744 |
| CNPY3 | canopy FGF signaling regulator 3 | 2.45674 |
| TP53 | tumor protein p53 | 2.40417 |
| SLC35B1 | solute carrier family 35, member B1 | 2.3575 |
| C5 | complement component 5 | 2.34237 |
| DUSP2 | dual specificity phosphatase 2 | 2.33966 |
| GOLT1B | golgi transport 1B | 2.33922 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 2.31881 |
| FRS2 | fibroblast growth factor receptor substrate 2 | 2.2934 |
| TEX10 | testis expressed 10 | 2.24867 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | 2.23927 |
| STATH | statherin | 2.22945 |
| CSRP1 | cysteine and glycine-rich protein 1 | 2.22781 |
| TBP | TATA box binding protein | 2.19784 |
| SH2D2A | SH2 domain containing 2A | 2.19735 |
| RPP30 | ribonuclease P/MRP 30kDa subunit | 2.19721 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 2.15836 |
| GARS1 | glycyl-tRNA synthetase 1 | 2.13082 |
| UFM1 | ubiquitin-fold modifier 1 | 2.12987 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 2.12899 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 2.12707 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 2.10571 |
| LOC128125814 | uncharacterized LOC128125814 | 2.09982 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 2.09684 |
| FKBP14 | FK506 binding protein 14, 22 kDa | 2.08819 |
| PRKD2 | protein kinase D2 | 2.08484 |
| TPD52L2 | tumor protein D52-like 2 | 2.06187 |
| NCBP3 | nuclear cap binding subunit 3 | 2.05951 |
| NOC4L | nucleolar complex associated 4 homolog (S. cerevisiae) | 2.03555 |
| SLC25A14 | solute carrier family 25 (mitochondrial carrier, brain), member 14 | 2.03539 |
| ALG9 | ALG9, alpha-1,2-mannosyltransferase | 2.02417 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 2.01794 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 2.00636 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -6.73102 |
| ZNF586 | zinc finger protein 586 | -5.74541 |
| CCNB1 | cyclin B1 | -5.70675 |
| ELAC2 | elaC ribonuclease Z 2 | -4.91471 |
| SLC35F2 | solute carrier family 35, member F2 | -4.82132 |
| CCDC86 | coiled-coil domain containing 86 | -4.15105 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -4.10468 |
| TSPAN4 | tetraspanin 4 | -3.97379 |
| FASTKD5 | FAST kinase domains 5 | -3.91266 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -3.83149 |
| CCNB2 | cyclin B2 | -3.18216 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -3.09906 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -3.06344 |
| TRIM9 | tripartite motif containing 9 | -3.02611 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -2.94686 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -2.89241 |
| FAAP24 | FA core complex associated protein 24 | -2.75408 |
| CDC25B | cell division cycle 25B | -2.70062 |
| SHC3 | SHC (Src homology 2 domain containing) transforming protein 3 | -2.59859 |
| RRAGC | Ras-related GTP binding C | -2.56668 |
| GEMIN6 | gem (nuclear organelle) associated protein 6 | -2.52646 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -2.48733 |
| CORT | cortistatin | -2.48083 |
| GNAS | GNAS complex locus | -2.46268 |
| MMP15 | matrix metallopeptidase 15 (membrane-inserted) | -2.44864 |
| SDHB | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | -2.43598 |
| MAFG | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G | -2.37455 |
| MEPE | matrix extracellular phosphoglycoprotein | -2.37238 |
| MYL9 | myosin, light chain 9, regulatory | -2.36165 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.35963 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.35864 |
| GSTT4 | glutathione S-transferase theta 4 | -2.3574 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -2.3412 |
| LOC124907782 | dual specificity protein phosphatase 22 | -2.33588 |
| MVP | major vault protein | -2.3185 |
| SNCB | synuclein, beta | -2.3114 |
| SHCBP1L | SHC SH2-domain binding protein 1-like | -2.29403 |
| PHF13 | PHD finger protein 13 | -2.29214 |
| MELK | maternal embryonic leucine zipper kinase | -2.28578 |
| ZNRF4 | zinc and ring finger 4 | -2.28427 |
| CPNE3 | copine III | -2.28354 |
| EXD3 | exonuclease 3'-5' domain containing 3 | -2.2527 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | -2.245 |
| TERT | telomerase reverse transcriptase | -2.23664 |
| NARS2 | asparaginyl-tRNA synthetase 2, mitochondrial (putative) | -2.2189 |
| GRIA3 | glutamate receptor, ionotropic, AMPA 3 | -2.21207 |
| SLC45A2 | solute carrier family 45, member 2 | -2.21089 |
| KNOP1 | lysine-rich nucleolar protein 1 | -2.20941 |
| MKRN3 | makorin ring finger protein 3 | -2.20265 |
| CCDC47 | coiled-coil domain containing 47 | -2.20179 |
| CYP2W1 | cytochrome P450, family 2, subfamily W, polypeptide 1 | -2.19836 |
| KIF25 | kinesin family member 25 | -2.18797 |
| TOLLIP | toll interacting protein | -2.18163 |
| CDC20 | cell division cycle 20 | -2.17738 |
| TFDP1 | transcription factor Dp-1 | -2.15529 |
| PES1 | pescadillo ribosomal biogenesis factor 1 | -2.15493 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -2.15444 |
| PATJ | PATJ crumbs cell polarity complex component | -2.1432 |
| TXNDC9 | thioredoxin domain containing 9 | -2.13909 |
| PGAM2 | phosphoglycerate mutase 2 (muscle) | -2.10294 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -2.09214 |
| HSPB3 | heat shock 27kDa protein 3 | -2.09107 |
| MAGEC2 | melanoma antigen family C2 | -2.07671 |
| ZNF500 | zinc finger protein 500 | -2.06276 |
| CCT8L2 | chaperonin containing TCP1, subunit 8 (theta)-like 2 | -2.05704 |
| MSH6 | mutS homolog 6 | -2.05515 |
| TNFRSF8 | tumor necrosis factor receptor superfamily, member 8 | -2.05142 |
| SNAP29 | synaptosomal-associated protein, 29kDa | -2.04965 |
| ZNF667 | zinc finger protein 667 | -2.03982 |
| KRT3 | keratin 3, type II | -2.03421 |
| SAPCD1 | suppressor APC domain containing 1 | -2.02294 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.02184 |
| DDO | D-aspartate oxidase | -2.01654 |
| PUF60 | poly-U binding splicing factor 60KDa | -2.01191 |
| PHF7 | PHD finger protein 7 | -2.00385 |
| MYO9A | myosin IXA | -2.00335 |
