CRCGN014_HEPG2_3H:M24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

55 genes differentially expressed following the CRCGN014_HEPG2_3H:M24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.46514
NOTCH1 notch 1 4.12196
GSTZ1 glutathione S-transferase zeta 1 3.52619
CNPY3 canopy FGF signaling regulator 3 3.34814
TWF2 twinfilin actin binding protein 2 3.24119
MAP7 microtubule-associated protein 7 3.08739
CHN1 chimerin 1 2.91039
KIF14 kinesin family member 14 2.87406
SKIC8 SKI8 subunit of superkiller complex 2.54722
GPER1 G protein-coupled estrogen receptor 1 2.5343
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.53291
GPATCH8 G patch domain containing 8 2.40064
TM9SF3 transmembrane 9 superfamily member 3 2.25475
CHEK2 checkpoint kinase 2 2.11072
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.10401
DSG2 desmoglein 2 2.09402
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2.06622

decreased expression

Symbol Name Standardized Value
FGFR4 fibroblast growth factor receptor 4 -8.27785
TLCD3A TLC domain containing 3A -6.18779
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.16274
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -5.10169
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.05163
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.85188
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.7557
CHMP4B charged multivesicular body protein 4B -4.39635
GNAS GNAS complex locus -3.49817
OXA1L oxidase (cytochrome c) assembly 1-like -3.046
TBC1D31 TBC1 domain family, member 31 -2.73597
HMOX1 heme oxygenase 1 -2.71059
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.55378
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.46749
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -2.45767
RRH retinal pigment epithelium-derived rhodopsin homolog -2.41043
PMM2 phosphomannomutase 2 -2.34177
PSG2 pregnancy specific beta-1-glycoprotein 2 -2.31449
UNC5C unc-5 homolog C (C. elegans) -2.29104
PRPF4 pre-mRNA processing factor 4 -2.22084
SBDS Shwachman-Bodian-Diamond syndrome -2.20526
TRPC7 transient receptor potential cation channel, subfamily C, member 7 -2.19659
CSK c-src tyrosine kinase -2.18903
UBE3C ubiquitin protein ligase E3C -2.18751
USP27X ubiquitin specific peptidase 27, X-linked -2.12156
KITLG KIT ligand -2.12121
GJA9 gap junction protein, alpha 9, 59kDa -2.10749
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -2.09562
IL37 interleukin 37 -2.08346
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) -2.06991
TCP11 t-complex 11, testis-specific -2.06801
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa -2.05639
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 -2.04418
BRDT bromodomain, testis-specific -2.03927
COLEC10 collectin sub-family member 10 (C-type lectin) -2.01634
OTOR otoraplin -2.00984
ARSL arylsulfatase L -2.00301
PRDM9 PR domain containing 9 -2.00167