| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | vorinostat 5.0 um perturbation at 3 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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276 genes differentially expressed following the CRCGN014_HEPG2_3H:M15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CBR3 | carbonyl reductase 3 | 7.13813 |
| FOXO4 | forkhead box O4 | 6.64588 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 6.62309 |
| PRKCD | protein kinase C, delta | 6.17 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 5.92674 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 5.83027 |
| HSPA1A | heat shock 70kDa protein 1A | 5.66125 |
| PLA2G15 | phospholipase A2, group XV | 5.62548 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 5.53531 |
| CCND3 | cyclin D3 | 5.46392 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 5.08712 |
| STXBP1 | syntaxin binding protein 1 | 4.91271 |
| STX1A | syntaxin 1A (brain) | 4.85959 |
| CORO1A | coronin, actin binding protein, 1A | 4.84595 |
| CDK7 | cyclin-dependent kinase 7 | 4.74115 |
| BLCAP | bladder cancer associated protein | 4.57552 |
| TBC1D10C | TBC1 domain family, member 10C | 4.38673 |
| STIMATE | STIM activating enhancer | 4.36372 |
| LSR | lipolysis stimulated lipoprotein receptor | 4.28015 |
| ALDOC | aldolase C, fructose-bisphosphate | 4.20663 |
| TRAK2 | trafficking protein, kinesin binding 2 | 4.15368 |
| TBPL1 | TBP-like 1 | 4.06901 |
| AMDHD2 | amidohydrolase domain containing 2 | 3.80792 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 3.75415 |
| BAG3 | BCL2-associated athanogene 3 | 3.69632 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 3.66501 |
| MCOLN1 | mucolipin 1 | 3.65361 |
| RPL39L | ribosomal protein L39-like | 3.59633 |
| NUP133 | nucleoporin 133kDa | 3.5212 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | 3.49443 |
| GLRX | glutaredoxin (thioltransferase) | 3.44002 |
| SKIC8 | SKI8 subunit of superkiller complex | 3.43515 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | 3.41137 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 3.38941 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | 3.31975 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 3.27486 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.16035 |
| ICAM1 | intercellular adhesion molecule 1 | 3.11831 |
| CDKN2D | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 3.09427 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 3.07414 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.05632 |
| PHKG2 | phosphorylase kinase, gamma 2 (testis) | 3.04607 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 2.97784 |
| PPY | pancreatic polypeptide | 2.97269 |
| ATG2A | autophagy related 2A | 2.95561 |
| E2F2 | E2F transcription factor 2 | 2.93722 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.91547 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 2.90546 |
| FKBP14 | FK506 binding protein 14, 22 kDa | 2.87842 |
| DDIT4 | DNA-damage-inducible transcript 4 | 2.85008 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 2.84707 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 2.818 |
| RND1 | Rho family GTPase 1 | 2.79833 |
| STX5 | syntaxin 5 | 2.79216 |
| UBE2A | ubiquitin-conjugating enzyme E2A | 2.75748 |
| PDSS2 | prenyl (decaprenyl) diphosphate synthase, subunit 2 | 2.75736 |
| ATP11B | ATPase, class VI, type 11B | 2.75194 |
| SLC25A44 | solute carrier family 25, member 44 | 2.68795 |
| MYLK | myosin light chain kinase | 2.68063 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.65811 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 2.59678 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 2.57765 |
| FZD7 | frizzled class receptor 7 | 2.55754 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 2.5447 |
| PPARD | peroxisome proliferator-activated receptor delta | 2.53247 |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | 2.52332 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 2.50373 |
