CRCGN014_HEPG2_3H:M01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tris(1,3-dichloro-2-propyl) phosphate 39.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

193 genes differentially expressed following the CRCGN014_HEPG2_3H:M01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 8.07377
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 7.02069
DDIT4 DNA-damage-inducible transcript 4 6.87082
GSTZ1 glutathione S-transferase zeta 1 6.23834
STK10 serine/threonine kinase 10 6.05097
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.85132
LPAR2 lysophosphatidic acid receptor 2 5.79244
CBR3 carbonyl reductase 3 5.01469
PNKP polynucleotide kinase 3'-phosphatase 4.87802
CHMP6 charged multivesicular body protein 6 4.5131
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.20172
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 4.03308
MEST mesoderm specific transcript 4.01181
AMDHD2 amidohydrolase domain containing 2 3.9951
PMM2 phosphomannomutase 2 3.66913
ADAM10 ADAM metallopeptidase domain 10 3.58717
CXCL2 chemokine (C-X-C motif) ligand 2 3.46337
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.45285
NOSIP nitric oxide synthase interacting protein 3.41423
SHB Src homology 2 domain containing adaptor protein B 3.23081
BIN2 bridging integrator 2 3.19534
TRIB3 tribbles pseudokinase 3 3.0578
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 3.03501
KLHL9 kelch-like family member 9 3.02492
RGPD1 RANBP2-like and GRIP domain containing 1 2.91364
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.83669
MYO1F myosin IF 2.77387
AARS1 alanyl-tRNA synthetase 1 2.71908
UCN urocortin 2.7065
POM121 POM121 transmembrane nucleoporin 2.64937
SAMD9 sterile alpha motif domain containing 9 2.62148
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.62064
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 2.60991
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 2.60139
BTK Bruton agammaglobulinemia tyrosine kinase 2.57308
HIC2 hypermethylated in cancer 2 2.55437
DEF6 differentially expressed in FDCP 6 homolog (mouse) 2.53395
MYBPC2 myosin binding protein C, fast type 2.50967
JADE2 jade family PHD finger 2 2.47016
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 2.45911
IL11RA interleukin 11 receptor, alpha 2.44595
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.44225
NMD3 NMD3 ribosome export adaptor 2.43861
CDK19 cyclin-dependent kinase 19 2.43822
PRKCZ protein kinase C, zeta 2.43403
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.43365
RIGI RNA sensor RIG-I 2.41996
TBP TATA box binding protein 2.40916
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.38524
SLAMF7 SLAM family member 7 2.37798
LDLRAP1 low density lipoprotein receptor adaptor protein 1 2.37228
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.33335
LSR lipolysis stimulated lipoprotein receptor 2.33043
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 2.33028
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) 2.32367
PARP11 poly (ADP-ribose) polymerase family, member 11 2.3205
APOBR apolipoprotein B receptor 2.31267
DBF4B DBF4 zinc finger B 2.28845
EZR ezrin 2.28505
CLEC2D C-type lectin domain family 2, member D 2.25771
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.2558
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.24941
L1TD1 LINE-1 type transposase domain containing 1 2.24811
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.24503
TESK1 testis-specific kinase 1 2.23677
CCDC22 coiled-coil domain containing 22 2.22884
KANK1 KN motif and ankyrin repeat domains 1 2.2261
PILRB paired immunoglobin-like type 2 receptor beta 2.2245
KRT20 keratin 20, type I 2.21119
DGCR2 DiGeorge syndrome critical region gene 2 2.20125
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.19955
HNF4G hepatocyte nuclear factor 4, gamma 2.18901
UBQLN2 ubiquilin 2 2.18459
CLCA2 chloride channel accessory 2 2.18392
IRGC immunity-related GTPase family, cinema 2.18195
DYNLT1 dynein, light chain, Tctex-type 1 2.18154
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.17513
TIAM1 T-cell lymphoma invasion and metastasis 1 2.17349
NEUROG3 neurogenin 3 2.17289
ORC3 origin recognition complex, subunit 3 2.16704
ADAP2 ArfGAP with dual PH domains 2 2.16682
ATP13A1 ATPase type 13A1 2.16558
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.15061
EPCAM epithelial cell adhesion molecule 2.15012
BCL2L13 BCL2-like 13 (apoptosis facilitator) 2.14842
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.14581
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.13213
NAGK N-acetylglucosamine kinase 2.13053
CASP1 caspase 1, apoptosis-related cysteine peptidase 2.13029
ZIC3 Zic family member 3 2.12578
DGCR6L DiGeorge syndrome critical region gene 6-like 2.12235
KLRG1 killer cell lectin-like receptor subfamily G, member 1 2.09929
TXNIP thioredoxin interacting protein 2.09403
ARHGAP4 Rho GTPase activating protein 4 2.08665
EVL Enah/Vasp-like 2.08413
EHF ets homologous factor 2.0839
MED15 mediator complex subunit 15 2.07677
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.07296
WDR46 WD repeat domain 46 2.0727
PXDNL peroxidasin-like 2.07267
GALT galactose-1-phosphate uridylyltransferase 2.06964
RAP1GAP2 RAP1 GTPase activating protein 2 2.06922
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.06619
HOXA10 homeobox A10 2.06594
VASH1 vasohibin 1 2.0513
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.046
GABPA GA binding protein transcription factor, alpha subunit 60kDa 2.04266
WDR25 WD repeat domain 25 2.04227
POU5F1 POU class 5 homeobox 1 2.0383
CDK8 cyclin-dependent kinase 8 2.03721
ARID3A AT rich interactive domain 3A (BRIGHT-like) 2.03645
UFSP2 UFM1-specific peptidase 2 2.03325
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 2.02611
KHDC1L KH homology domain containing 1-like 2.01885
RIN3 Ras and Rab interactor 3 2.0186
FGD6 FYVE, RhoGEF and PH domain containing 6 2.01486
ATXN7L1 ataxin 7-like 1 2.01215
GAL3ST1 galactose-3-O-sulfotransferase 1 2.00974
CCDC82 coiled-coil domain containing 82 2.0097
GAL3ST4 galactose-3-O-sulfotransferase 4 2.00517
BSG basigin (Ok blood group) 2.00508
BANP BTG3 associated nuclear protein 2.00455
CDK11A cyclin-dependent kinase 11A 2.00117

