CRCGN014_HEPG2_3H:L07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tryptophan 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

58 genes differentially expressed following the CRCGN014_HEPG2_3H:L07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 7.61458
CYCS cytochrome c, somatic 5.13094
GPATCH8 G patch domain containing 8 4.04506
MINDY1 MINDY lysine 48 deubiquitinase 1 3.48742
MAMLD1 mastermind-like domain containing 1 3.47219
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.28222
E2F2 E2F transcription factor 2 3.23229
PPARG peroxisome proliferator-activated receptor gamma 3.19038
MYLK myosin light chain kinase 3.06494
RAP1GAP RAP1 GTPase activating protein 2.81234
DIPK1A divergent protein kinase domain 1A 2.78576
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.7144
CCDC86 coiled-coil domain containing 86 2.69854
PLSCR3 phospholipid scramblase 3 2.68579
PTK2 protein tyrosine kinase 2 2.6683
CHN1 chimerin 1 2.62012
TESK1 testis-specific kinase 1 2.51027
DYNLT3 dynein, light chain, Tctex-type 3 2.46201
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.4354
TIAM1 T-cell lymphoma invasion and metastasis 1 2.43151
TGM4 transglutaminase 4 2.35509
EPN2 epsin 2 2.33925
COPS7A COP9 signalosome subunit 7A 2.3145
NDOR1 NADPH dependent diflavin oxidoreductase 1 2.311
GPER1 G protein-coupled estrogen receptor 1 2.25484
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 2.23872
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 2.22084
GSTZ1 glutathione S-transferase zeta 1 2.18557
CDK19 cyclin-dependent kinase 19 2.15307
SORBS3 sorbin and SH3 domain containing 3 2.14538
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.12441
MROH7 maestro heat-like repeat family member 7 2.12043
ACTL7A actin-like 7A 2.08524
OXT oxytocin/neurophysin I prepropeptide 2.08455
CATSPERZ catsper channel auxiliary subunit zeta 2.0391
STIM1 stromal interaction molecule 1 2.03556
H2AP H2A.P histone 2.03285
TRIM66 tripartite motif containing 66 2.00642

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -8.81413
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.42067
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.29073
CHMP4B charged multivesicular body protein 4B -3.24818
LDHD lactate dehydrogenase D -3.24683
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.23611
GOLT1B golgi transport 1B -3.17801
CCNB2 cyclin B2 -3.07287
RAI14 retinoic acid induced 14 -2.89156
CSK c-src tyrosine kinase -2.64099
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.63327
CCNB1 cyclin B1 -2.57647
GNAS GNAS complex locus -2.48737
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.46078
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.21868
DERA deoxyribose-phosphate aldolase (putative) -2.18602
GRWD1 glutamate-rich WD repeat containing 1 -2.13959
ACAA1 acetyl-CoA acyltransferase 1 -2.02
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.01606
SMG5 SMG5 nonsense mediated mRNA decay factor -2.00246