| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | vorinostat 10.0 um perturbation at 3 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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202 genes differentially expressed following the CRCGN014_HEPG2_3H:M14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PRKCD | protein kinase C, delta | 7.15534 |
| FOXO4 | forkhead box O4 | 7.01376 |
| TBPL1 | TBP-like 1 | 6.31578 |
| CCND3 | cyclin D3 | 6.31061 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 5.51601 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 5.45581 |
| ALDOC | aldolase C, fructose-bisphosphate | 5.34779 |
| CDK7 | cyclin-dependent kinase 7 | 5.13146 |
| PLA2G15 | phospholipase A2, group XV | 5.03697 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 4.89069 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 4.81907 |
| STX1A | syntaxin 1A (brain) | 4.73322 |
| TBC1D10C | TBC1 domain family, member 10C | 4.53117 |
| CORO1A | coronin, actin binding protein, 1A | 4.42997 |
| HSPA1A | heat shock 70kDa protein 1A | 4.34264 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 4.21191 |
| GLRX | glutaredoxin (thioltransferase) | 4.20379 |
| FZD7 | frizzled class receptor 7 | 4.19166 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 4.1477 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 4.11288 |
| TRAK2 | trafficking protein, kinesin binding 2 | 3.971 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 3.94296 |
| BLCAP | bladder cancer associated protein | 3.81312 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | 3.72295 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 3.56692 |
| CYCS | cytochrome c, somatic | 3.52669 |
| STK10 | serine/threonine kinase 10 | 3.51458 |
| MYLK | myosin light chain kinase | 3.47521 |
| EPHB2 | EPH receptor B2 | 3.47035 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 3.4158 |
| ICAM1 | intercellular adhesion molecule 1 | 3.28957 |
| MVP | major vault protein | 3.24017 |
| PLS1 | plastin 1 | 3.229 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 3.10964 |
| MCOLN1 | mucolipin 1 | 3.0791 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 2.96054 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 2.86427 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | 2.83814 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 2.82498 |
| HMG20B | high mobility group 20B | 2.81763 |
| HMOX1 | heme oxygenase 1 | 2.77007 |
| NDUFB3 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa | 2.75958 |
| SETD3 | SET domain containing 3 | 2.74174 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 2.73845 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 2.71905 |
| STXBP1 | syntaxin binding protein 1 | 2.70797 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 2.67129 |
| UBR7 | ubiquitin protein ligase E3 component n-recognin 7 (putative) | 2.66775 |
| ACOT8 | acyl-CoA thioesterase 8 | 2.65605 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.63182 |
| TMEM50A | transmembrane protein 50A | 2.61199 |
| LCN2 | lipocalin 2 | 2.56926 |
| IFT52 | intraflagellar transport 52 | 2.44208 |
| NCOA3 | nuclear receptor coactivator 3 | 2.3963 |
| GPN3 | GPN-loop GTPase 3 | 2.39193 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | 2.38341 |
| SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | 2.36781 |
| KCTD5 | potassium channel tetramerization domain containing 5 | 2.35981 |
| CMC2 | C-x(9)-C motif containing 2 | 2.35005 |
| NUP133 | nucleoporin 133kDa | 2.34812 |
| BAG3 | BCL2-associated athanogene 3 | 2.34416 |
| COG2 | component of oligomeric golgi complex 2 | 2.34362 |
| HSPA1B | heat shock 70kDa protein 1B | 2.34236 |
| ATG2A | autophagy related 2A | 2.33724 |
| PPP1CA | protein phosphatase 1, catalytic subunit, alpha isozyme | 2.30986 |
| APEH | acylaminoacyl-peptide hydrolase | 2.28832 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 2.28037 |
| SLC25A20 | solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 | 2.28034 |
| PDE6D | phosphodiesterase 6D, cGMP-specific, rod, delta | 2.27573 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | 2.26878 |
| HIBCH | 3-hydroxyisobutyryl-CoA hydrolase | 2.25007 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | 2.23157 |
| CTNNBL1 | catenin, beta like 1 | 2.22168 |
| WDR37 | WD repeat domain 37 | 2.21671 |
| USP4 | ubiquitin specific peptidase 4 (proto-oncogene) | 2.21005 |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | 2.20293 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 2.19052 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 2.1891 |
| ARFIP2 | ADP-ribosylation factor interacting protein 2 | 2.17011 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 2.1668 |
| SYNDIG1 | synapse differentiation inducing 1 | 2.1567 |
| YIPF1 | Yip1 domain family, member 1 | 2.15387 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 2.14288 |
| ROGDI | rogdi homolog (Drosophila) | 2.13858 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 2.13725 |
| TUBA4A | tubulin, alpha 4a | 2.13252 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 2.12981 |
| CYTH1 | cytohesin 1 | 2.12486 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 2.1229 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 2.12011 |
| PRPF18 | pre-mRNA processing factor 18 | 2.09408 |
| SEPTIN6 | septin 6 | 2.07516 |
| DUSP6 | dual specificity phosphatase 6 | 2.05619 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 2.05319 |
| STXBP2 | syntaxin binding protein 2 | 2.04797 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.04687 |
| TSG101 | tumor susceptibility 101 | 2.04594 |
| DNM1 | dynamin 1 | 2.03884 |
| MT1X | metallothionein 1X | 2.02306 |
| CHUK | conserved helix-loop-helix ubiquitous kinase | 2.02165 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ISOC1 | isochorismatase domain containing 1 | -8.1827 |
