| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | safrole 40.2 um perturbation at 3 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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81 genes differentially expressed following the CRCGN014_HEPG2_3H:L11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ADGRE5 | adhesion G protein-coupled receptor E5 | 9.01887 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 8.77835 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 7.14646 |
| STIMATE | STIM activating enhancer | 6.72467 |
| KIF14 | kinesin family member 14 | 4.51802 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 4.38536 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 4.15241 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 4.14343 |
| UBQLN2 | ubiquilin 2 | 4.07047 |
| E2F2 | E2F transcription factor 2 | 3.84856 |
| CHMP6 | charged multivesicular body protein 6 | 3.41713 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 3.40597 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 3.27265 |
| GSTZ1 | glutathione S-transferase zeta 1 | 3.22013 |
| GATA3 | GATA binding protein 3 | 3.18942 |
| MAP7 | microtubule-associated protein 7 | 3.09701 |
| LOC122526780 | uncharacterized LOC122526780 | 2.94716 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.92734 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.84356 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | 2.83102 |
| TPD52L2 | tumor protein D52-like 2 | 2.60494 |
| TMEM131L | transmembrane 131 like | 2.40083 |
| EPHX3 | epoxide hydrolase 3 | 2.36878 |
| ALG6 | ALG6, alpha-1,3-glucosyltransferase | 2.32716 |
| GALNT15 | polypeptide N-acetylgalactosaminyltransferase 15 | 2.2696 |
| WDTC1 | WD and tetratricopeptide repeats 1 | 2.20689 |
| HPRT1 | hypoxanthine phosphoribosyltransferase 1 | 2.20388 |
| GID8 | GID complex subunit 8 | 2.18713 |
| FPGS | folylpolyglutamate synthase | 2.18492 |
| THG1L | tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) | 2.16468 |
| CHEK2 | checkpoint kinase 2 | 2.13243 |
| SGMS1 | sphingomyelin synthase 1 | 2.12583 |
| BCKDHA | branched chain keto acid dehydrogenase E1, alpha polypeptide | 2.10703 |
| AMFR | autocrine motility factor receptor, E3 ubiquitin protein ligase | 2.10423 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.10367 |
| MAGEF1 | melanoma antigen family F1 | 2.07279 |
| NOD2 | nucleotide-binding oligomerization domain containing 2 | 2.06047 |
| UBAC1 | UBA domain containing 1 | 2.03627 |
| CTSL | cathepsin L | 2.03134 |
| CAV3 | caveolin 3 | 2.0284 |
| GPATCH8 | G patch domain containing 8 | 2.00954 |
| SLC5A5 | solute carrier family 5 (sodium/iodide cotransporter), member 5 | 2.00938 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NT5DC2 | 5'-nucleotidase domain containing 2 | -4.78647 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.49029 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -4.44838 |
| LDHD | lactate dehydrogenase D | -4.3725 |
| CCNB2 | cyclin B2 | -4.35086 |
| GNAS | GNAS complex locus | -4.25588 |
| TSPAN4 | tetraspanin 4 | -4.21567 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -4.09346 |
| CCDC86 | coiled-coil domain containing 86 | -4.09012 |
| TLR4 | toll-like receptor 4 | -4.07065 |
| PLK1 | polo-like kinase 1 | -3.93647 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -3.93203 |
| DNM1L | dynamin 1-like | -3.79307 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -3.67254 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.39315 |
| RHEB | Ras homolog enriched in brain | -3.32848 |
| EIF5 | eukaryotic translation initiation factor 5 | -3.1355 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -2.85317 |
| TLCD3A | TLC domain containing 3A | -2.84151 |
| GNG4 | guanine nucleotide binding protein (G protein), gamma 4 | -2.66486 |
| NGRN | neugrin, neurite outgrowth associated | -2.63619 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | -2.51418 |
| NDUFB2 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa | -2.46215 |
| ARHGEF5 | Rho guanine nucleotide exchange factor (GEF) 5 | -2.39139 |
| CSNK1E | casein kinase 1, epsilon | -2.34884 |
| SIX6 | SIX homeobox 6 | -2.33661 |
| UBE2Q1 | ubiquitin-conjugating enzyme E2Q family member 1 | -2.29289 |
| SLC26A3 | solute carrier family 26 (anion exchanger), member 3 | -2.28276 |
| SLC35G2 | solute carrier family 35, member G2 | -2.27121 |
| DDX25 | DEAD (Asp-Glu-Ala-Asp) box helicase 25 | -2.21831 |
| HMOX1 | heme oxygenase 1 | -2.2158 |
| CLCA1 | chloride channel accessory 1 | -2.19788 |
| PPP1R2C | PPP1R2C family member C | -2.17972 |
| CDX2 | caudal type homeobox 2 | -2.17921 |
| FABP1 | fatty acid binding protein 1, liver | -2.15263 |
| BEX2 | brain expressed X-linked 2 | -2.12504 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.05891 |
| TNP1 | transition protein 1 (during histone to protamine replacement) | -2.0226 |
| PRDM8 | PR domain containing 8 | -2.00568 |
