CRCGN014_HEPG2_3H:L05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description vorinostat 20.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

269 genes differentially expressed following the CRCGN014_HEPG2_3H:L05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PRKCD protein kinase C, delta 7.76833
FOXO4 forkhead box O4 7.17254
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 6.8727
TIMP2 TIMP metallopeptidase inhibitor 2 6.4358
HSPA1A heat shock 70kDa protein 1A 6.2371
ALDOC aldolase C, fructose-bisphosphate 5.94596
PLA2G15 phospholipase A2, group XV 5.88064
NOTCH1 notch 1 5.77072
ALAS1 5'-aminolevulinate synthase 1 5.64548
STX1A syntaxin 1A (brain) 5.6183
CCND3 cyclin D3 5.54445
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 5.23674
PLS1 plastin 1 4.98931
CGRRF1 cell growth regulator with ring finger domain 1 4.93665
CORO1A coronin, actin binding protein, 1A 4.9165
PTPN1 protein tyrosine phosphatase, non-receptor type 1 4.69673
GPATCH8 G patch domain containing 8 4.62456
STXBP1 syntaxin binding protein 1 4.60337
TBPL1 TBP-like 1 4.50929
TBC1D10C TBC1 domain family, member 10C 4.46625
MCOLN1 mucolipin 1 4.45881
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 4.36031
CDK7 cyclin-dependent kinase 7 4.19364
BLCAP bladder cancer associated protein 3.99103
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 3.80156
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.78082
TRAK2 trafficking protein, kinesin binding 2 3.73437
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 3.73413
BAG3 BCL2-associated athanogene 3 3.54954
ICAM1 intercellular adhesion molecule 1 3.47631
UBE2A ubiquitin-conjugating enzyme E2A 3.43059
UBE2L6 ubiquitin-conjugating enzyme E2L 6 3.41745
GLRX glutaredoxin (thioltransferase) 3.27244
PNKP polynucleotide kinase 3'-phosphatase 3.18957
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.10022
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 3.09189
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.079
GPR162 G protein-coupled receptor 162 3.02219
MELK maternal embryonic leucine zipper kinase 3.01367
SNAP25 synaptosomal-associated protein, 25kDa 3.01124
CYTH1 cytohesin 1 3.00497
KIF14 kinesin family member 14 3.00496
RMC1 regulator of MON1-CCZ1 2.94253
KIN Kin17 DNA and RNA binding protein 2.89471
SCPEP1 serine carboxypeptidase 1 2.83153
NUP133 nucleoporin 133kDa 2.80734
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.80183
WDR37 WD repeat domain 37 2.80087
MVP major vault protein 2.77107
NCOA3 nuclear receptor coactivator 3 2.74729
HMG20B high mobility group 20B 2.71154
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 2.66546
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.65608
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.61493
LSR lipolysis stimulated lipoprotein receptor 2.60346
DYNLT3 dynein, light chain, Tctex-type 3 2.59697
TCEA2 transcription elongation factor A (SII), 2 2.56265
LPAR2 lysophosphatidic acid receptor 2 2.55055
MAP7 microtubule-associated protein 7 2.54418
NT5C2 5'-nucleotidase, cytosolic II 2.53276
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.51458
ZDHHC6 zinc finger, DHHC-type containing 6 2.5094
FZD7 frizzled class receptor 7 2.48988
PRPF38B pre-mRNA processing factor 38B 2.48728
DUSP14 dual specificity phosphatase 14 2.47548
ARFIP2 ADP-ribosylation factor interacting protein 2 2.47405
PORCN porcupine homolog (Drosophila) 2.47012
CFAP20 cilia and flagella associated protein 20 2.45926
WDR19 WD repeat domain 19 2.45623
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.44954
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.44678
RND1 Rho family GTPase 1 2.40912
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 2.35524
MDH1 malate dehydrogenase 1, NAD (soluble) 2.34813
TESK2 testis-specific kinase 2 2.34755
PEX11B peroxisomal biogenesis factor 11 beta 2.34105
BMPR1A bone morphogenetic protein receptor, type IA 2.32519
ATG2A autophagy related 2A 2.31896
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 2.31384
TREM1 triggering receptor expressed on myeloid cells 1 2.31211
IFT52 intraflagellar transport 52 2.30713
SLC25A44 solute carrier family 25, member 44 2.2988
MAP3K3 mitogen-activated protein kinase kinase kinase 3 2.29234
NAP1L3 nucleosome assembly protein 1-like 3 2.28632
AAMDC adipogenesis associated, Mth938 domain containing 2.28389
TSC22D4 TSC22 domain family, member 4 2.27866
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.27215
FCHO1 FCH domain only 1 2.24682
