CRCGN014_HEPG2_3H:M20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description iodoform 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

71 genes differentially expressed following the CRCGN014_HEPG2_3H:M20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.08881
JADE2 jade family PHD finger 2 3.92596
CHN1 chimerin 1 3.88964
E2F2 E2F transcription factor 2 3.82266
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.76984
UBQLN2 ubiquilin 2 3.73624
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.5855
ANO1 anoctamin 1, calcium activated chloride channel 3.51872
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.49567
NOTCH1 notch 1 3.47437
KIF14 kinesin family member 14 3.46121
RAP1GAP RAP1 GTPase activating protein 3.41599
CSK c-src tyrosine kinase 3.13092
CXCR4 chemokine (C-X-C motif) receptor 4 2.99515
STXBP2 syntaxin binding protein 2 2.9865
STIMATE STIM activating enhancer 2.82089
CCNA1 cyclin A1 2.68505
CCL2 chemokine (C-C motif) ligand 2 2.51087
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.4739
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.4105
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.38524
GPER1 G protein-coupled estrogen receptor 1 2.35812
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.35519
CRYZ crystallin, zeta (quinone reductase) 2.32176
SNAP25 synaptosomal-associated protein, 25kDa 2.26104
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.25211
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.24594
GPM6B glycoprotein M6B 2.19975
CXCL2 chemokine (C-X-C motif) ligand 2 2.16624
CCDC86 coiled-coil domain containing 86 2.13504
ZNF589 zinc finger protein 589 2.13336
SLC30A1 solute carrier family 30 (zinc transporter), member 1 2.11784
USP6NL USP6 N-terminal like 2.11293
CST1 cystatin SN 2.10905
GPATCH8 G patch domain containing 8 2.084
BATF basic leucine zipper transcription factor, ATF-like 2.04802
SPDEF SAM pointed domain containing ETS transcription factor 2.04445
KIF20A kinesin family member 20A 2.04414
NPTN neuroplastin 2.0245
RAB9A RAB9A, member RAS oncogene family 2.01271

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.03417
OXA1L oxidase (cytochrome c) assembly 1-like -6.46534
CASP7 caspase 7, apoptosis-related cysteine peptidase -6.11999
TLR4 toll-like receptor 4 -5.90866
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.84787
FAIM Fas apoptotic inhibitory molecule -3.53676
VAT1 vesicle amine transport 1 -3.49433
PCNA proliferating cell nuclear antigen -3.21277
PEG10 paternally expressed 10 -3.01044
ZMIZ1 zinc finger, MIZ-type containing 1 -2.98564
FHL2 four and a half LIM domains 2 -2.97391
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.79383
CD320 CD320 molecule -2.67838
HSPA8 heat shock 70kDa protein 8 -2.61273
COG7 component of oligomeric golgi complex 7 -2.55698
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.49283
BLCAP bladder cancer associated protein -2.45498
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.353
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) -2.33155
KERA keratocan -2.29082
RNASE6 ribonuclease, RNase A family, k6 -2.27636
ADAM15 ADAM metallopeptidase domain 15 -2.23495
CTSD cathepsin D -2.1551
SPAG6 sperm associated antigen 6 -2.14965
HMOX1 heme oxygenase 1 -2.13339
GNAS GNAS complex locus -2.13049
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -2.03813
KLF4 Kruppel-like factor 4 (gut) -2.03051
SNTA1 syntrophin, alpha 1 -2.0213
TMEM209 transmembrane protein 209 -2.01176
CCNB1 cyclin B1 -2.01116