CRCGN014_HEPG2_3H:L02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diphenhydramine 40.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

77 genes differentially expressed following the CRCGN014_HEPG2_3H:L02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 7.82496
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 6.62024
PMM2 phosphomannomutase 2 5.25841
PNKP polynucleotide kinase 3'-phosphatase 5.10222
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.08477
MSRA methionine sulfoxide reductase A 5.03389
ABHD4 abhydrolase domain containing 4 4.85701
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 4.82419
JADE2 jade family PHD finger 2 4.73814
AMDHD2 amidohydrolase domain containing 2 4.52076
CXCL2 chemokine (C-X-C motif) ligand 2 4.50394
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.12427
CHN1 chimerin 1 3.98135
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 3.97585
STXBP2 syntaxin binding protein 2 3.6841
CYCS cytochrome c, somatic 3.26216
NOSIP nitric oxide synthase interacting protein 3.25291
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.1978
USP6NL USP6 N-terminal like 3.09749
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.08362
SFTPB surfactant protein B 3.04265
HYOU1 hypoxia up-regulated 1 2.91787
GPER1 G protein-coupled estrogen receptor 1 2.73714
KIF14 kinesin family member 14 2.70642
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.70541
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.53173
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.51606
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.42935
CSK c-src tyrosine kinase 2.33895
GPATCH8 G patch domain containing 8 2.32915
LRP2 low density lipoprotein receptor-related protein 2 2.25805
CHMP7 charged multivesicular body protein 7 2.17227
ENY2 enhancer of yellow 2 homolog (Drosophila) 2.16753
TENT4A terminal nucleotidyltransferase 4A 2.15828
PRR15L proline rich 15-like 2.15314
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 2.14967
GATA2 GATA binding protein 2 2.10196
CEMIP2 cell migration inducing hyaluronidase 2 2.09526
ZC3H3 zinc finger CCCH-type containing 3 2.07626
ATP11B ATPase, class VI, type 11B 2.03884
ANO1 anoctamin 1, calcium activated chloride channel 2.02876
ZHX2 zinc fingers and homeoboxes 2 2.01402

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -9.47434
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.86416
DNM1L dynamin 1-like -4.67196
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.65807
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.63992
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.56215
PCNA proliferating cell nuclear antigen -4.26382
FAIM Fas apoptotic inhibitory molecule -4.20946
PSIP1 PC4 and SFRS1 interacting protein 1 -3.87601
CD58 CD58 molecule -3.83841
TLCD3A TLC domain containing 3A -3.67633
ZNF586 zinc finger protein 586 -3.54149
SPAG4 sperm associated antigen 4 -3.51294
PECR peroxisomal trans-2-enoyl-CoA reductase -3.01629
BIRC5 baculoviral IAP repeat containing 5 -2.9543
GRWD1 glutamate-rich WD repeat containing 1 -2.72493
ACAA1 acetyl-CoA acyltransferase 1 -2.71067
AOPEP aminopeptidase O (putative) -2.60801
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.57214
TM9SF2 transmembrane 9 superfamily member 2 -2.5469
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.5238
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.38935
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.3776
SCCPDH saccharopine dehydrogenase (putative) -2.14205
MED31 mediator complex subunit 31 -2.12854
REEP5 receptor accessory protein 5 -2.10749
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 -2.09334
ADGRE5 adhesion G protein-coupled receptor E5 -2.08758
CD207 CD207 molecule, langerin -2.06573
CHD9NB CHD9 neighbor -2.0617
STAT5A signal transducer and activator of transcription 5A -2.05606
ETFB electron-transfer-flavoprotein, beta polypeptide -2.05092
KATNB1 katanin p80 (WD repeat containing) subunit B 1 -2.04413
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 -2.00559
HMOX1 heme oxygenase 1 -2.0034