| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | disodium 4-amino-3-((e)-{4'-[(e)-(2,4-diaminophenyl)diazenyl][1,1'-biphenyl]-4-yl}diazenyl)-5-hydroxy-6-[(e)-phenyldiazenyl]-2,7-naphthalenedisulfonate 20.47 um perturbation at 3 h in HEPG2 (Carcinogenome) |
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63 genes differentially expressed following the CRCGN014_HEPG2_3H:N01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 9.5687 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 5.32105 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 5.20147 |
| PMM2 | phosphomannomutase 2 | 4.93165 |
| CHMP6 | charged multivesicular body protein 6 | 4.69018 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 4.48666 |
| NOSIP | nitric oxide synthase interacting protein | 4.23244 |
| SKIC8 | SKI8 subunit of superkiller complex | 3.95146 |
| MAP7 | microtubule-associated protein 7 | 3.79564 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 3.57565 |
| CHN1 | chimerin 1 | 3.33599 |
| HEBP1 | heme binding protein 1 | 3.33358 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | 3.25961 |
| SHB | Src homology 2 domain containing adaptor protein B | 3.21991 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.96276 |
| H2BC12 | H2B clustered histone 12 | 2.94468 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | 2.92652 |
| DHDDS | dehydrodolichyl diphosphate synthase | 2.80318 |
| UBR7 | ubiquitin protein ligase E3 component n-recognin 7 (putative) | 2.76014 |
| TRIM13 | tripartite motif containing 13 | 2.7339 |
| DIPK1A | divergent protein kinase domain 1A | 2.65786 |
| CCNA1 | cyclin A1 | 2.41195 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 2.3364 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 2.28483 |
| CCNC | cyclin C | 2.2489 |
| SFTPB | surfactant protein B | 2.24165 |
| ITGA7 | integrin, alpha 7 | 2.17601 |
| SLC19A3 | solute carrier family 19 (thiamine transporter), member 3 | 2.13275 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.0879 |
| PCDHB12 | protocadherin beta 12 | 2.08789 |
| RAB21 | RAB21, member RAS oncogene family | 2.07809 |
| RAB31 | RAB31, member RAS oncogene family | 2.03808 |
| EPHA4 | EPH receptor A4 | 2.03063 |
| DHX32 | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | 2.01166 |
| SCGB1D1 | secretoglobin, family 1D, member 1 | 2.00974 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCNB2 | cyclin B2 | -8.57198 |
| FGFR4 | fibroblast growth factor receptor 4 | -7.91249 |
| LDHD | lactate dehydrogenase D | -4.62047 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.60992 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -4.55563 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -4.51821 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -4.44161 |
| SLC35F2 | solute carrier family 35, member F2 | -3.59459 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.46196 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -3.34141 |
| RGS2 | regulator of G-protein signaling 2 | -3.21752 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | -3.16284 |
| TWF2 | twinfilin actin binding protein 2 | -2.86145 |
| CSK | c-src tyrosine kinase | -2.78914 |
| RHOC | ras homolog family member C | -2.66103 |
| TBC1D31 | TBC1 domain family, member 31 | -2.65163 |
| WASHC4 | WASH complex subunit 4 | -2.39943 |
| CCDC90B | coiled-coil domain containing 90B | -2.24657 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -2.23811 |
| PRSS23 | protease, serine, 23 | -2.22911 |
| CCNH | cyclin H | -2.18538 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | -2.17947 |
| CHEK1 | checkpoint kinase 1 | -2.14476 |
| SPG11 | spastic paraplegia 11 (autosomal recessive) | -2.11974 |
| PRPF4 | pre-mRNA processing factor 4 | -2.09487 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -2.0632 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | -2.04576 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -2.04059 |