| STUM | stum, mechanosensory transduction mediator homolog | 2.47202 |
| TCEA2 | transcription elongation factor A (SII), 2 | 2.46957 |
| ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 2.46382 |
| PNKP | polynucleotide kinase 3'-phosphatase | 2.44269 |
| SOBP | sine oculis binding protein homolog (Drosophila) | 2.43371 |
| SETD3 | SET domain containing 3 | 2.43163 |
| KIF2C | kinesin family member 2C | 2.38625 |
| COPS7B | COP9 signalosome subunit 7B | 2.38555 |
| CYTH1 | cytohesin 1 | 2.38181 |
| DNM1 | dynamin 1 | 2.37095 |
| EPN2 | epsin 2 | 2.37007 |
| CDK19 | cyclin-dependent kinase 19 | 2.36554 |
| MEGF8 | multiple EGF-like-domains 8 | 2.36409 |
| PRPF38B | pre-mRNA processing factor 38B | 2.34406 |
| OSTF1 | osteoclast stimulating factor 1 | 2.34175 |
| HMOX1 | heme oxygenase 1 | 2.33932 |
| MSH5 | mutS homolog 5 | 2.33165 |
| SEC61A2 | Sec61 alpha 2 subunit (S. cerevisiae) | 2.33133 |
| HSPA1B | heat shock 70kDa protein 1B | 2.32885 |
| MVP | major vault protein | 2.32189 |
| PPP1R16B | protein phosphatase 1, regulatory subunit 16B | 2.3198 |
| ARFIP2 | ADP-ribosylation factor interacting protein 2 | 2.30184 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 2.29756 |
| DZANK1 | double zinc ribbon and ankyrin repeat domains 1 | 2.29493 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | 2.27842 |
| IDH3A | isocitrate dehydrogenase 3 (NAD+) alpha | 2.2736 |
| HIBCH | 3-hydroxyisobutyryl-CoA hydrolase | 2.26615 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 2.25694 |
| GTF2A2 | general transcription factor IIA, 2, 12kDa | 2.2531 |
| PCOLCE2 | procollagen C-endopeptidase enhancer 2 | 2.21063 |
| NAGA | N-acetylgalactosaminidase, alpha- | 2.19489 |
| VASH1 | vasohibin 1 | 2.19399 |
| PDE6D | phosphodiesterase 6D, cGMP-specific, rod, delta | 2.19002 |
| NOSIP | nitric oxide synthase interacting protein | 2.17583 |
| CENPB | centromere protein B, 80kDa | 2.1651 |
| OPLAH | 5-oxoprolinase (ATP-hydrolysing) | 2.16381 |
| TRPM4 | transient receptor potential cation channel, subfamily M, member 4 | 2.16109 |
| CCNF | cyclin F | 2.15477 |
| MEF2D | myocyte enhancer factor 2D | 2.14883 |
| HCK | HCK proto-oncogene, Src family tyrosine kinase | 2.14801 |
| IFT52 | intraflagellar transport 52 | 2.14099 |
| SNIP1 | Smad nuclear interacting protein 1 | 2.13695 |
| ICAM5 | intercellular adhesion molecule 5, telencephalin | 2.13652 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | 2.13293 |
| ARL3 | ADP-ribosylation factor-like 3 | 2.1163 |
| UBTD1 | ubiquitin domain containing 1 | 2.11483 |
| DUSP6 | dual specificity phosphatase 6 | 2.11389 |
| GOLGA7 | golgin A7 | 2.11386 |
| RNF5 | ring finger protein 5, E3 ubiquitin protein ligase | 2.11297 |
| ERCC2 | excision repair cross-complementation group 2 | 2.10197 |
| ACOT8 | acyl-CoA thioesterase 8 | 2.09885 |
| GPR137B | G protein-coupled receptor 137B | 2.09812 |
| STXBP2 | syntaxin binding protein 2 | 2.09198 |
| AMN | amnion associated transmembrane protein | 2.08671 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 2.08034 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 2.07901 |
| PHYHIP | phytanoyl-CoA 2-hydroxylase interacting protein | 2.06754 |
| CLDN3 | claudin 3 | 2.06668 |
| FAM168B | family with sequence similarity 168, member B | 2.06646 |
| RUBCN | rubicon autophagy regulator | 2.06626 |
| PSMD13 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 | 2.06391 |
| STEEP1 | STING1 ER exit protein 1 | 2.0611 |
| COMMD9 | COMM domain containing 9 | 2.05943 |
| CORO7-PAM16 | CORO7-PAM16 readthrough | 2.05356 |
| VPS9D1 | VPS9 domain containing 1 | 2.0481 |
| FCHO1 | FCH domain only 1 | 2.03933 |
| FAM131B | family with sequence similarity 131, member B | 2.03681 |
| ACOT7 | acyl-CoA thioesterase 7 | 2.03607 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 2.02613 |
| CRNN | cornulin | 2.02274 |
| SLC9A8 | solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 | 2.00718 |
| TPPP | tubulin polymerization promoting protein | 2.0067 |
