CRCGN014_HEPG2_3H:L15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description urea 42.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN014_HEPG2_3H:L15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 6.4019
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 5.45303
MAP7 microtubule-associated protein 7 5.04558
GPER1 G protein-coupled estrogen receptor 1 4.45445
CGRRF1 cell growth regulator with ring finger domain 1 3.77577
PPARG peroxisome proliferator-activated receptor gamma 3.58617
CXCL2 chemokine (C-X-C motif) ligand 2 3.47677
CCNA1 cyclin A1 3.47043
CIAO3 cytosolic iron-sulfur assembly component 3 3.4629
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.4196
BZW2 basic leucine zipper and W2 domains 2 3.34203
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.2812
E2F2 E2F transcription factor 2 3.27313
CCL2 chemokine (C-C motif) ligand 2 3.25873
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.11313
SMIM40 small integral membrane protein 40 2.94073
MYLK myosin light chain kinase 2.90487
NOSIP nitric oxide synthase interacting protein 2.855
LOC122526780 uncharacterized LOC122526780 2.80893
GATA2 GATA binding protein 2 2.66667
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.5746
PRKCH protein kinase C, eta 2.44022
CTTN cortactin 2.38017
PGAM4 phosphoglycerate mutase family member 4 2.33777
S100A3 S100 calcium binding protein A3 2.31673
FGF8 fibroblast growth factor 8 (androgen-induced) 2.24307
CCL5 chemokine (C-C motif) ligand 5 2.1841
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2.0929
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 2.0912
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 2.07053
BMP4 bone morphogenetic protein 4 2.06307
CORO1A coronin, actin binding protein, 1A 2.01113

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -6.36343
GNAS GNAS complex locus -5.01624
OXA1L oxidase (cytochrome c) assembly 1-like -4.79003
MAPK13 mitogen-activated protein kinase 13 -4.49765
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.85283
NUP85 nucleoporin 85kDa -3.51883
PCCB propionyl CoA carboxylase, beta polypeptide -3.50267
LDHD lactate dehydrogenase D -3.2622
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.25735
STK25 serine/threonine kinase 25 -3.2111
SCAND1 SCAN domain containing 1 -3.13717
PCNA proliferating cell nuclear antigen -3.1085
CCDC86 coiled-coil domain containing 86 -2.98323
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.708
CCNH cyclin H -2.70003
ISOC1 isochorismatase domain containing 1 -2.57747
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.39893
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.3719
ZNF586 zinc finger protein 586 -2.3444
SNX11 sorting nexin 11 -2.2982
RHEB Ras homolog enriched in brain -2.15421
NECAP1 NECAP endocytosis associated 1 -2.08277
FGFR4 fibroblast growth factor receptor 4 -2.05502
CAB39 calcium binding protein 39 -2.02727