| KEAP1 | kelch-like ECH-associated protein 1 | -7.98846 |
| TCERG1 | transcription elongation regulator 1 | -7.65698 |
| SPAG4 | sperm associated antigen 4 | -6.8306 |
| CCNB2 | cyclin B2 | -6.6802 |
| CD320 | CD320 molecule | -6.60853 |
| CDC20 | cell division cycle 20 | -6.14428 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -6.04028 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -5.7634 |
| TLCD3A | TLC domain containing 3A | -5.65758 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -5.22765 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -4.74467 |
| DUSP11 | dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) | -4.31702 |
| ADI1 | acireductone dioxygenase 1 | -4.09637 |
| TSPAN4 | tetraspanin 4 | -4.02174 |
| FAIM | Fas apoptotic inhibitory molecule | -3.89307 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -3.88369 |
| TRIM13 | tripartite motif containing 13 | -3.68079 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -3.65659 |
| RRAGA | Ras-related GTP binding A | -3.36193 |
| CCNB1 | cyclin B1 | -3.30548 |
| SLC35F2 | solute carrier family 35, member F2 | -3.30429 |
| FOSL1 | FOS-like antigen 1 | -3.27268 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -3.26411 |
| MAPK1IP1L | mitogen-activated protein kinase 1 interacting protein 1-like | -3.1752 |
| TRIB3 | tribbles pseudokinase 3 | -3.16812 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -3.08235 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -3.07396 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -3.05664 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -2.97441 |
| FOXM1 | forkhead box M1 | -2.86523 |
| PRPF4 | pre-mRNA processing factor 4 | -2.79782 |
| IGHMBP2 | immunoglobulin mu binding protein 2 | -2.79306 |
| BIRC2 | baculoviral IAP repeat containing 2 | -2.79198 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.71929 |
| ESRP2 | epithelial splicing regulatory protein 2 | -2.70173 |
| QTRT1 | queuine tRNA-ribosyltransferase 1 | -2.68898 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -2.68252 |
| PARP2 | poly (ADP-ribose) polymerase 2 | -2.68149 |
| MAP3K4 | mitogen-activated protein kinase kinase kinase 4 | -2.67502 |
| LDHD | lactate dehydrogenase D | -2.64773 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -2.6472 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.64259 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -2.57276 |
| NSMAF | neutral sphingomyelinase (N-SMase) activation associated factor | -2.57225 |
| SMYD5 | SMYD family member 5 | -2.54335 |
| ARAF | A-Raf proto-oncogene, serine/threonine kinase | -2.53436 |
| VRK2 | vaccinia related kinase 2 | -2.49279 |
| CTCF | CCCTC-binding factor (zinc finger protein) | -2.44754 |
| CCNA2 | cyclin A2 | -2.44223 |
| TIMCC | TIM double twin CX3C motif chaperone | -2.43405 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -2.43241 |
| PGR | progesterone receptor | -2.42734 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | -2.4168 |
| TMEM39B | transmembrane protein 39B | -2.41268 |
| LRRC41 | leucine rich repeat containing 41 | -2.39791 |
| NUP62 | nucleoporin 62kDa | -2.39033 |
| CASC3 | cancer susceptibility candidate 3 | -2.37064 |
| TLR4 | toll-like receptor 4 | -2.36803 |
| MRPS2 | mitochondrial ribosomal protein S2 | -2.35464 |
| RAB11FIP2 | RAB11 family interacting protein 2 (class I) | -2.33978 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -2.32471 |
| GTPBP8 | GTP-binding protein 8 (putative) | -2.32078 |
| RDH14 | retinol dehydrogenase 14 (all-trans/9-cis/11-cis) | -2.31185 |
| MSH6 | mutS homolog 6 | -2.31131 |
| ALPL | alkaline phosphatase, liver/bone/kidney | -2.30773 |
| ZNF586 | zinc finger protein 586 | -2.30253 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -2.29702 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -2.29075 |
| UBQLN2 | ubiquilin 2 | -2.28889 |
| TMEM109 | transmembrane protein 109 | -2.28558 |
| LRRC61 | leucine rich repeat containing 61 | -2.28145 |
| USP22 | ubiquitin specific peptidase 22 | -2.27915 |
| TSKU | tsukushi, small leucine rich proteoglycan | -2.2679 |
| PAGR1 | PAXIP1 associated glutamate-rich protein 1 | -2.24683 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -2.23965 |
| SINHCAF | SIN3-HDAC complex associated factor | -2.2279 |
| MRM3 | mitochondrial rRNA methyltransferase 3 | -2.18835 |
| TRANK1 | tetratricopeptide repeat and ankyrin repeat containing 1 | -2.18713 |
| PHF2 | PHD finger protein 2 | -2.187 |
| TTC19 | tetratricopeptide repeat domain 19 | -2.17595 |
| CLIC2 | chloride intracellular channel 2 | -2.17061 |
| PES1 | pescadillo ribosomal biogenesis factor 1 | -2.16383 |
| ABCF1 | ATP-binding cassette, sub-family F (GCN20), member 1 | -2.15004 |
| MEPCE | methylphosphate capping enzyme | -2.14488 |
| STEAP3 | STEAP family member 3, metalloreductase | -2.1384 |
| TMEM260 | transmembrane protein 260 | -2.13096 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -2.12895 |
| ZXDA | zinc finger, X-linked, duplicated A | -2.11593 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -2.11188 |
| MRM1 | mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) | -2.0968 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | -2.09469 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -2.0677 |
| GEMIN4 | gem (nuclear organelle) associated protein 4 | -2.06281 |
| MICALL1 | MICAL-like 1 | -2.06122 |
| LOC124907782 | dual specificity protein phosphatase 22 | -2.03698 |
| UFM1 | ubiquitin-fold modifier 1 | -2.03697 |
| POGK | pogo transposable element with KRAB domain | -2.02547 |
| SDF4 | stromal cell derived factor 4 | -2.01552 |
| CCDC86 | coiled-coil domain containing 86 | -2.0126 |
| SMARCB1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | -2.00657 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.00103 |
