CRCGN014_HEPG2_3H:L21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tegafur 20.82 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

101 genes differentially expressed following the CRCGN014_HEPG2_3H:L21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 7.74076
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.29575
CYCS cytochrome c, somatic 5.08012
PPARG peroxisome proliferator-activated receptor gamma 4.21398
TAC4 tachykinin 4 (hemokinin) 4.02328
ADRB2 adrenoceptor beta 2, surface 3.8002
DYNLT3 dynein, light chain, Tctex-type 3 3.64255
PHKG2 phosphorylase kinase, gamma 2 (testis) 3.51104
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.37345
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.34497
SNAP25 synaptosomal-associated protein, 25kDa 3.29729
EVL Enah/Vasp-like 3.17287
ZBTB18 zinc finger and BTB domain containing 18 3.05415
EGR1 early growth response 1 2.93879
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.91235
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.90818
CIAO3 cytosolic iron-sulfur assembly component 3 2.88991
KIF14 kinesin family member 14 2.85903
ABHD6 abhydrolase domain containing 6 2.83093
LCN2 lipocalin 2 2.83035
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.77097
PFKL phosphofructokinase, liver 2.74281
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.69062
HAPLN2 hyaluronan and proteoglycan link protein 2 2.64856
CRK v-crk avian sarcoma virus CT10 oncogene homolog 2.63819
TIAM1 T-cell lymphoma invasion and metastasis 1 2.62756
USB1 U6 snRNA biogenesis 1 2.57694
APLP1 amyloid beta (A4) precursor-like protein 1 2.5342
CXCL2 chemokine (C-X-C motif) ligand 2 2.53304
SLC25A46 solute carrier family 25, member 46 2.51249
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.45797
SLC4A3 solute carrier family 4 (anion exchanger), member 3 2.37697
GPER1 G protein-coupled estrogen receptor 1 2.36543
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 2.35004
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.33427
HSF4 heat shock transcription factor 4 2.29199
DRD4 dopamine receptor D4 2.27882
ZNF446 zinc finger protein 446 2.2623
STIMATE STIM activating enhancer 2.23236
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.22946
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.20587
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.19038
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 2.18844
JADE2 jade family PHD finger 2 2.18828
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.17962
PRDM8 PR domain containing 8 2.16891
MAPK4 mitogen-activated protein kinase 4 2.16588
PAX1 paired box 1 2.15998
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.15883
SCAMP5 secretory carrier membrane protein 5 2.1557
PLCH2 phospholipase C, eta 2 2.15226
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.14402
GBX1 gastrulation brain homeobox 1 2.14364
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.12087
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 2.10904
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.0601
SPINT2 serine peptidase inhibitor, Kunitz type, 2 2.0584
TMEM59L transmembrane protein 59-like 2.05798
ANO1 anoctamin 1, calcium activated chloride channel 2.05041
SBNO1 strawberry notch homolog 1 (Drosophila) 2.03751
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 2.03313
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 2.02679
FBXO2 F-box protein 2 2.02487
GP9 glycoprotein IX (platelet) 2.02294
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 2.01857
BOLA2B bolA family member 2B 2.01823

decreased expression

Symbol Name Standardized Value
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -7.39374
TUBB6 tubulin, beta 6 class V -6.81593
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.63602
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.07536
GTPBP8 GTP-binding protein 8 (putative) -4.59102
VAT1 vesicle amine transport 1 -4.2783
GNAS GNAS complex locus -4.25594
KDM3A lysine (K)-specific demethylase 3A -4.20234
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.815
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.65899
OXA1L oxidase (cytochrome c) assembly 1-like -3.62818
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.46417
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.34821
PRPF4 pre-mRNA processing factor 4 -3.32546
NCK1 NCK adaptor protein 1 -3.2525
LDHD lactate dehydrogenase D -3.12985
CCNB2 cyclin B2 -3.10897
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.93126
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.86869
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.7408
EXT1 exostosin glycosyltransferase 1 -2.62768
NES nestin -2.54149
BAMBI BMP and activin membrane-bound inhibitor -2.49224
PLEKHA5 pleckstrin homology domain containing, family A member 5 -2.46549
DNM1L dynamin 1-like -2.35616
GLOD4 glyoxalase domain containing 4 -2.29648
WDR7 WD repeat domain 7 -2.2699
EGF epidermal growth factor -2.264
SOAT2 sterol O-acyltransferase 2 -2.24822
ACP2 acid phosphatase 2, lysosomal -2.20535
C2CD5 C2 calcium-dependent domain containing 5 -2.12545
HMG20B high mobility group 20B -2.11298
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -2.05801
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -2.04387
DERA deoxyribose-phosphate aldolase (putative) -2.00196