| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | vorinostat 2.5 um perturbation at 3 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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225 genes differentially expressed following the CRCGN014_HEPG2_3H:M23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CGRRF1 | cell growth regulator with ring finger domain 1 | 7.08713 |
| TBPL1 | TBP-like 1 | 7.05322 |
| PRKCD | protein kinase C, delta | 6.93442 |
| CHMP6 | charged multivesicular body protein 6 | 6.8708 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 6.84944 |
| FOXO4 | forkhead box O4 | 6.7763 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 6.64637 |
| CCND3 | cyclin D3 | 5.99767 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 5.65683 |
| HSPA1A | heat shock 70kDa protein 1A | 5.57175 |
| MAP7 | microtubule-associated protein 7 | 5.41816 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 5.26064 |
| PLA2G15 | phospholipase A2, group XV | 5.20355 |
| CDK7 | cyclin-dependent kinase 7 | 5.05417 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 4.56248 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 4.54494 |
| ALDOC | aldolase C, fructose-bisphosphate | 4.54036 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 4.49187 |
| USP6NL | USP6 N-terminal like | 4.48578 |
| GLRX | glutaredoxin (thioltransferase) | 4.42095 |
| BAX | BCL2-associated X protein | 4.33889 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 4.24837 |
| DIPK1A | divergent protein kinase domain 1A | 3.87676 |
| STX1A | syntaxin 1A (brain) | 3.75388 |
| CEBPZ | CCAAT/enhancer binding protein (C/EBP), zeta | 3.70764 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 3.49978 |
| BLCAP | bladder cancer associated protein | 3.49794 |
| TRAK2 | trafficking protein, kinesin binding 2 | 3.39816 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 3.37309 |
| CDC25B | cell division cycle 25B | 3.36869 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.35462 |
| BAG3 | BCL2-associated athanogene 3 | 3.35181 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 3.28563 |
| RND1 | Rho family GTPase 1 | 3.22875 |
| TCEA2 | transcription elongation factor A (SII), 2 | 3.21925 |
| CORO1A | coronin, actin binding protein, 1A | 3.15162 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.11872 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 3.08549 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | 3.02256 |
| CHUK | conserved helix-loop-helix ubiquitous kinase | 2.94914 |
| TXNL4B | thioredoxin-like 4B | 2.81319 |
| MCOLN1 | mucolipin 1 | 2.79211 |
| MVP | major vault protein | 2.77378 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | 2.74459 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 2.7305 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | 2.70141 |
| ICAM1 | intercellular adhesion molecule 1 | 2.70048 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 2.66606 |
| UBE2A | ubiquitin-conjugating enzyme E2A | 2.61395 |
| NCOA3 | nuclear receptor coactivator 3 | 2.5796 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | 2.5551 |
| LIMA1 | LIM domain and actin binding 1 | 2.53957 |
| LBR | lamin B receptor | 2.47193 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 2.42333 |
| ARFIP2 | ADP-ribosylation factor interacting protein 2 | 2.40899 |
| EPHA3 | EPH receptor A3 | 2.4012 |
| CYP21A2 | cytochrome P450, family 21, subfamily A, polypeptide 2 | 2.38132 |
| HMG20B | high mobility group 20B | 2.37854 |
| GPR137B | G protein-coupled receptor 137B | 2.37518 |
| PLS1 | plastin 1 | 2.37075 |
| CYTH1 | cytohesin 1 | 2.36496 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 2.36484 |
| ACOT8 | acyl-CoA thioesterase 8 | 2.35153 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 2.34383 |
| ASTN1 | astrotactin 1 | 2.30658 |
| DMAP1 | DNA methyltransferase 1 associated protein 1 | 2.28706 |
| YPEL5 | yippee-like 5 (Drosophila) | 2.2698 |
| HPS5 | Hermansky-Pudlak syndrome 5 | 2.26472 |
| ROGDI | rogdi homolog (Drosophila) | 2.25458 |
| TMEM50A | transmembrane protein 50A | 2.24881 |
| DEF8 | differentially expressed in FDCP 8 homolog (mouse) | 2.23788 |
| PSRC1 | proline/serine-rich coiled-coil 1 | 2.23511 |
| PPY | pancreatic polypeptide | 2.22908 |
