| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | pyrazinamide 39.6 um perturbation at 3 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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56 genes differentially expressed following the CRCGN014_HEPG2_3H:M07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 9.23593 |
| PPARG | peroxisome proliferator-activated receptor gamma | 5.19192 |
| SKIC8 | SKI8 subunit of superkiller complex | 4.94117 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 4.74723 |
| E2F2 | E2F transcription factor 2 | 4.47787 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.41453 |
| CYCS | cytochrome c, somatic | 4.31366 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 4.31289 |
| CSK | c-src tyrosine kinase | 4.13882 |
| CHMP6 | charged multivesicular body protein 6 | 4.13524 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 4.09161 |
| LPAR2 | lysophosphatidic acid receptor 2 | 3.36831 |
| RRAGA | Ras-related GTP binding A | 3.17417 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 2.90942 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 2.64287 |
| EGF | epidermal growth factor | 2.55086 |
| ANO10 | anoctamin 10 | 2.52778 |
| BAMBI | BMP and activin membrane-bound inhibitor | 2.41 |
| COPS7A | COP9 signalosome subunit 7A | 2.33635 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.24987 |
| FRZB | frizzled-related protein | 2.23193 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.21931 |
| CORO1A | coronin, actin binding protein, 1A | 2.21487 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 2.06855 |
| ZWINT | ZW10 interacting kinetochore protein | 2.03949 |
| ZNF334 | zinc finger protein 334 | 2.01175 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ADI1 | acireductone dioxygenase 1 | -9.33991 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -7.4826 |
| DNM1L | dynamin 1-like | -5.3909 |
| LDHD | lactate dehydrogenase D | -5.20174 |
| VAT1 | vesicle amine transport 1 | -5.01415 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -4.84616 |
| KDM3A | lysine (K)-specific demethylase 3A | -4.57682 |
| TLR4 | toll-like receptor 4 | -4.53076 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -4.46747 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -4.15002 |
| DERA | deoxyribose-phosphate aldolase (putative) | -3.69856 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -3.65754 |
| TXNDC9 | thioredoxin domain containing 9 | -3.48607 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -3.37364 |
| ZNF586 | zinc finger protein 586 | -3.33006 |
| CD58 | CD58 molecule | -3.30704 |
| RHEB | Ras homolog enriched in brain | -3.25881 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -3.12917 |
| SPAG4 | sperm associated antigen 4 | -2.80328 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -2.66212 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -2.45592 |
| SYF2 | SYF2 pre-mRNA-splicing factor | -2.40337 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -2.38885 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -2.37686 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.31235 |
| PDS5A | PDS5 cohesin associated factor A | -2.27886 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -2.27809 |
| AKAP8 | A kinase (PRKA) anchor protein 8 | -2.15134 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.07805 |
| HEBP2 | heme binding protein 2 | -2.00375 |
