CRCGN014_HEPG2_3H:L12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description emodin 20.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

137 genes differentially expressed following the CRCGN014_HEPG2_3H:L12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 9.92635
CHMP6 charged multivesicular body protein 6 8.39805
KCNK1 potassium channel, two pore domain subfamily K, member 1 7.5545
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.13495
NANOS3 nanos homolog 3 (Drosophila) 5.55265
EPHB2 EPH receptor B2 5.42352
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.1326
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.04625
PEX11A peroxisomal biogenesis factor 11 alpha 4.81363
STK10 serine/threonine kinase 10 4.49935
ADGRE5 adhesion G protein-coupled receptor E5 4.45195
MYLK myosin light chain kinase 4.37815
E2F2 E2F transcription factor 2 4.25385
SYCP2 synaptonemal complex protein 2 3.90913
PRKCH protein kinase C, eta 3.65383
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.4951
INSIG1 insulin induced gene 1 3.48577
SLC75A1 solute carrier family 75 member 1 3.29375
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.24972
FZD7 frizzled class receptor 7 3.2274
MSRA methionine sulfoxide reductase A 3.22
ADRB2 adrenoceptor beta 2, surface 3.16815
TBKBP1 TBK1 binding protein 1 3.13365
EVA1B eva-1 homolog B (C. elegans) 3.11468
NUP133 nucleoporin 133kDa 2.97925
MAP7 microtubule-associated protein 7 2.97738
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.90363
CCNF cyclin F 2.78522
SYTL2 synaptotagmin-like 2 2.7647
GPATCH8 G patch domain containing 8 2.7496
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 2.7478
SIPA1 signal-induced proliferation-associated 1 2.7096
ANO1 anoctamin 1, calcium activated chloride channel 2.69155
JADE2 jade family PHD finger 2 2.6512
SFTPB surfactant protein B 2.61698
WWC3 WWC family member 3 2.5822
TBCA tubulin folding cofactor A 2.56305
POMP proteasome maturation protein 2.5339
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.44665
RAB21 RAB21, member RAS oncogene family 2.43855
WNT16 wingless-type MMTV integration site family, member 16 2.42905
XAB2 XPA binding protein 2 2.42525
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.4125
NKX3-2 NK3 homeobox 2 2.3491
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 2.32345
STXBP1 syntaxin binding protein 1 2.27695
NLRP4 NLR family, pyrin domain containing 4 2.2768
CRAT carnitine O-acetyltransferase 2.23568
ARID4B AT rich interactive domain 4B (RBP1-like) 2.2308
LDLRAD4 low density lipoprotein receptor class A domain containing 4 2.20003
CYCS cytochrome c, somatic 2.18575
ATP5ME ATP synthase membrane subunit e 2.18003
SRPK3 SRSF protein kinase 3 2.1728
KDM5A lysine (K)-specific demethylase 5A 2.15583
ETNK2 ethanolamine kinase 2 2.1523
TBK1 TANK-binding kinase 1 2.14655
PROCR protein C receptor, endothelial 2.14375
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.1429
NDOR1 NADPH dependent diflavin oxidoreductase 1 2.12525
CSDC2 cold shock domain containing C2, RNA binding 2.117
CD72 CD72 molecule 2.1169
SORBS3 sorbin and SH3 domain containing 3 2.10345
SOX12 SRY (sex determining region Y)-box 12 2.0844
COL10A1 collagen, type X, alpha 1 2.07197
RAB1B RAB1B, member RAS oncogene family 2.0667
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.0634
FKBP10 FK506 binding protein 10, 65 kDa 2.05785
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 2.05325
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2.04995
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.04365
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.03675
MLYCD malonyl-CoA decarboxylase 2.0348
KIF18B kinesin family member 18B 2.0334
RSF1 remodeling and spacing factor 1 2.01865
FHOD1 formin homology 2 domain containing 1 2.01815
GRN granulin 2.00872
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 2.00135

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -6.5586
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.4069
ARID5B AT rich interactive domain 5B (MRF1-like) -5.21605
CCNB2 cyclin B2 -5.16155
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -5.15585
LDHD lactate dehydrogenase D -4.81795
CAB39 calcium binding protein 39 -4.51015
EIF5 eukaryotic translation initiation factor 5 -4.32465
DNM1L dynamin 1-like -4.0529
SPAG4 sperm associated antigen 4 -3.95585
PSRC1 proline/serine-rich coiled-coil 1 -3.8466
LOC124907782 dual specificity protein phosphatase 22 -3.54225
NRIP1 nuclear receptor interacting protein 1 -3.51562
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.51535
TLCD3A TLC domain containing 3A -3.4885
CCDC92 coiled-coil domain containing 92 -3.37595
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.34715
CCNB1 cyclin B1 -3.0452
TCTN1 tectonic family member 1 -3.01345
EXT1 exostosin glycosyltransferase 1 -2.97902
DERA deoxyribose-phosphate aldolase (putative) -2.8599
GET1 guided entry of tail-anchored proteins factor 1 -2.8278
STMN1 stathmin 1 -2.6997
TBC1D31 TBC1 domain family, member 31 -2.6979
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -2.65819
CETN2 centrin, EF-hand protein, 2 -2.60605
IPO13 importin 13 -2.5473
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 -2.53975
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 -2.4863
ITGB1BP1 integrin beta 1 binding protein 1 -2.45555
CBR1 carbonyl reductase 1 -2.44995
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 -2.44795
RSU1 Ras suppressor protein 1 -2.43105
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.42525
PECR peroxisomal trans-2-enoyl-CoA reductase -2.41445
TOR3A torsin family 3, member A -2.3939
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.39095
CLTB clathrin, light chain B -2.33891
PPP1R7 protein phosphatase 1, regulatory subunit 7 -2.31015
POLR3B polymerase (RNA) III (DNA directed) polypeptide B -2.28805
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) -2.27465
FKBP14 FK506 binding protein 14, 22 kDa -2.18905
HMOX1 heme oxygenase 1 -2.1568
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 -2.14208
TXNL4B thioredoxin-like 4B -2.1418
BLCAP bladder cancer associated protein -2.1353
WARS1 tryptophanyl-tRNA synthetase 1 -2.13377
LOC124900388 uncharacterized LOC124900388 -2.10595
COPS5 COP9 signalosome subunit 5 -2.08895
MACROH2A2 macroH2A.2 histone -2.0738
HDAC4 histone deacetylase 4 -2.0736
CYREN cell cycle regulator of NHEJ -2.07045
MNS1 meiosis-specific nuclear structural 1 -2.0632
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 -2.0605
FOXJ1 forkhead box J1 -2.0538
PPOX protoporphyrinogen oxidase -2.047
CTNNA2 catenin (cadherin-associated protein), alpha 2 -2.03575
CBY1 chibby homolog 1 (Drosophila) -2.03395
PHLDA3 pleckstrin homology-like domain, family A, member 3 -2.01785
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.00163