decreased expression

Symbol Name Standardized Value
FASTKD5 FAST kinase domains 5 -8.37163
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.907
GNAS GNAS complex locus -4.93991
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.11183
NT5DC2 5'-nucleotidase domain containing 2 -3.83484
CAB39 calcium binding protein 39 -3.72058
SCAND1 SCAN domain containing 1 -3.69251
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.6529
TM9SF3 transmembrane 9 superfamily member 3 -3.52197
CCNH cyclin H -3.50011
PCNA proliferating cell nuclear antigen -3.413
COG7 component of oligomeric golgi complex 7 -3.36736
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.36153
THAP11 THAP domain containing 11 -3.23008
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.18144
HEATR1 HEAT repeat containing 1 -3.15814
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.12529
TOR1A torsin family 1, member A (torsin A) -3.01007
TOMM34 translocase of outer mitochondrial membrane 34 -2.88143
SLC35F2 solute carrier family 35, member F2 -2.86687
TLCD3A TLC domain containing 3A -2.78376
BPHL biphenyl hydrolase-like (serine hydrolase) -2.77481
WDR7 WD repeat domain 7 -2.71969
ETFB electron-transfer-flavoprotein, beta polypeptide -2.57791
SNX11 sorting nexin 11 -2.55583
FN1 fibronectin 1 -2.52487
RALY RALY heterogeneous nuclear ribonucleoprotein -2.52347
GRWD1 glutamate-rich WD repeat containing 1 -2.51451
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.50316
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -2.44695
ACAA1 acetyl-CoA acyltransferase 1 -2.43968
CRTAP cartilage associated protein -2.43851
FOS FBJ murine osteosarcoma viral oncogene homolog -2.42038
OXA1L oxidase (cytochrome c) assembly 1-like -2.41186
AAR2 AAR2 splicing factor homolog (S. cerevisiae) -2.40851
ZW10 zw10 kinetochore protein -2.39365
ANXA7 annexin A7 -2.39327
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 -2.38943
TMA7 translation machinery associated 7 homolog (S. cerevisiae) -2.37905
RXYLT1 ribitol xylosyltransferase 1 -2.36971
NUP85 nucleoporin 85kDa -2.35672
RPGR retinitis pigmentosa GTPase regulator -2.349
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough -2.34416
PTMA prothymosin, alpha -2.32252
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.31604
ILKAP integrin-linked kinase-associated serine/threonine phosphatase -2.31546
NKAPD1 NKAP domain containing 1 -2.27072
CCNB1 cyclin B1 -2.2319
TUBB6 tubulin, beta 6 class V -2.22305
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.22034
CHD9NB CHD9 neighbor -2.21355
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -2.1944
GLOD4 glyoxalase domain containing 4 -2.15267
NUAK1 NUAK family, SNF1-like kinase, 1 -2.14744
NFS1 NFS1 cysteine desulfurase -2.12877
ATRN attractin -2.12664
REEP5 receptor accessory protein 5 -2.10134
NUP93 nucleoporin 93kDa -2.09926
DCPS decapping enzyme, scavenger -2.09481
NCOA6 nuclear receptor coactivator 6 -2.09228
RNASE7 ribonuclease, RNase A family, 7 -2.06727
NME4 NME/NM23 nucleoside diphosphate kinase 4 -2.06415
FBXL2 F-box and leucine-rich repeat protein 2 -2.06406
UCK2 uridine-cytidine kinase 2 -2.04569
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.04025
ATG9A autophagy related 9A -2.03529
CNTNAP1 contactin associated protein 1 -2.03508
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 -2.02866
TUBA1C tubulin, alpha 1c -2.01799
ZDHHC24 zinc finger, DHHC-type containing 24 -2.0