| CAB39 | calcium binding protein 39 | 2.00436 |
| MMP23B | matrix metallopeptidase 23B | 2.00403 |
| CYP46A1 | cytochrome P450, family 46, subfamily A, polypeptide 1 | 2.0027 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KEAP1 | kelch-like ECH-associated protein 1 | -8.28064 |
| CD320 | CD320 molecule | -7.27384 |
| ISOC1 | isochorismatase domain containing 1 | -6.66219 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -6.17929 |
| SPAG4 | sperm associated antigen 4 | -6.16525 |
| TCERG1 | transcription elongation regulator 1 | -6.10366 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | -5.7449 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -4.51835 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -4.21721 |
| SCAND1 | SCAN domain containing 1 | -3.99281 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -3.93584 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -3.83184 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -3.7484 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -3.70061 |
| TRIB3 | tribbles pseudokinase 3 | -3.66138 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -3.63399 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | -3.59704 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.56214 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -3.49412 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.46153 |
| FOSL1 | FOS-like antigen 1 | -3.42234 |
| TRIM13 | tripartite motif containing 13 | -3.40062 |
| DNM1L | dynamin 1-like | -3.38257 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -3.33672 |
| PCNA | proliferating cell nuclear antigen | -3.25618 |
| CTCF | CCCTC-binding factor (zinc finger protein) | -3.23287 |
| GTPBP8 | GTP-binding protein 8 (putative) | -3.17433 |
| BIRC2 | baculoviral IAP repeat containing 2 | -3.14815 |
| AP1M2 | adaptor-related protein complex 1, mu 2 subunit | -3.09034 |
| MRPS7 | mitochondrial ribosomal protein S7 | -3.08709 |
| TLCD3A | TLC domain containing 3A | -2.99088 |
| MRPL58 | mitochondrial ribosomal protein L58 | -2.98209 |
| MAPK1IP1L | mitogen-activated protein kinase 1 interacting protein 1-like | -2.93691 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | -2.90758 |
| CCNB1 | cyclin B1 | -2.88431 |
| CLASRP | CLK4-associating serine/arginine rich protein | -2.85393 |
| MRPS2 | mitochondrial ribosomal protein S2 | -2.84757 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.83976 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -2.82313 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.82085 |
| NUP85 | nucleoporin 85kDa | -2.68455 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | -2.66808 |
| MRTO4 | mRNA turnover 4 homolog (S. cerevisiae) | -2.65651 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -2.65614 |
| MAK16 | MAK16 homolog (S. cerevisiae) | -2.60708 |
| ADNP | activity-dependent neuroprotector homeobox | -2.60525 |
| NOL11 | nucleolar protein 11 | -2.60137 |
| EXOSC8 | exosome component 8 | -2.59932 |
| BYSL | bystin-like | -2.57314 |
| ABCF1 | ATP-binding cassette, sub-family F (GCN20), member 1 | -2.56943 |
| SRMS | src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites | -2.54243 |
| VAT1 | vesicle amine transport 1 | -2.54044 |
| NUP62 | nucleoporin 62kDa | -2.50497 |
| RAB11FIP2 | RAB11 family interacting protein 2 (class I) | -2.47056 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -2.45944 |
| UFM1 | ubiquitin-fold modifier 1 | -2.4491 |
| NUDT15 | nudix (nucleoside diphosphate linked moiety X)-type motif 15 | -2.44195 |
| MED17 | mediator complex subunit 17 | -2.43334 |
| WASHC4 | WASH complex subunit 4 | -2.43191 |
| AXIN1 | axin 1 | -2.4264 |
| NAT9 | N-acetyltransferase 9 (GCN5-related, putative) | -2.40916 |
| PPP1R8 | protein phosphatase 1, regulatory subunit 8 | -2.39603 |
| CUL1 | cullin 1 | -2.39566 |
| PRPF4 | pre-mRNA processing factor 4 | -2.38366 |
| KCNE2 | potassium channel, voltage gated subfamily E regulatory beta subunit 2 | -2.3793 |
| FBL | fibrillarin | -2.37694 |
