CRCGN014_HEPG2_3H:L19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetrakis(hydroxymethyl)phos-phonium chloride 40.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

75 genes differentially expressed following the CRCGN014_HEPG2_3H:L19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 10.0
MYLK myosin light chain kinase 6.57477
TBC1D10C TBC1 domain family, member 10C 6.34849
HYOU1 hypoxia up-regulated 1 4.96494
ANO1 anoctamin 1, calcium activated chloride channel 4.61423
EVL Enah/Vasp-like 4.36884
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.35211
GSTZ1 glutathione S-transferase zeta 1 4.26398
MAMLD1 mastermind-like domain containing 1 4.02193
CIAO3 cytosolic iron-sulfur assembly component 3 3.91137
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.84101
SLC35B1 solute carrier family 35, member B1 3.69247
INTS3 integrator complex subunit 3 3.64311
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.48278
HDGFL3 HDGF like 3 3.44634
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.38945
DYNLT3 dynein, light chain, Tctex-type 3 3.32044
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.0427
CYCS cytochrome c, somatic 3.03002
STIMATE STIM activating enhancer 2.96983
MOK MOK protein kinase 2.96383
PNKP polynucleotide kinase 3'-phosphatase 2.90136
UBQLN2 ubiquilin 2 2.78194
CXCL2 chemokine (C-X-C motif) ligand 2 2.67204
KDM5A lysine (K)-specific demethylase 5A 2.63104
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 2.61589
KLHL9 kelch-like family member 9 2.45017
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.32923
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.31575
MANF mesencephalic astrocyte-derived neurotrophic factor 2.29946
TRIM22 tripartite motif containing 22 2.24189
PEX11A peroxisomal biogenesis factor 11 alpha 2.24081
KRCC1 lysine-rich coiled-coil 1 2.23784
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.23134
GC group-specific component (vitamin D binding protein) 2.22827
AARS1 alanyl-tRNA synthetase 1 2.21334
MEST mesoderm specific transcript 2.18865
ARID4B AT rich interactive domain 4B (RBP1-like) 2.16491
NCK1 NCK adaptor protein 1 2.15123
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.13996
HOXA10 homeobox A10 2.10498
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 2.09279
SEC63 SEC63 homolog (S. cerevisiae) 2.08137
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.07614
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.0604
FADD Fas (TNFRSF6)-associated via death domain 2.05676
LOC128125814 uncharacterized LOC128125814 2.05496
BET1 Bet1 golgi vesicular membrane trafficking protein 2.02439
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.00657
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.00271

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.39707
CCNB2 cyclin B2 -6.06159
NGRN neugrin, neurite outgrowth associated -4.45172
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.43987
GNAS GNAS complex locus -4.32659
PRPF4 pre-mRNA processing factor 4 -4.17653
DSG2 desmoglein 2 -3.91291
PCNA proliferating cell nuclear antigen -3.74835
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.49548
ADI1 acireductone dioxygenase 1 -3.34213
TLCD3A TLC domain containing 3A -3.27338
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.94605
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.93129
HSPA1A heat shock 70kDa protein 1A -2.8729
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.72385
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.56484
CCNB1 cyclin B1 -2.41974
SNX11 sorting nexin 11 -2.27884
SLC35F2 solute carrier family 35, member F2 -2.22424
PSRC1 proline/serine-rich coiled-coil 1 -2.22053
ACLY ATP citrate lyase -2.18235
MAP6D1 MAP6 domain containing 1 -2.0919
INO80D INO80 complex subunit D -2.06276
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.04534
ATG10 autophagy related 10 -2.01653