CRCGN014_HEPG2_3H:L01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-chloroacetophenone 40.4 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

297 genes differentially expressed following the CRCGN014_HEPG2_3H:L01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PMM2 phosphomannomutase 2 6.16162
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.31547
USP6NL USP6 N-terminal like 5.28567
MEST mesoderm specific transcript 5.2478
CREB1 cAMP responsive element binding protein 1 4.58298
TXNRD1 thioredoxin reductase 1 4.4755
PPARG peroxisome proliferator-activated receptor gamma 4.40919
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.32665
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.31668
PTK2 protein tyrosine kinase 2 4.19644
ZNF589 zinc finger protein 589 4.15847
SHB Src homology 2 domain containing adaptor protein B 3.67356
EPHA3 EPH receptor A3 3.62471
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.55776
ABHD4 abhydrolase domain containing 4 3.50998
SYNGAP1 synaptic Ras GTPase activating protein 1 3.4282
CORO1A coronin, actin binding protein, 1A 3.37207
NUP133 nucleoporin 133kDa 3.36924
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.36419
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 3.35612
TIAM1 T-cell lymphoma invasion and metastasis 1 3.35441
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.21913
MMP2 matrix metallopeptidase 2 3.19555
GNAT3 guanine nucleotide binding protein, alpha transducing 3 3.11489
BAD BCL2-associated agonist of cell death 3.07019
FCHO1 FCH domain only 1 3.05064
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.99573
SFTPB surfactant protein B 2.99104
HMOX1 heme oxygenase 1 2.96092
DIPK1A divergent protein kinase domain 1A 2.941
NIT1 nitrilase 1 2.92302
JADE2 jade family PHD finger 2 2.90995
NTN1 netrin 1 2.86134
ZNF154 zinc finger protein 154 2.78676
EGF epidermal growth factor 2.75871
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.75862
STIP1 stress-induced phosphoprotein 1 2.75411
SSX1 synovial sarcoma, X breakpoint 1 2.74547
ZIC3 Zic family member 3 2.71441
EPHA5 EPH receptor A5 2.68776
TLR8 toll-like receptor 8 2.6823
IFNAR1 interferon (alpha, beta and omega) receptor 1 2.68118
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.63388
AMIGO2 adhesion molecule with Ig-like domain 2 2.63158
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 2.61666
ANKRD10 ankyrin repeat domain 10 2.61524
CTNNBIP1 catenin, beta interacting protein 1 2.60784
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.56963
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.56638
TRIB3 tribbles pseudokinase 3 2.55716
CRYBA1 crystallin, beta A1 2.54595
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.53615
TLX3 T-cell leukemia homeobox 3 2.50334
LOC100996750 keratin-associated protein 4-7 2.50073
TGFB2 transforming growth factor, beta 2 2.49891
GJA9 gap junction protein, alpha 9, 59kDa 2.48142
PTPRJ protein tyrosine phosphatase, receptor type, J 2.47723
GPR65 G protein-coupled receptor 65 2.47163
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.46716
GLRA1 glycine receptor, alpha 1 2.46313
NT5DC2 5'-nucleotidase domain containing 2 2.45094
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.44694
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.43373
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2.43256
TDRKH tudor and KH domain containing 2.41672
CNTNAP2 contactin associated protein-like 2 2.40336
IL2RB interleukin 2 receptor, beta 2.40302
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.40208
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.40062
TAS2R9 taste receptor, type 2, member 9 2.39737
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.39698
MC3R melanocortin 3 receptor 2.39457
ZNF282 zinc finger protein 282 2.38021
XDH xanthine dehydrogenase 2.37759
GPR18 G protein-coupled receptor 18 2.3757
CAPN11 calpain 11 2.37458
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 2.37318
HOXB8 homeobox B8 2.37279
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 2.37208
KCNK13 potassium channel, two pore domain subfamily K, member 13 2.3664
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.36114
ZNG1A Zn regulated GTPase metalloprotein activator 1A 2.35299
LCOR ligand dependent nuclear receptor corepressor 2.34565
GIPR gastric inhibitory polypeptide receptor 2.3439
PTTG2 pituitary tumor-transforming 2 2.34357
WNT3 wingless-type MMTV integration site family, member 3 2.32933
KRTAP9-9 keratin associated protein 9-9 2.3219
MCHR1 melanin-concentrating hormone receptor 1 2.31801
POM121L2 POM121 transmembrane nucleoporin-like 2 2.31449
H2BC17 H2B clustered histone 17 2.31218
ZNF407 zinc finger protein 407 2.31097
LINC02854 long intergenic non-protein coding RNA 2854 2.30921
FOXB1 forkhead box B1 2.30625
ACR acrosin 2.28841
TMC5 transmembrane channel-like 5 2.2841
TLK2 tousled-like kinase 2 2.27785
