CRCGN014_HEPG2_3H:M08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description roxarsone 39.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN014_HEPG2_3H:M08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ANO1 anoctamin 1, calcium activated chloride channel 7.42489
PPARG peroxisome proliferator-activated receptor gamma 6.5433
ADGRE5 adhesion G protein-coupled receptor E5 5.99616
PNKP polynucleotide kinase 3'-phosphatase 4.08021
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.93598
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.86943
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.82721
GPATCH8 G patch domain containing 8 3.44516
ZNF589 zinc finger protein 589 3.19453
CHMP6 charged multivesicular body protein 6 3.13627
NUCB2 nucleobindin 2 3.10205
CIAO3 cytosolic iron-sulfur assembly component 3 2.93137
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.86224
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.82537
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.78702
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.77915
KDM5A lysine (K)-specific demethylase 5A 2.68337
ABHD6 abhydrolase domain containing 6 2.65347
GATA3 GATA binding protein 3 2.53189
FZD7 frizzled class receptor 7 2.45157
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.3752
PFKL phosphofructokinase, liver 2.34957
WDTC1 WD and tetratricopeptide repeats 1 2.226
GSTZ1 glutathione S-transferase zeta 1 2.16449
KIF14 kinesin family member 14 2.16397
CSK c-src tyrosine kinase 2.12029
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.10523
SCYL3 SCY1-like 3 (S. cerevisiae) 2.08919
MAST2 microtubule associated serine/threonine kinase 2 2.08338
SAMHD1 SAM domain and HD domain 1 2.05594

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -6.86293
PCNA proliferating cell nuclear antigen -6.84604
CCNB2 cyclin B2 -6.69272
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.83284
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.67902
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.13248
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.07214
KDM3A lysine (K)-specific demethylase 3A -2.9918
UGDH UDP-glucose 6-dehydrogenase -2.969
CD320 CD320 molecule -2.91967
CDC25B cell division cycle 25B -2.73115
STX4 syntaxin 4 -2.63397
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.63221
ADI1 acireductone dioxygenase 1 -2.51087
UBE3C ubiquitin protein ligase E3C -2.50475
FAIM Fas apoptotic inhibitory molecule -2.3594
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.00965