CRCGN014_HEPG2_3H:M19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzyl-alcohol 39.6 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN014_HEPG2_3H:M19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 8.52819
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.75441
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.47885
BZW2 basic leucine zipper and W2 domains 2 4.5435
CBR3 carbonyl reductase 3 4.51918
CSK c-src tyrosine kinase 4.47094
RPP38 ribonuclease P/MRP 38kDa subunit 4.40761
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 4.3934
CARMIL1 capping protein regulator and myosin 1 linker 1 4.35339
PNKP polynucleotide kinase 3'-phosphatase 4.15811
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 4.00842
PPARG peroxisome proliferator-activated receptor gamma 3.97827
CYCS cytochrome c, somatic 3.93442
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.86967
DYNLT3 dynein, light chain, Tctex-type 3 3.85087
PEX11A peroxisomal biogenesis factor 11 alpha 3.43369
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 3.18781
HPRT1 hypoxanthine phosphoribosyltransferase 1 3.1615
CHMP6 charged multivesicular body protein 6 3.03
HYOU1 hypoxia up-regulated 1 2.88731
CCNF cyclin F 2.85971
CHEK2 checkpoint kinase 2 2.71765
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.5709
AXIN1 axin 1 2.47458
SATB1 SATB homeobox 1 2.39955
TEX10 testis expressed 10 2.34086
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.28478
CORO1A coronin, actin binding protein, 1A 2.27436
TBP TATA box binding protein 2.25199
TIAM1 T-cell lymphoma invasion and metastasis 1 2.21582
NOTCH1 notch 1 2.12067
DIPK1A divergent protein kinase domain 1A 2.10859
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 2.10047
USP6NL USP6 N-terminal like 2.09955

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -7.03063
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.52722
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.1686
LDHD lactate dehydrogenase D -4.1485
MRPS2 mitochondrial ribosomal protein S2 -4.12767
NT5DC2 5'-nucleotidase domain containing 2 -3.88956
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.7463
TLR4 toll-like receptor 4 -3.74148
FGFR4 fibroblast growth factor receptor 4 -3.5756
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.46231
PLK1 polo-like kinase 1 -3.45033
ZMIZ1 zinc finger, MIZ-type containing 1 -3.38445
GNAS GNAS complex locus -3.25402
GRWD1 glutamate-rich WD repeat containing 1 -3.19066
TES testin LIM domain protein -2.81426
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.74119
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.59839
AURKB aurora kinase B -2.52337
CCNH cyclin H -2.50409
STAT1 signal transducer and activator of transcription 1, 91kDa -2.49367
NRIP1 nuclear receptor interacting protein 1 -2.46605
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.37396
TRIM66 tripartite motif containing 66 -2.27914
ANKRD10 ankyrin repeat domain 10 -2.22804
DACT1 dishevelled-binding antagonist of beta-catenin 1 -2.21276
SMC4 structural maintenance of chromosomes 4 -2.08896
LGMN legumain -2.0144
RNF40 ring finger protein 40, E3 ubiquitin protein ligase -2.01019
NUSAP1 nucleolar and spindle associated protein 1 -2.00123