CRCGN014_HEPG2_3H:L14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenobarbital, sodium 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN014_HEPG2_3H:L14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.38577
CSK c-src tyrosine kinase 4.87582
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.52337
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.50882
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.44833
PLSCR3 phospholipid scramblase 3 4.32788
ADGRE5 adhesion G protein-coupled receptor E5 4.31206
ANO1 anoctamin 1, calcium activated chloride channel 4.10579
PPARG peroxisome proliferator-activated receptor gamma 4.09791
CCL2 chemokine (C-C motif) ligand 2 3.95674
SNAP25 synaptosomal-associated protein, 25kDa 3.9391
SATB1 SATB homeobox 1 3.61913
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.60037
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.48606
TREM1 triggering receptor expressed on myeloid cells 1 3.25888
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.18598
LOC122526780 uncharacterized LOC122526780 3.00449
KIF14 kinesin family member 14 2.92407
CHN1 chimerin 1 2.88619
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.65084
EVL Enah/Vasp-like 2.59782
CDC45 cell division cycle 45 2.50471
GPER1 G protein-coupled estrogen receptor 1 2.32533
CCNF cyclin F 2.25963
GARRE1 granule associated Rac and RHOG effector 1 2.21879
MAP7 microtubule-associated protein 7 2.17172
SIRT3 sirtuin 3 2.15933
OSBPL9 oxysterol binding protein-like 9 2.061
CORO1A coronin, actin binding protein, 1A 2.04983
HYOU1 hypoxia up-regulated 1 2.04725
FIBP fibroblast growth factor (acidic) intracellular binding protein 2.0197
SSBP2 single-stranded DNA binding protein 2 2.01699
TBP TATA box binding protein 2.00624

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -6.7277
LDHD lactate dehydrogenase D -5.35475
CCNB2 cyclin B2 -4.57696
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -4.50294
TUBB6 tubulin, beta 6 class V -4.36284
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.28313
TRIB3 tribbles pseudokinase 3 -3.91427
TLCD3A TLC domain containing 3A -3.31367
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.28664
GNAS GNAS complex locus -3.18478
ACAA1 acetyl-CoA acyltransferase 1 -3.12159
CCNB1 cyclin B1 -2.99761
GRB7 growth factor receptor-bound protein 7 -2.59419
STARD3 StAR-related lipid transfer (START) domain containing 3 -2.53545
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.43049
EDN3 endothelin 3 -2.41587
UBE3C ubiquitin protein ligase E3C -2.36076
PPOX protoporphyrinogen oxidase -2.14142
HLA-DMA major histocompatibility complex, class II, DM alpha -2.09352
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -2.07192
CDCP1 CUB domain containing protein 1 -2.05131
TCEAL9 transcription elongation factor A like 9 -2.01523
PGAP3 post-GPI attachment to proteins 3 -2.00786