CRCGN014_HEPG2_3H:M05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description barium chloride dihydrate 40.4 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN014_HEPG2_3H:M05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.6923
MAP7 microtubule-associated protein 7 4.59766
LCN2 lipocalin 2 3.74687
LPAR2 lysophosphatidic acid receptor 2 3.3983
BACE2 beta-site APP-cleaving enzyme 2 3.39527
CBR3 carbonyl reductase 3 3.38067
CHMP6 charged multivesicular body protein 6 3.30313
ADRB2 adrenoceptor beta 2, surface 3.18527
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.07183
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.06797
FZD7 frizzled class receptor 7 3.06243
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.83488
NOSIP nitric oxide synthase interacting protein 2.82553
CXCL2 chemokine (C-X-C motif) ligand 2 2.80437
EPHB2 EPH receptor B2 2.63348
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.61005
UBE2A ubiquitin-conjugating enzyme E2A 2.51952
UBQLN2 ubiquilin 2 2.4804
SNAP25 synaptosomal-associated protein, 25kDa 2.45917
MEST mesoderm specific transcript 2.4543
ATP11B ATPase, class VI, type 11B 2.39837
KIF20A kinesin family member 20A 2.36273
MCUR1 mitochondrial calcium uniporter regulator 1 2.31387
TLK2 tousled-like kinase 2 2.27995
SSBP2 single-stranded DNA binding protein 2 2.27545
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.1963
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 2.16893
TBP TATA box binding protein 2.16393
CHODL chondrolectin 2.13993
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.1384
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.0846
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.06637
TXNL4B thioredoxin-like 4B 2.0266

decreased expression

Symbol Name Standardized Value
CASP7 caspase 7, apoptosis-related cysteine peptidase -6.24703
SPAG4 sperm associated antigen 4 -3.8671
CCDC86 coiled-coil domain containing 86 -3.82167
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.73827
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.58173
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.352
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.33333
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.3331
PCNA proliferating cell nuclear antigen -3.23147
TMCO1 transmembrane and coiled-coil domains 1 -2.98994
LDHD lactate dehydrogenase D -2.94317
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.83967
CCNB1 cyclin B1 -2.76497
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.7233
MAPK13 mitogen-activated protein kinase 13 -2.61938
NGRN neugrin, neurite outgrowth associated -2.581
CDC20 cell division cycle 20 -2.5347
NT5DC2 5'-nucleotidase domain containing 2 -2.46863
CSK c-src tyrosine kinase -2.3886
TLCD3A TLC domain containing 3A -2.3759
CCNH cyclin H -2.33753
TXNDC9 thioredoxin domain containing 9 -2.30687
WDR7 WD repeat domain 7 -2.22383
SNX11 sorting nexin 11 -2.1437
GLOD4 glyoxalase domain containing 4 -2.13763
TCTN1 tectonic family member 1 -2.1124
MTA1 metastasis associated 1 -2.00077