CRCGN014_HEPG2_3H:L23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN014_HEPG2_3H:L23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 5.8604
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.13358
PRR15L proline rich 15-like 4.11813
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.85479
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.71308
PPARG peroxisome proliferator-activated receptor gamma 3.70123
UBQLN2 ubiquilin 2 3.53503
EPN2 epsin 2 3.51396
SFTPB surfactant protein B 3.49087
RPP38 ribonuclease P/MRP 38kDa subunit 3.47269
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.37103
ABHD6 abhydrolase domain containing 6 3.35958
CCL2 chemokine (C-C motif) ligand 2 3.30277
DYNLT3 dynein, light chain, Tctex-type 3 3.09276
CNPY3 canopy FGF signaling regulator 3 2.69002
TLR4 toll-like receptor 4 2.48471
KIF14 kinesin family member 14 2.40668
MSRA methionine sulfoxide reductase A 2.40191
MOK MOK protein kinase 2.24198
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.18347
PLSCR3 phospholipid scramblase 3 2.15959
ZNF589 zinc finger protein 589 2.13435
SNAP25 synaptosomal-associated protein, 25kDa 2.06378
KRI1 KRI1 homolog (S. cerevisiae) 2.02327

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -7.35032
TLCD3A TLC domain containing 3A -5.26591
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.3542
SCAND1 SCAN domain containing 1 -4.27494
VAT1 vesicle amine transport 1 -3.92561
TRIB3 tribbles pseudokinase 3 -3.87391
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.81836
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.69359
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.61141
BPHL biphenyl hydrolase-like (serine hydrolase) -3.59738
TUBB6 tubulin, beta 6 class V -3.44555
KDM3A lysine (K)-specific demethylase 3A -3.25211
CDC20 cell division cycle 20 -3.20945
MAPK13 mitogen-activated protein kinase 13 -3.00332
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.7075
FAIM Fas apoptotic inhibitory molecule -2.685
PRPF4 pre-mRNA processing factor 4 -2.46665
ZNF586 zinc finger protein 586 -2.46498
GOLT1B golgi transport 1B -2.45974
UGDH UDP-glucose 6-dehydrogenase -2.40316
GMPR guanosine monophosphate reductase -2.31427
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.27247
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.26043
HAT1 histone acetyltransferase 1 -2.2274
MCOLN3 mucolipin 3 -2.12112
RAB38 RAB38, member RAS oncogene family -2.01611
TTC13 tetratricopeptide repeat domain 13 -2.00758