CRCGN014_HEPG2_3H:M02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description triphenyl phosphate 39.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

100 genes differentially expressed following the CRCGN014_HEPG2_3H:M02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 10.0
PPARG peroxisome proliferator-activated receptor gamma 6.97236
EGR1 early growth response 1 6.52129
TRIB3 tribbles pseudokinase 3 5.40713
NFIL3 nuclear factor, interleukin 3 regulated 4.6052
CIAO3 cytosolic iron-sulfur assembly component 3 4.56885
IER3 immediate early response 3 4.22073
MYC v-myc avian myelocytomatosis viral oncogene homolog 4.13766
BACE2 beta-site APP-cleaving enzyme 2 3.99946
CCP110 centriolar coiled coil protein 110kDa 3.77854
SCRN1 secernin 1 3.48798
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.4733
TRIB1 tribbles pseudokinase 1 3.45173
JADE2 jade family PHD finger 2 3.40871
GPATCH8 G patch domain containing 8 3.319
GOLT1B golgi transport 1B 3.30011
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.29903
CSK c-src tyrosine kinase 3.23052
PRR15L proline rich 15-like 3.20579
DIPK1A divergent protein kinase domain 1A 3.15128
FOSL1 FOS-like antigen 1 3.09056
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.06223
CBR3 carbonyl reductase 3 3.05765
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.05447
LOC128125814 uncharacterized LOC128125814 3.05135
ZFP36 ZFP36 ring finger protein 3.03841
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.94927
TATDN2 TatD DNase domain containing 2 2.88735
NOSIP nitric oxide synthase interacting protein 2.85071
C2CD2 C2 calcium-dependent domain containing 2 2.74384
BHLHE40 basic helix-loop-helix family, member e40 2.73854
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.6794
GATA2 GATA binding protein 2 2.63629
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.63629
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.57216
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.49954
DYNLT3 dynein, light chain, Tctex-type 3 2.4927
AARS1 alanyl-tRNA synthetase 1 2.41041
CHN1 chimerin 1 2.38669
ICAM1 intercellular adhesion molecule 1 2.37563
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.37066
SMAGP small cell adhesion glycoprotein 2.36814
PRPF38B pre-mRNA processing factor 38B 2.29734
ADGRG1 adhesion G protein-coupled receptor G1 2.27714
CARMIL1 capping protein regulator and myosin 1 linker 1 2.24874
ATP11B ATPase, class VI, type 11B 2.23447
PTK2 protein tyrosine kinase 2 2.21542
CYCS cytochrome c, somatic 2.15864
TERF2IP telomeric repeat binding factor 2, interacting protein 2.14548
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.12372
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.0995
SARS1 seryl-tRNA synthetase 1 2.09378
EAPP E2F-associated phosphoprotein 2.05431
IFRD1 interferon-related developmental regulator 1 2.04812
CHMP6 charged multivesicular body protein 6 2.03242
ASCC1 activating signal cointegrator 1 complex subunit 1 2.03017
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.02358
TMEM123 transmembrane protein 123 2.01767

decreased expression

Symbol Name Standardized Value
FASTKD5 FAST kinase domains 5 -9.9514
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.78001
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.66143
HMG20B high mobility group 20B -4.44778
CDC25B cell division cycle 25B -4.43091
UGDH UDP-glucose 6-dehydrogenase -4.0269
PSRC1 proline/serine-rich coiled-coil 1 -3.76311
CCNB2 cyclin B2 -3.54336
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.49255
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.29335
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.08974
CCNB1 cyclin B1 -3.05152
PYCR1 pyrroline-5-carboxylate reductase 1 -2.99553
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -2.97693
ANKRD10 ankyrin repeat domain 10 -2.88457
THAP11 THAP domain containing 11 -2.82847
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.82051
WDR7 WD repeat domain 7 -2.81973
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.79515
GNAS GNAS complex locus -2.70375
GET1 guided entry of tail-anchored proteins factor 1 -2.59258
PEX26 peroxisomal biogenesis factor 26 -2.5695
ELAC2 elaC ribonuclease Z 2 -2.47598
NUP62 nucleoporin 62kDa -2.45858
ZNF586 zinc finger protein 586 -2.43482
RIOX1 ribosomal oxygenase 1 -2.31503
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.26825
CDK1 cyclin-dependent kinase 1 -2.25585
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.25352
KEAP1 kelch-like ECH-associated protein 1 -2.25027
KIF13A kinesin family member 13A -2.22257
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) -2.19105
NISCH nischarin -2.18705
TXNDC9 thioredoxin domain containing 9 -2.18648
LOC124907782 dual specificity protein phosphatase 22 -2.12389
NGRN neugrin, neurite outgrowth associated -2.05279
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.0526
COG2 component of oligomeric golgi complex 2 -2.02474
NRIP1 nuclear receptor interacting protein 1 -2.02382
HMGN3 high mobility group nucleosomal binding domain 3 -2.01014
HHAT hedgehog acyltransferase -2.00416
CDC20 cell division cycle 20 -2.00154