CRCGN014_HEPG2_3H:K24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN014_HEPG2_3H:K24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 6.60022
CYCS cytochrome c, somatic 4.50776
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.83471
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.75873
MAMLD1 mastermind-like domain containing 1 3.30486
RPL39L ribosomal protein L39-like 3.25737
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.15907
ADRB2 adrenoceptor beta 2, surface 3.0971
LPAR2 lysophosphatidic acid receptor 2 3.04224
SKIC8 SKI8 subunit of superkiller complex 2.95166
UBQLN2 ubiquilin 2 2.94182
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.91719
CHN1 chimerin 1 2.87947
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.81332
STIMATE STIM activating enhancer 2.7203
COPS7A COP9 signalosome subunit 7A 2.58068
MAP7 microtubule-associated protein 7 2.47262
CEMIP2 cell migration inducing hyaluronidase 2 2.42824
SFTPB surfactant protein B 2.36346
CNPY3 canopy FGF signaling regulator 3 2.31494
NENF neudesin neurotrophic factor 2.28422
ZNF589 zinc finger protein 589 2.26963
C5 complement component 5 2.23378
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.05803

decreased expression

Symbol Name Standardized Value
PLK1 polo-like kinase 1 -7.08883
CCNB2 cyclin B2 -6.72546
TLR4 toll-like receptor 4 -5.24719
TLCD3A TLC domain containing 3A -4.13414
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.52273
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.33195
BPHL biphenyl hydrolase-like (serine hydrolase) -3.31293
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.22227
MRPS2 mitochondrial ribosomal protein S2 -3.19293
CDC20 cell division cycle 20 -3.04721
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.86984
PCNA proliferating cell nuclear antigen -2.81656
EIF5 eukaryotic translation initiation factor 5 -2.73237
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.61347
LDHD lactate dehydrogenase D -2.55508
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.13516
CDT1 chromatin licensing and DNA replication factor 1 -2.09746
CDC25B cell division cycle 25B -2.07442
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.04885
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.00828