CRCGN014_HEPG2_3H:M22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ditiocarb-sodium-trihydrate 39.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN014_HEPG2_3H:M22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 5.7642
KIFBP kinesin family binding protein 4.92526
ANO1 anoctamin 1, calcium activated chloride channel 4.55387
TXNRD1 thioredoxin reductase 1 4.33215
USP6NL USP6 N-terminal like 4.239
GPER1 G protein-coupled estrogen receptor 1 3.67818
CSK c-src tyrosine kinase 3.67508
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.47785
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.23087
ABHD4 abhydrolase domain containing 4 3.21912
CXCL2 chemokine (C-X-C motif) ligand 2 3.13363
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.1011
HMOX1 heme oxygenase 1 3.09316
CIAO3 cytosolic iron-sulfur assembly component 3 2.95916
PLSCR3 phospholipid scramblase 3 2.84852
DIPK1A divergent protein kinase domain 1A 2.62028
TIAM1 T-cell lymphoma invasion and metastasis 1 2.525
KEAP1 kelch-like ECH-associated protein 1 2.35774
UGDH UDP-glucose 6-dehydrogenase 2.35551
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.15065
ADGRE5 adhesion G protein-coupled receptor E5 2.08504
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 2.07042
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.05459
CNRIP1 cannabinoid receptor interacting protein 1 2.01383

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -4.32574
CCNB2 cyclin B2 -3.23231
CDC20 cell division cycle 20 -3.00735
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.99395
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.94402
TXNDC9 thioredoxin domain containing 9 -2.45765
LOC124907782 dual specificity protein phosphatase 22 -2.21478
TAC3 tachykinin 3 -2.10919