CRCGN014_HEPG2_3H:L10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMBA 39.6 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

99 genes differentially expressed following the CRCGN014_HEPG2_3H:L10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 6.08056
PNKP polynucleotide kinase 3'-phosphatase 5.29903
C2CD2 C2 calcium-dependent domain containing 2 4.37974
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.23175
UBQLN2 ubiquilin 2 4.03811
AMDHD2 amidohydrolase domain containing 2 3.9639
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.8517
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.76473
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.74655
CNPY3 canopy FGF signaling regulator 3 3.68844
STXBP2 syntaxin binding protein 2 3.64258
CHMP6 charged multivesicular body protein 6 3.63313
ADRB2 adrenoceptor beta 2, surface 3.50437
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.47555
CYCS cytochrome c, somatic 3.40005
STIMATE STIM activating enhancer 3.35752
TIAM1 T-cell lymphoma invasion and metastasis 1 3.19638
CHN1 chimerin 1 2.85111
PLSCR3 phospholipid scramblase 3 2.71035
MCUR1 mitochondrial calcium uniporter regulator 1 2.6422
FPGS folylpolyglutamate synthase 2.62133
GPHRA golgi pH regulator A 2.57849
ODF2 outer dense fiber of sperm tails 2 2.48183
IER3 immediate early response 3 2.44523
FOSL1 FOS-like antigen 1 2.41253
ANKRD10 ankyrin repeat domain 10 2.40309
BZW2 basic leucine zipper and W2 domains 2 2.32246
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 2.28657
MPC2 mitochondrial pyruvate carrier 2 2.27799
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 2.24551
DIPK1A divergent protein kinase domain 1A 2.23021
KLHL21 kelch-like family member 21 2.21973
ERCC2 excision repair cross-complementation group 2 2.21771
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 2.15326
MAP9 microtubule-associated protein 9 2.14105
SKIC2 SKI2 subunit of superkiller complex 2.13827
TTI2 TELO2 interacting protein 2 2.13308
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.12958
FAM131B family with sequence similarity 131, member B 2.08792
PGAM4 phosphoglycerate mutase family member 4 2.07668
RANBP9 RAN binding protein 9 2.0762
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.0706
CEP57 centrosomal protein 57kDa 2.05103
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 2.02921
SQOR sulfide quinone oxidoreductase 2.02482
TPM3 tropomyosin 3 2.02469
ZNF195 zinc finger protein 195 2.02135
CERS2 ceramide synthase 2 2.0211
PLK3 polo-like kinase 3 2.02081
PLEKHO1 pleckstrin homology domain containing, family O member 1 2.0172
BMP4 bone morphogenetic protein 4 2.01668
RALGDS ral guanine nucleotide dissociation stimulator 2.01265
TUBB6 tubulin, beta 6 class V 2.01161
HCFC2 host cell factor C2 2.01092
DDIT4 DNA-damage-inducible transcript 4 2.0064
GPX7 glutathione peroxidase 7 2.00088

decreased expression

Symbol Name Standardized Value
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.94881
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -5.68729
ZMIZ1 zinc finger, MIZ-type containing 1 -5.3166
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.83822
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -4.758
CCNB2 cyclin B2 -4.48245
PSRC1 proline/serine-rich coiled-coil 1 -4.40528
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.38626
MAPK13 mitogen-activated protein kinase 13 -3.67917
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.65314
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.60248
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.57153
HSPB1 heat shock 27kDa protein 1 -3.25321
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.1797
WDR7 WD repeat domain 7 -2.86094
SNX11 sorting nexin 11 -2.78334
NAV2 neuron navigator 2 -2.74384
SPAG4 sperm associated antigen 4 -2.69173
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.62117
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -2.59773
GET1 guided entry of tail-anchored proteins factor 1 -2.58375
RASL12 RAS-like, family 12 -2.51953
DAAM1 dishevelled associated activator of morphogenesis 1 -2.47943
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -2.37028
OIP5 Opa interacting protein 5 -2.21701
CDCA8 cell division cycle associated 8 -2.21576
AVL9 AVL9 homolog (S. cerevisiase) -2.21478
OXA1L oxidase (cytochrome c) assembly 1-like -2.19914
SEC61G Sec61 gamma subunit -2.19721
NOD1 nucleotide-binding oligomerization domain containing 1 -2.18229
STIL SCL/TAL1 interrupting locus -2.1468
RSBN1 round spermatid basic protein 1 -2.14158
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.11252
FADS2 fatty acid desaturase 2 -2.08706
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -2.07894
GGCT gamma-glutamylcyclotransferase -2.07166
ATG4A autophagy related 4A, cysteine peptidase -2.05082
RPAP1 RNA polymerase II associated protein 1 -2.04389
WDR45B WD repeat domain 45B -2.03303
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.02239
ZHX2 zinc fingers and homeoboxes 2 -2.01384
NSF N-ethylmaleimide-sensitive factor -2.0129
TERF2 telomeric repeat binding factor 2 -2.01194