CRCGN014_HEPG2_3H:M10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-(4-ethoxyphenyl)urea 21.27 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

77 genes differentially expressed following the CRCGN014_HEPG2_3H:M10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 8.09529
UBQLN2 ubiquilin 2 6.0741
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.98547
PHKG2 phosphorylase kinase, gamma 2 (testis) 4.6811
TAC4 tachykinin 4 (hemokinin) 4.61595
BACE2 beta-site APP-cleaving enzyme 2 4.57249
MYLK myosin light chain kinase 4.51144
DYNLT3 dynein, light chain, Tctex-type 3 4.40376
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.17568
CXCL2 chemokine (C-X-C motif) ligand 2 4.12734
SIRT3 sirtuin 3 4.0995
ADGRE5 adhesion G protein-coupled receptor E5 3.9987
BZW2 basic leucine zipper and W2 domains 2 3.88209
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.84358
SNAP25 synaptosomal-associated protein, 25kDa 3.48109
CCNF cyclin F 3.28569
GATA3 GATA binding protein 3 3.19618
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.11497
CSK c-src tyrosine kinase 3.10674
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.09442
PFKL phosphofructokinase, liver 3.08296
CHN1 chimerin 1 3.04843
TIAM1 T-cell lymphoma invasion and metastasis 1 2.75309
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.67148
CYCS cytochrome c, somatic 2.66715
TUBB2B tubulin, beta 2B class IIb 2.53959
TSPAN6 tetraspanin 6 2.53738
MAP7 microtubule-associated protein 7 2.49896
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.38932
CPAP centrosome assembly and centriole elongation protein 2.38242
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.30899
NOSIP nitric oxide synthase interacting protein 2.30593
ADRB2 adrenoceptor beta 2, surface 2.29879
TEX10 testis expressed 10 2.24353
PXMP2 peroxisomal membrane protein 2, 22kDa 2.22367
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.14427
TTLL1 tubulin tyrosine ligase-like family member 1 2.12624
PRMT7 protein arginine methyltransferase 7 2.1208
GATD3 glutamine amidotransferase class 1 domain containing 3 2.11645
SSBP2 single-stranded DNA binding protein 2 2.09197
SMYD3 SET and MYND domain containing 3 2.04689
PMM2 phosphomannomutase 2 2.01026
NNAT neuronatin 2.00438

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -8.29717
CCNB2 cyclin B2 -7.43297
DSG2 desmoglein 2 -6.4373
OXA1L oxidase (cytochrome c) assembly 1-like -6.30023
PCNA proliferating cell nuclear antigen -4.81575
NCK1 NCK adaptor protein 1 -4.57613
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.2343
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.21717
CDC20 cell division cycle 20 -4.20628
KDM3A lysine (K)-specific demethylase 3A -3.88019
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.67199
TLR4 toll-like receptor 4 -3.6069
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.56918
YME1L1 YME1-like 1 ATPase -3.3194
CD58 CD58 molecule -3.16139
EXT1 exostosin glycosyltransferase 1 -3.01873
TRIB3 tribbles pseudokinase 3 -3.01434
GNAS GNAS complex locus -2.87584
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.81123
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.76382
PRPF4 pre-mRNA processing factor 4 -2.73203
FAIM Fas apoptotic inhibitory molecule -2.62231
WASHC4 WASH complex subunit 4 -2.43267
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -2.30544
MRPS2 mitochondrial ribosomal protein S2 -2.26725
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -2.22134
SH2B3 SH2B adaptor protein 3 -2.14567
GOLGA4 golgin A4 -2.14065
PPME1 protein phosphatase methylesterase 1 -2.13023
PRC1 protein regulator of cytokinesis 1 -2.12612
SLC35F2 solute carrier family 35, member F2 -2.11129
KDSR 3-ketodihydrosphingosine reductase -2.06606
HOOK1 hook microtubule-tethering protein 1 -2.05497
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 -2.00488