CRCGN014_HEPG2_3H:L20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description [1,1'-biphenyl]-3,3',4,4'-tetramine tetrahydrochloride 19.99 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN014_HEPG2_3H:L20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 9.27806
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.1018
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.75217
CHN1 chimerin 1 4.72762
CCL2 chemokine (C-C motif) ligand 2 4.56289
KLHL21 kelch-like family member 21 4.54522
CSK c-src tyrosine kinase 4.53472
TREM1 triggering receptor expressed on myeloid cells 1 4.27237
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.09313
MEST mesoderm specific transcript 3.46427
HOXA10 homeobox A10 3.42743
MAP7 microtubule-associated protein 7 3.39887
GSTZ1 glutathione S-transferase zeta 1 3.29011
GPATCH8 G patch domain containing 8 3.18132
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.95988
GPER1 G protein-coupled estrogen receptor 1 2.90194
TIAM1 T-cell lymphoma invasion and metastasis 1 2.82885
IDE insulin-degrading enzyme 2.80486
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.5692
EGF epidermal growth factor 2.52421
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.30413
DDIT4 DNA-damage-inducible transcript 4 2.22603
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 2.0131

decreased expression

Symbol Name Standardized Value
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -6.25176
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.97534
PTPRK protein tyrosine phosphatase, receptor type, K -4.54602
TUBB6 tubulin, beta 6 class V -4.28732
DERA deoxyribose-phosphate aldolase (putative) -3.98888
CCNB2 cyclin B2 -3.96499
OXA1L oxidase (cytochrome c) assembly 1-like -3.46889
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.91465
HLA-DMA major histocompatibility complex, class II, DM alpha -2.58084
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.41019
PSRC1 proline/serine-rich coiled-coil 1 -2.33947
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.22319
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.13191
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.11849
CCND3 cyclin D3 -2.07996
NTSR1 neurotensin receptor 1 (high affinity) -2.02668
NUSAP1 nucleolar and spindle associated protein 1 -2.0142