| HSPA1B | heat shock 70kDa protein 1B | 2.22235 |
| LOC127933115 | uncharacterized LOC127933115 | 2.21878 |
| AVPI1 | arginine vasopressin-induced 1 | 2.19988 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.19575 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 2.19033 |
| RWDD1 | RWD domain containing 1 | 2.17463 |
| IFT57 | intraflagellar transport 57 | 2.17417 |
| FBP1 | fructose-1,6-bisphosphatase 1 | 2.17241 |
| IGSF6 | immunoglobulin superfamily, member 6 | 2.17123 |
| VAMP8 | vesicle-associated membrane protein 8 | 2.14611 |
| FZD7 | frizzled class receptor 7 | 2.12696 |
| GPN3 | GPN-loop GTPase 3 | 2.12359 |
| TFEC | transcription factor EC | 2.11637 |
| GRN | granulin | 2.11419 |
| LXN | latexin | 2.11242 |
| IFI27 | interferon, alpha-inducible protein 27 | 2.08503 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | 2.07352 |
| ULBP2 | UL16 binding protein 2 | 2.06806 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | 2.06572 |
| ZFP36 | ZFP36 ring finger protein | 2.06055 |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | 2.05931 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 2.05709 |
| ARL3 | ADP-ribosylation factor-like 3 | 2.0492 |
| TAOK3 | TAO kinase 3 | 2.04323 |
| SLC25A44 | solute carrier family 25, member 44 | 2.04079 |
| RNF5 | ring finger protein 5, E3 ubiquitin protein ligase | 2.03872 |
| LSR | lipolysis stimulated lipoprotein receptor | 2.03731 |
| RMC1 | regulator of MON1-CCZ1 | 2.03022 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | 2.03016 |
| FAM117A | family with sequence similarity 117, member A | 2.0288 |
| ABHD6 | abhydrolase domain containing 6 | 2.02513 |
| CYP27B1 | cytochrome P450, family 27, subfamily B, polypeptide 1 | 2.02116 |
| COG2 | component of oligomeric golgi complex 2 | 2.02093 |
| DDIT4 | DNA-damage-inducible transcript 4 | 2.01589 |
| KATNIP | katanin interacting protein | 2.01563 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KEAP1 | kelch-like ECH-associated protein 1 | -8.19476 |
| CD320 | CD320 molecule | -7.81749 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -6.51109 |
| ISOC1 | isochorismatase domain containing 1 | -6.40951 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -5.58211 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | -5.5003 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -5.3658 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -5.31027 |
| TCERG1 | transcription elongation regulator 1 | -5.16145 |
| SPAG4 | sperm associated antigen 4 | -4.96163 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -4.75564 |
| SLC35F2 | solute carrier family 35, member F2 | -4.63111 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -4.53762 |
| TLCD3A | TLC domain containing 3A | -4.39587 |
| FOSL1 | FOS-like antigen 1 | -4.19713 |
| CCNB1 | cyclin B1 | -4.10172 |
| TRIB3 | tribbles pseudokinase 3 | -4.09743 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -3.96777 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -3.84468 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -3.83238 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.77066 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -3.70288 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -3.52556 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -3.50229 |
| FAT1 | FAT atypical cadherin 1 | -3.47737 |
| PUF60 | poly-U binding splicing factor 60KDa | -3.46699 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | -3.33237 |
| PGM1 | phosphoglucomutase 1 | -3.29016 |
| PCNA | proliferating cell nuclear antigen | -3.2851 |
| TEAD4 | TEA domain family member 4 | -3.24751 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -3.21877 |
| MTA1 | metastasis associated 1 | -3.20656 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -3.18415 |
| NUP85 | nucleoporin 85kDa | -3.15581 |
| SUMO4 | small ubiquitin-like modifier 4 | -3.09207 |
| ZNF586 | zinc finger protein 586 | -3.02157 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -2.90409 |
| MRPS7 | mitochondrial ribosomal protein S7 | -2.89136 |
| MAPK1IP1L | mitogen-activated protein kinase 1 interacting protein 1-like | -2.78544 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -2.77314 |
| DNM1L | dynamin 1-like | -2.73897 |
