CRCGN014_HEPG2_3H:L17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-phenylazo-2-naphthol 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

65 genes differentially expressed following the CRCGN014_HEPG2_3H:L17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 6.91048
GSTZ1 glutathione S-transferase zeta 1 5.82617
LCN2 lipocalin 2 5.77468
TIAM1 T-cell lymphoma invasion and metastasis 1 4.74863
PNKP polynucleotide kinase 3'-phosphatase 3.76171
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.59224
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.52856
ANO1 anoctamin 1, calcium activated chloride channel 3.43691
UBQLN2 ubiquilin 2 3.3758
ADRB2 adrenoceptor beta 2, surface 3.33653
JADE2 jade family PHD finger 2 3.30545
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.27549
RPL39L ribosomal protein L39-like 3.25302
RAP1GAP RAP1 GTPase activating protein 3.24489
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.16171
SORBS3 sorbin and SH3 domain containing 3 3.10058
CXCL2 chemokine (C-X-C motif) ligand 2 3.05451
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.87517
HSPA1A heat shock 70kDa protein 1A 2.83666
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.7339
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.71672
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.54982
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.50463
CCDC86 coiled-coil domain containing 86 2.49579
SKIC8 SKI8 subunit of superkiller complex 2.32294
ELAC2 elaC ribonuclease Z 2 2.23131
FAM171A1 family with sequence similarity 171, member A1 2.20034
USP6NL USP6 N-terminal like 2.17113
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.15003
TTC19 tetratricopeptide repeat domain 19 2.12121
STIMATE STIM activating enhancer 2.10928
PRKCH protein kinase C, eta 2.09301
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.03184
CTC1 CTS telomere maintenance complex component 1 2.0285
FHIT fragile histidine triad 2.02199
ABHD6 abhydrolase domain containing 6 2.00506

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -6.39874
OXA1L oxidase (cytochrome c) assembly 1-like -4.82402
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.27372
TMEM109 transmembrane protein 109 -3.80996
CCNB2 cyclin B2 -3.53477
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.33195
GOLT1B golgi transport 1B -3.31539
ZDHHC6 zinc finger, DHHC-type containing 6 -3.29461
TCERG1 transcription elongation regulator 1 -3.26009
TLR4 toll-like receptor 4 -3.25395
PCNA proliferating cell nuclear antigen -3.08068
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.83309
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.76895
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.67329
CAB39 calcium binding protein 39 -2.56832
MAPK13 mitogen-activated protein kinase 13 -2.55413
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.51012
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.50327
GNAS GNAS complex locus -2.40888
CCNB1 cyclin B1 -2.23444
AURKB aurora kinase B -2.19814
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 -2.16076
PDE3A phosphodiesterase 3A, cGMP-inhibited -2.14187
INHBE inhibin, beta E -2.12927
MSMO1 methylsterol monooxygenase 1 -2.11786
ADIPOR2 adiponectin receptor 2 -2.11511
ZDHHC18 zinc finger, DHHC-type containing 18 -2.0044
ISOC1 isochorismatase domain containing 1 -2.00162
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.00053