CRCGN014_HEPG2_3H:M17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-ddt 40.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

105 genes differentially expressed following the CRCGN014_HEPG2_3H:M17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 10.0
IER3 immediate early response 3 8.08939
EGR1 early growth response 1 7.65522
FOSL1 FOS-like antigen 1 6.16131
CNPY3 canopy FGF signaling regulator 3 5.76307
TRIB1 tribbles pseudokinase 1 5.74491
MAP7 microtubule-associated protein 7 5.65982
MYC v-myc avian myelocytomatosis viral oncogene homolog 5.33997
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4.72698
JUN jun proto-oncogene 4.70301
LOC102724023 ES1 protein homolog, mitochondrial 4.52671
ZFP36 ZFP36 ring finger protein 4.49514
FOS FBJ murine osteosarcoma viral oncogene homolog 4.37619
PPARG peroxisome proliferator-activated receptor gamma 4.2891
DUSP6 dual specificity phosphatase 6 4.28751
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 4.26313
CXCL2 chemokine (C-X-C motif) ligand 2 4.10285
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.92354
UBQLN2 ubiquilin 2 3.80992
IER2 immediate early response 2 3.69803
NOTCH1 notch 1 3.66377
GPER1 G protein-coupled estrogen receptor 1 3.59553
TRIB3 tribbles pseudokinase 3 3.56191
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 3.53773
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.46782
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.4424
PNKP polynucleotide kinase 3'-phosphatase 3.41329
CBR3 carbonyl reductase 3 3.35879
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.21749
HOXA10 homeobox A10 3.18168
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.14221
GADD45B growth arrest and DNA-damage-inducible, beta 3.05219
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.0516
RFC2 replication factor C (activator 1) 2, 40kDa 2.9062
EDN1 endothelin 1 2.88734
ICAM1 intercellular adhesion molecule 1 2.88278
KLHL21 kelch-like family member 21 2.81496
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.79569
CSK c-src tyrosine kinase 2.77125
ADRB2 adrenoceptor beta 2, surface 2.76353
BHLHE40 basic helix-loop-helix family, member e40 2.73721
NPDC1 neural proliferation, differentiation and control, 1 2.72349
FOXJ3 forkhead box J3 2.71613
GOLT1B golgi transport 1B 2.6952
EGR3 early growth response 3 2.56766
ATF3 activating transcription factor 3 2.51083
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.50108
LPAR2 lysophosphatidic acid receptor 2 2.35079
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.34841
HSPA1A heat shock 70kDa protein 1A 2.29774
SFTPB surfactant protein B 2.27408
HCLS1 hematopoietic cell-specific Lyn substrate 1 2.27088
LOC127933115 uncharacterized LOC127933115 2.23883
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.23243
HBEGF heparin-binding EGF-like growth factor 2.22078
PELI1 pellino E3 ubiquitin protein ligase 1 2.21126
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.20894
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing 2.20868
ADAP2 ArfGAP with dual PH domains 2 2.2002
NFE2L2 nuclear factor, erythroid 2-like 2 2.17387
CCNE2 cyclin E2 2.14914
PHLDA2 pleckstrin homology-like domain, family A, member 2 2.11786
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.11322
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.08838
KLF7 Kruppel-like factor 7 (ubiquitous) 2.08811
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.08551
NR4A1 nuclear receptor subfamily 4, group A, member 1 2.04235
RSF1 remodeling and spacing factor 1 2.0316

decreased expression

Symbol Name Standardized Value
CDC25B cell division cycle 25B -6.02483
CDC20 cell division cycle 20 -5.46162
BLCAP bladder cancer associated protein -5.04792
PCCB propionyl CoA carboxylase, beta polypeptide -4.92645
GRWD1 glutamate-rich WD repeat containing 1 -4.51007
UGDH UDP-glucose 6-dehydrogenase -4.38999
TLCD3A TLC domain containing 3A -4.35327
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -4.1582
GET1 guided entry of tail-anchored proteins factor 1 -4.04204
PSRC1 proline/serine-rich coiled-coil 1 -4.00675
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.75853
WDR7 WD repeat domain 7 -3.59289
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.46389
MPC2 mitochondrial pyruvate carrier 2 -3.42041
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.28256
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.27325
ZNF586 zinc finger protein 586 -3.18608
DNM1L dynamin 1-like -3.14692
PARP2 poly (ADP-ribose) polymerase 2 -3.13613
CCNB2 cyclin B2 -3.08585
TM9SF3 transmembrane 9 superfamily member 3 -2.77504
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.70157
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa -2.43968
GNAS GNAS complex locus -2.32574
HMOX1 heme oxygenase 1 -2.31421
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.26528
TXLNA taxilin alpha -2.26239
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.13296
NT5DC2 5'-nucleotidase domain containing 2 -2.12824
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.11877
DPH2 DPH2 homolog (S. cerevisiae) -2.1181
MOGS mannosyl-oligosaccharide glucosidase -2.10762
ICAM3 intercellular adhesion molecule 3 -2.09579
ETFB electron-transfer-flavoprotein, beta polypeptide -2.08529
PAGR1 PAXIP1 associated glutamate-rich protein 1 -2.0744
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -2.05143
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta -2.04112