ZNF34 zinc finger protein 34 2.27314
IL10 interleukin 10 2.27138
OR1A2 olfactory receptor, family 1, subfamily A, member 2 2.2669
ATP11B ATPase, class VI, type 11B 2.26042
HCRTR1 hypocretin (orexin) receptor 1 2.26003
ZNF585B zinc finger protein 585B 2.25808
PPP1R17 protein phosphatase 1, regulatory subunit 17 2.25537
PRDM13 PR domain containing 13 2.25505
SSX4B synovial sarcoma, X breakpoint 4B 2.25425
XCR1 chemokine (C motif) receptor 1 2.24173
TRPC5 transient receptor potential cation channel, subfamily C, member 5 2.24034
PITPNM3 PITPNM family member 3 2.23385
CIAO3 cytosolic iron-sulfur assembly component 3 2.23362
RAB3B RAB3B, member RAS oncogene family 2.23091
IMPG1 interphotoreceptor matrix proteoglycan 1 2.22963
MAGEC3 melanoma antigen family C3 2.22877
TESK1 testis-specific kinase 1 2.22724
NPDC1 neural proliferation, differentiation and control, 1 2.22057
PSKH1 protein serine kinase H1 2.22045
ACOXL acyl-CoA oxidase-like 2.2199
CCDC82 coiled-coil domain containing 82 2.21982
CABP2 calcium binding protein 2 2.21898
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.21611
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2.213
IL1A interleukin 1, alpha 2.21159
ICE1 interactor of little elongation complex ELL subunit 1 2.20855
TENT4A terminal nucleotidyltransferase 4A 2.20603
MLNR motilin receptor 2.20252
CDK3 cyclin-dependent kinase 3 2.20207
EIF2D eukaryotic translation initiation factor 2D 2.1986
FGF16 fibroblast growth factor 16 2.19333
HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 2.18616
CASS4 Cas scaffolding protein family member 4 2.1811
TTC21B tetratricopeptide repeat domain 21B 2.1808
LCN2 lipocalin 2 2.17424
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 2.16651
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.16412
RXFP3 relaxin/insulin-like family peptide receptor 3 2.16066
SLFN12 schlafen family member 12 2.15532
PRR15L proline rich 15-like 2.15493
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.1518
USP53 ubiquitin specific peptidase 53 2.14564
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 2.14325
GCM1 glial cells missing homolog 1 (Drosophila) 2.14311
OR7A10 olfactory receptor, family 7, subfamily A, member 10 2.14291
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.1417
ANTXR1 anthrax toxin receptor 1 2.13403
TRPC4 transient receptor potential cation channel, subfamily C, member 4 2.13322
TLR4 toll-like receptor 4 2.1328
RTL8C retrotransposon Gag like 8C 2.13248
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 2.13068
CLEC10A C-type lectin domain family 10, member A 2.12673
GJA5 gap junction protein, alpha 5, 40kDa 2.12414
PLA2R1 phospholipase A2 receptor 1, 180kDa 2.11722
PRKG2 protein kinase, cGMP-dependent, type II 2.11678
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 2.11489
CUL1 cullin 1 2.11462
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 2.11439
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) 2.1103
SOX14 SRY (sex determining region Y)-box 14 2.11025
SRY sex determining region Y 2.10931
TEF thyrotrophic embryonic factor 2.10782
CD86 CD86 molecule 2.10381
ZNF202 zinc finger protein 202 2.10357
CD1D CD1d molecule 2.10163
SCRT1 scratch family zinc finger 1 2.10145
FN3K fructosamine 3 kinase 2.10046
PRKCE protein kinase C, epsilon 2.09959
WWC3 WWC family member 3 2.09783
IL26 interleukin 26 2.09588
H2BC21 H2B clustered histone 21 2.09186
USPL1 ubiquitin specific peptidase like 1 2.0911
FZD1 frizzled class receptor 1 2.0886
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2.08613
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 2.08309
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 2.07922
PACC1 proton activated chloride channel 1 2.07758
PSG3 pregnancy specific beta-1-glycoprotein 3 2.07486
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 2.07133
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 2.0703
FOXE3 forkhead box E3 2.06809
KIFC3 kinesin family member C3 2.06775
KAT2A K(lysine) acetyltransferase 2A 2.06466
RAB35 RAB35, member RAS oncogene family 2.06307
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.05875
GSC2 goosecoid homeobox 2 2.05617
BPY2B basic charge, Y-linked, 2B 2.05353
UBASH3A ubiquitin associated and SH3 domain containing A 2.05347
PBOV1 prostate and breast cancer overexpressed 1 2.04201
IFNA8 interferon, alpha 8 2.04088
ZNF674 zinc finger protein 674 2.04015
AKAP17A A kinase (PRKA) anchor protein 17A 2.0338
RASA2 RAS p21 protein activator 2 2.03279
NABP1 nucleic acid binding protein 1 2.02852
CLEC2D C-type lectin domain family 2, member D 2.02797
SAA2 serum amyloid A2 2.0274
GPR173 G protein-coupled receptor 173 2.02718
ZNF780B zinc finger protein 780B 2.02361
PLA2G2F phospholipase A2, group IIF 2.02296
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 2.02197
SSX2 synovial sarcoma, X breakpoint 2 2.0217
DIAPH3 diaphanous-related formin 3 2.01888