IDI1 isopentenyl-diphosphate delta isomerase 1 2.24305
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 2.2382
SHFL shiftless antiviral inhibitor of ribosomal frameshifting 2.22073
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.22026
ADIPOR1 adiponectin receptor 1 2.21262
DPF1 D4, zinc and double PHD fingers family 1 2.20784
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 2.19727
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 2.19642
TM7SF2 transmembrane 7 superfamily member 2 2.18844
INPPL1 inositol polyphosphate phosphatase-like 1 2.18778
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.17592
HMOX1 heme oxygenase 1 2.16534
SOBP sine oculis binding protein homolog (Drosophila) 2.15682
PIAS3 protein inhibitor of activated STAT, 3 2.15173
TMEM231 transmembrane protein 231 2.15155
HSPA1B heat shock 70kDa protein 1B 2.14664
LOC124900388 uncharacterized LOC124900388 2.14263
DZANK1 double zinc ribbon and ankyrin repeat domains 1 2.13815
TRPS1 trichorhinophalangeal syndrome I 2.13677
BIN3 bridging integrator 3 2.13411
RUBCN rubicon autophagy regulator 2.13068
LONP2 lon peptidase 2, peroxisomal 2.12205
EFNA3 ephrin-A3 2.12041
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.11749
SNAI1 snail family zinc finger 1 2.0853
KIFC3 kinesin family member C3 2.07615
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.07232
RRAGC Ras-related GTP binding C 2.07077
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 2.06931
CALM1 calmodulin 1 (phosphorylase kinase, delta) 2.06882
PLCH2 phospholipase C, eta 2 2.06564
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa 2.0656
SUOX sulfite oxidase 2.06222
SFTPB surfactant protein B 2.05426
DYNC2I1 dynein 2 intermediate chain 1 2.04021
EPHB3 EPH receptor B3 2.0307
HAND2 heart and neural crest derivatives expressed 2 2.02273
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 2.0219
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.01628
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 2.01573
UNC93B1 unc-93 homolog B1 (C. elegans) 2.00896
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 2.00622

decreased expression

Symbol Name Standardized Value
ISOC1 isochorismatase domain containing 1 -10.0
CD320 CD320 molecule -10.0
CCNB2 cyclin B2 -9.73359
KEAP1 kelch-like ECH-associated protein 1 -8.52676
TRIB3 tribbles pseudokinase 3 -7.62804
MYC v-myc avian myelocytomatosis viral oncogene homolog -6.6644
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -5.92735
TCERG1 transcription elongation regulator 1 -5.44698
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.3884
SPAG4 sperm associated antigen 4 -5.26332
TLCD3A TLC domain containing 3A -5.17692
GTPBP8 GTP-binding protein 8 (putative) -5.07792
CCDC86 coiled-coil domain containing 86 -4.75753
GRWD1 glutamate-rich WD repeat containing 1 -4.63884
SLC35F2 solute carrier family 35, member F2 -4.50361
RPP38 ribonuclease P/MRP 38kDa subunit -4.38699
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.10886
DSG2 desmoglein 2 -3.88529
FOSL1 FOS-like antigen 1 -3.82263
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.75557
DCK deoxycytidine kinase -3.58104
C2CD5 C2 calcium-dependent domain containing 5 -3.57838
BIRC2 baculoviral IAP repeat containing 2 -3.45364
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.3461
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.29391
TRIM13 tripartite motif containing 13 -3.20658
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -3.17911
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.1716
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.10472
MRM3 mitochondrial rRNA methyltransferase 3 -3.03458
EXOSC8 exosome component 8 -3.0257
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.00825
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.93825
TEAD4 TEA domain family member 4 -2.90194
PMM2 phosphomannomutase 2 -2.86242
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -2.84358
TIMCC TIM double twin CX3C motif chaperone -2.81886
TUBGCP5 tubulin, gamma complex associated protein 5 -2.78788
AKAP8 A kinase (PRKA) anchor protein 8 -2.72219
LDHD lactate dehydrogenase D -2.71969
NUP54 nucleoporin 54kDa -2.71968
RAB11FIP2 RAB11 family interacting protein 2 (class I) -2.69897
MAPK13 mitogen-activated protein kinase 13 -2.69471
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.68831
USP22 ubiquitin specific peptidase 22 -2.67854
NFE2L2 nuclear factor, erythroid 2-like 2 -2.6705
BYSL bystin-like -2.65022