| PLK1 | polo-like kinase 1 | -2.71523 |
| SP3 | Sp3 transcription factor | -2.70665 |
| TMEM109 | transmembrane protein 109 | -2.67682 |
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | -2.66648 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -2.64424 |
| KCNE2 | potassium channel, voltage gated subfamily E regulatory beta subunit 2 | -2.64388 |
| MRPL58 | mitochondrial ribosomal protein L58 | -2.58088 |
| BIRC2 | baculoviral IAP repeat containing 2 | -2.57976 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | -2.57191 |
| IL4R | interleukin 4 receptor | -2.5641 |
| MYO19 | myosin XIX | -2.53632 |
| NUP62 | nucleoporin 62kDa | -2.52034 |
| TRAPPC3 | trafficking protein particle complex 3 | -2.50544 |
| NSMAF | neutral sphingomyelinase (N-SMase) activation associated factor | -2.46306 |
| YARS2 | tyrosyl-tRNA synthetase 2, mitochondrial | -2.45945 |
| GNAS | GNAS complex locus | -2.4491 |
| SINHCAF | SIN3-HDAC complex associated factor | -2.42923 |
| CMAS | cytidine monophosphate N-acetylneuraminic acid synthetase | -2.4289 |
| STAMBP | STAM binding protein | -2.42709 |
| NUP153 | nucleoporin 153kDa | -2.40742 |
| TRIM13 | tripartite motif containing 13 | -2.37191 |
| SNRPA | small nuclear ribonucleoprotein polypeptide A | -2.34406 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | -2.32032 |
| RAB11FIP2 | RAB11 family interacting protein 2 (class I) | -2.28995 |
| CASC3 | cancer susceptibility candidate 3 | -2.28798 |
| RAP1GAP | RAP1 GTPase activating protein | -2.26998 |
| MRPS2 | mitochondrial ribosomal protein S2 | -2.26617 |
| CTCF | CCCTC-binding factor (zinc finger protein) | -2.25112 |
| RRAGA | Ras-related GTP binding A | -2.24727 |
| TMED1 | transmembrane emp24 protein transport domain containing 1 | -2.2294 |
| MAP3K4 | mitogen-activated protein kinase kinase kinase 4 | -2.22211 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -2.19322 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -2.19253 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -2.19232 |
| MRM3 | mitochondrial rRNA methyltransferase 3 | -2.19183 |
| SRSF4 | serine/arginine-rich splicing factor 4 | -2.1911 |
| ANAPC1 | anaphase promoting complex subunit 1 | -2.18065 |
| PPCS | phosphopantothenoylcysteine synthetase | -2.17908 |
| YTHDF2 | YTH N(6)-methyladenosine RNA binding protein 2 | -2.17668 |
| FOXJ2 | forkhead box J2 | -2.15676 |
| RESF1 | retroelement silencing factor 1 | -2.15524 |
| ALG8 | ALG8, alpha-1,3-glucosyltransferase | -2.15008 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.14622 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -2.14463 |
| CPNE2 | copine II | -2.12491 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -2.12383 |
| PROS1 | protein S (alpha) | -2.11914 |
| PEF1 | penta-EF-hand domain containing 1 | -2.1156 |
| DCAF16 | DDB1 and CUL4 associated factor 16 | -2.11048 |
| NID1 | nidogen 1 | -2.10878 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -2.10719 |
| ANKRD10 | ankyrin repeat domain 10 | -2.10707 |
| MRPS18B | mitochondrial ribosomal protein S18B | -2.10095 |
| ASGR1 | asialoglycoprotein receptor 1 | -2.08757 |
| RELN | reelin | -2.08734 |
| GPHN | gephyrin | -2.07805 |
| CLASRP | CLK4-associating serine/arginine rich protein | -2.07276 |
| ASGR2 | asialoglycoprotein receptor 2 | -2.07206 |
| TMEM39B | transmembrane protein 39B | -2.07171 |
| NOL11 | nucleolar protein 11 | -2.06666 |
| TRAP1 | TNF receptor-associated protein 1 | -2.05901 |
| MAPK6 | mitogen-activated protein kinase 6 | -2.05616 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -2.0493 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -2.04664 |
| CCNA2 | cyclin A2 | -2.04382 |
| FAM193A | family with sequence similarity 193, member A | -2.03745 |
| MBNL3 | muscleblind-like splicing regulator 3 | -2.03434 |
| PPP1R17 | protein phosphatase 1, regulatory subunit 17 | -2.0335 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | -2.02964 |
| NEK3 | NIMA-related kinase 3 | -2.02393 |
| CCKBR | cholecystokinin B receptor | -2.02344 |
| FGFR4 | fibroblast growth factor receptor 4 | -2.01974 |
| EGF | epidermal growth factor | -2.01805 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | -2.00917 |
| KLHL9 | kelch-like family member 9 | -2.00189 |
| AMPH | amphiphysin | -2.0009 |