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 2.01837
GPR68 G protein-coupled receptor 68 2.01768
IL11RA interleukin 11 receptor, alpha 2.01752
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.01585
TLL1 tolloid-like 1 2.01325
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 2.01057
NEUROD4 neuronal differentiation 4 2.01029
CLCN4 chloride channel, voltage-sensitive 4 2.00953
PSD4 pleckstrin and Sec7 domain containing 4 2.00681
MARK2 MAP/microtubule affinity-regulating kinase 2 2.00552
SCN9A sodium channel, voltage gated, type IX alpha subunit 2.00003

decreased expression

Symbol Name Standardized Value
BPHL biphenyl hydrolase-like (serine hydrolase) -6.5452
ADI1 acireductone dioxygenase 1 -6.39376
SCAND1 SCAN domain containing 1 -5.35446
GLOD4 glyoxalase domain containing 4 -5.25098
C2CD5 C2 calcium-dependent domain containing 5 -5.10244
CCNH cyclin H -4.86035
SPAG4 sperm associated antigen 4 -4.51827
CAB39 calcium binding protein 39 -4.44046
GRWD1 glutamate-rich WD repeat containing 1 -4.26911
NGRN neugrin, neurite outgrowth associated -4.17301
LDHD lactate dehydrogenase D -4.16161
PCNA proliferating cell nuclear antigen -4.0776
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.86279
MRPS2 mitochondrial ribosomal protein S2 -3.81741
GNAS GNAS complex locus -3.71054
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.67044
APOE apolipoprotein E -3.54212
ETFB electron-transfer-flavoprotein, beta polypeptide -3.54173
ACAA1 acetyl-CoA acyltransferase 1 -3.48357
PTPRK protein tyrosine phosphatase, receptor type, K -3.42527
HEATR1 HEAT repeat containing 1 -3.30183
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.26413
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -3.19311
FOS FBJ murine osteosarcoma viral oncogene homolog -3.16418
DCK deoxycytidine kinase -3.1194
ICAM3 intercellular adhesion molecule 3 -2.92186
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.92061
TBC1D31 TBC1 domain family, member 31 -2.91364
TCEAL4 transcription elongation factor A (SII)-like 4 -2.89887
ENOPH1 enolase-phosphatase 1 -2.87274
NUP93 nucleoporin 93kDa -2.82604
VAT1 vesicle amine transport 1 -2.78505
BRCA1 breast cancer 1, early onset -2.76406
THAP11 THAP domain containing 11 -2.74385
ARHGAP1 Rho GTPase activating protein 1 -2.74124
SLC35F2 solute carrier family 35, member F2 -2.7271
MPC1 mitochondrial pyruvate carrier 1 -2.66598
CDK4 cyclin-dependent kinase 4 -2.65449
TCTN1 tectonic family member 1 -2.65158
CUEDC2 CUE domain containing 2 -2.64472
DDB2 damage-specific DNA binding protein 2, 48kDa -2.62757
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.61632
CSK c-src tyrosine kinase -2.61177
OXA1L oxidase (cytochrome c) assembly 1-like -2.59116
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.57282
CRELD2 cysteine-rich with EGF-like domains 2 -2.55682
MOK MOK protein kinase -2.54225
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.51734
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.51436
NOLC1 nucleolar and coiled-body phosphoprotein 1 -2.48076
RWDD2B RWD domain containing 2B -2.46433
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.45988
BTBD1 BTB (POZ) domain containing 1 -2.45174
EAPP E2F-associated phosphoprotein -2.44855
RPIA ribose 5-phosphate isomerase A -2.42586
TM9SF2 transmembrane 9 superfamily member 2 -2.40565
CRYZ crystallin, zeta (quinone reductase) -2.39102
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.38824
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.37797
ETNK1 ethanolamine kinase 1 -2.35102
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.34071
DYNLT3 dynein, light chain, Tctex-type 3 -2.33685
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 -2.3293
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.30808
CDC20 cell division cycle 20 -2.28983
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -2.27927
PEX11A peroxisomal biogenesis factor 11 alpha -2.26486
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.22868
PCCB propionyl CoA carboxylase, beta polypeptide -2.21852
DAPL1 death associated protein-like 1 -2.18999
RPL26L1 ribosomal protein L26-like 1 -2.18943
LGMN legumain -2.17851
MRPS16 mitochondrial ribosomal protein S16 -2.1748
SNF8 SNF8, ESCRT-II complex subunit -2.16439
CUTC cutC copper transporter -2.16042
LAGE3 L antigen family, member 3 -2.13708
CIB1 calcium and integrin binding 1 (calmyrin) -2.13687
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.11539
SNRPG small nuclear ribonucleoprotein polypeptide G -2.1124
HMGA2 high mobility group AT-hook 2 -2.09655
RBKS ribokinase -2.08621
PECR peroxisomal trans-2-enoyl-CoA reductase -2.07715
ANXA7 annexin A7 -2.06106
NPTX2 neuronal pentraxin II -2.0515
TOP2B topoisomerase (DNA) II beta 180kDa -2.05141
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -2.01149
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.01131
HDAC2 histone deacetylase 2 -2.00516