NUP62 nucleoporin 62kDa -2.6119
CD58 CD58 molecule -2.597
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -2.57721
LRRC41 leucine rich repeat containing 41 -2.56002
THAP7 THAP domain containing 7 -2.55657
PARP2 poly (ADP-ribose) polymerase 2 -2.55077
ELSPBP1 epididymal sperm binding protein 1 -2.54468
CTCF CCCTC-binding factor (zinc finger protein) -2.54316
TCEAL4 transcription elongation factor A (SII)-like 4 -2.53835
FOXM1 forkhead box M1 -2.52143
OIP5 Opa interacting protein 5 -2.51611
CYREN cell cycle regulator of NHEJ -2.50612
FAM174C family with sequence similarity 174 member C -2.49996
STARD13 StAR-related lipid transfer (START) domain containing 13 -2.46693
ZNF146 zinc finger protein 146 -2.45539
YJU2 YJU2 splicing factor homolog -2.44562
IBSP integrin-binding sialoprotein -2.38841
IGHMBP2 immunoglobulin mu binding protein 2 -2.35921
NLE1 notchless homolog 1 (Drosophila) -2.33928
PAK1IP1 PAK1 interacting protein 1 -2.32631
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -2.32599
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor -2.31034
ALG12 ALG12, alpha-1,6-mannosyltransferase -2.30399
ANKRD40 ankyrin repeat domain 40 -2.27738
YEATS4 YEATS domain containing 4 -2.26191
XPOT exportin, tRNA -2.24458
DERL1 derlin 1 -2.23429
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.23318
TXLNA taxilin alpha -2.23053
SMNDC1 survival motor neuron domain containing 1 -2.22676
ABHD14A abhydrolase domain containing 14A -2.22411
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.22347
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -2.21689
PRPF4 pre-mRNA processing factor 4 -2.21196
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit -2.21033
UBQLN2 ubiquilin 2 -2.20539
CPAP centrosome assembly and centriole elongation protein -2.20286
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -2.19683
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.18998
NUSAP1 nucleolar and spindle associated protein 1 -2.18946
LCMT2 leucine carboxyl methyltransferase 2 -2.18645
WDR43 WD repeat domain 43 -2.18503
SPAG7 sperm associated antigen 7 -2.18323
MRPL57 mitochondrial ribosomal protein L57 -2.17651
CCNA2 cyclin A2 -2.17127
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -2.16974
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.15439
SLC25A46 solute carrier family 25, member 46 -2.15141
LARS1 leucyl-tRNA synthetase 1 -2.15042
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -2.1477
CCDC59 coiled-coil domain containing 59 -2.14451
MSH6 mutS homolog 6 -2.14217
IL4R interleukin 4 receptor -2.13898
CDCA3 cell division cycle associated 3 -2.13612
UBIAD1 UbiA prenyltransferase domain containing 1 -2.13404
MRPL11 mitochondrial ribosomal protein L11 -2.12798
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.12519
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) -2.12471
UFM1 ubiquitin-fold modifier 1 -2.11631
CLDND1 claudin domain containing 1 -2.11502
RAB43 RAB43, member RAS oncogene family -2.11105
TRMO tRNA methyltransferase O -2.10776
TIPIN TIMELESS interacting protein -2.10772
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -2.10342
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.10234
ANO3 anoctamin 3 -2.10103
ICE2 interactor of little elongation complex ELL subunit 2 -2.10087
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -2.0972
BRCA1 breast cancer 1, early onset -2.09491
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -2.09224
IARS1 isoleucyl-tRNA synthetase 1 -2.07916
PLK1 polo-like kinase 1 -2.06201
ACOD1 aconitate decarboxylase 1 -2.06103
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -2.05241
DEAF1 DEAF1 transcription factor -2.05068
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -2.03998
GEMIN4 gem (nuclear organelle) associated protein 4 -2.03847
LRRC47 leucine rich repeat containing 47 -2.03846
PAGR1 PAXIP1 associated glutamate-rich protein 1 -2.037
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -2.03648
SIAH1 siah E3 ubiquitin protein ligase 1 -2.02982
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 -2.02872
NOL11 nucleolar protein 11 -2.02669
PDZD8 PDZ domain containing 8 -2.02599
PES1 pescadillo ribosomal biogenesis factor 1 -2.01727
PRDX4 peroxiredoxin 4 -2.01352
CCDC51 coiled-coil domain containing 51 -2.01284
COA3 cytochrome c oxidase assembly factor 3 -2.01013
KITLG KIT ligand -2.00679
ZHX2 zinc fingers and homeoboxes 2 -2.00583
TMEM39B transmembrane protein 39B -2.00318
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -2.00071