| CCDC86 | coiled-coil domain containing 86 | -2.36814 |
| PAGR1 | PAXIP1 associated glutamate-rich protein 1 | -2.36748 |
| YAP1 | Yes-associated protein 1 | -2.35975 |
| THAP7 | THAP domain containing 7 | -2.35267 |
| TIMCC | TIM double twin CX3C motif chaperone | -2.34741 |
| MRPL34 | mitochondrial ribosomal protein L34 | -2.32307 |
| CLDN1 | claudin 1 | -2.32296 |
| ECD | ecdysoneless homolog (Drosophila) | -2.31963 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.3178 |
| PARP2 | poly (ADP-ribose) polymerase 2 | -2.31015 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -2.29914 |
| KLF3 | Kruppel-like factor 3 (basic) | -2.29451 |
| DDX23 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 | -2.27803 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -2.2753 |
| BMP4 | bone morphogenetic protein 4 | -2.27231 |
| DHX32 | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | -2.2721 |
| PUM1 | pumilio RNA-binding family member 1 | -2.26931 |
| DDX39A | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A | -2.26073 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -2.25679 |
| VRK2 | vaccinia related kinase 2 | -2.21693 |
| PPRC1 | peroxisome proliferator-activated receptor gamma, coactivator-related 1 | -2.20916 |
| PUF60 | poly-U binding splicing factor 60KDa | -2.20766 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -2.20552 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -2.20006 |
| TMEM106B | transmembrane protein 106B | -2.19862 |
| CENPX | centromere protein X | -2.19727 |
| YARS2 | tyrosyl-tRNA synthetase 2, mitochondrial | -2.19336 |
| SLC35F2 | solute carrier family 35, member F2 | -2.18552 |
| MSH6 | mutS homolog 6 | -2.17991 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -2.17855 |
| NIPAL2 | NIPA-like domain containing 2 | -2.17338 |
| GSAP | gamma-secretase activating protein | -2.17195 |
| SMYD5 | SMYD family member 5 | -2.1719 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -2.17177 |
| DHX30 | DEAH (Asp-Glu-Ala-His) box helicase 30 | -2.16897 |
| RCC1L | RCC1 like | -2.15668 |
| SPAG7 | sperm associated antigen 7 | -2.15339 |
| NXT1 | nuclear transport factor 2-like export factor 1 | -2.14484 |
| STK25 | serine/threonine kinase 25 | -2.13174 |
| SUMO4 | small ubiquitin-like modifier 4 | -2.11554 |
| QTRT1 | queuine tRNA-ribosyltransferase 1 | -2.11427 |
| STEAP3 | STEAP family member 3, metalloreductase | -2.11245 |
| EMG1 | EMG1 N1-specific pseudouridine methyltransferase | -2.10539 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -2.10321 |
| YTHDF2 | YTH N(6)-methyladenosine RNA binding protein 2 | -2.10234 |
| CPSF4 | cleavage and polyadenylation specific factor 4, 30kDa | -2.09689 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | -2.09682 |
| ARHGEF5 | Rho guanine nucleotide exchange factor (GEF) 5 | -2.09274 |
| AUP1 | ancient ubiquitous protein 1 | -2.09131 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | -2.08879 |
| IGHMBP2 | immunoglobulin mu binding protein 2 | -2.08028 |
| MAP3K4 | mitogen-activated protein kinase kinase kinase 4 | -2.07671 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -2.07178 |
| USP22 | ubiquitin specific peptidase 22 | -2.0663 |
| COMMD10 | COMM domain containing 10 | -2.06424 |
| NEK3 | NIMA-related kinase 3 | -2.05975 |
| IFRD2 | interferon-related developmental regulator 2 | -2.05534 |
| ALG5 | ALG5, dolichyl-phosphate beta-glucosyltransferase | -2.05081 |
| PES1 | pescadillo ribosomal biogenesis factor 1 | -2.04295 |
| CASC3 | cancer susceptibility candidate 3 | -2.04036 |
| CCNA2 | cyclin A2 | -2.03788 |
| CDK6 | cyclin-dependent kinase 6 | -2.03353 |
| CARS2 | cysteinyl-tRNA synthetase 2, mitochondrial (putative) | -2.0306 |
| PHIP | pleckstrin homology domain interacting protein | -2.0283 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -2.02426 |
| RBM6 | RNA binding motif protein 6 | -2.02014 |
| DCLRE1A | DNA cross-link repair 1A | -2.01937 |
| UMPS | uridine monophosphate synthetase | -2.01664 |
